Search results: Sage Journals

Free accessResearch articleFirst published December, 2023

Evaluation of the Carcinogenic Potential of Enarodustat (JTZ-951),a Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor,in 26-Week Tg.rasH2 Mouse Study and 2-Year Sprague-Dawley Rat Study

Yusuke Kemmochi, Kaoru Toyoda, Tomio Ishida [...]

International Journal of Toxicology

Free accessResearch articleFirst published May, 2020

Tg.rasH2 Mouse Model for Assessing Carcinogenic Potential of Pharmaceuticals: Industry Survey of Current Practices

Matthew S. Bogdanffy, Jacob Lesniak, Raja Mangipudy [...]

International Journal of Toxicology

Free accessResearch articleFirst published January, 2019

Comparison of the Class Effects of Antisense Oligonucleotides in CByB6F1-Tg(HRAS)2Jic and CD-1 Mice

Tae-Won Kim, Chris N. Papagiannis, Laura S. Zwick [...]

Toxicologic Pathology

Free accessResearch articleFirst published January, 2013

Historical Control Data of Spontaneous Tumors in Transgenic CByB6F1-Tg(HRAS)2Jic (Tg.rasH2) Mice

Madhav G. Paranjpe, Reem H. Elbekaei, Sudhir A. Shah [...]

International Journal of Toxicology

Free accessArticle commentaryFirst published July, 2017

Tg.rasH2 Mice and not CByB6F1 Mice Should Be Used for 28-Day Dose Range Finding Studies Prior to 26-Week Tg.rasH2 Carcinogenicity Studies

Madhav G. Paranjpe, Jessica Belich, Tom J. Vidmar [...]

International Journal of Toxicology

Free accessResearch articleFirst published October, 2014

The 26-Week Tg.Rash2 Mice Carcinogenicity Studies

Madhav G. Paranjpe, Melissa D. Denton, Reem H. Elbekai

Toxicologic Pathology

Restricted accessResearch articleFirst published February, 2026

Incidence of Spontaneous and Urethane-Induced Tumors in a 26-Week Carcinogenicity Study in Tg.rasH2 Mice Sourced From CLEA,Japan

Madhav Paranjpe, Amod Kale, Narendra Deshmukh [...]

International Journal of Toxicology

Free accessResearch articleFirst published December, 2013

Incidence of Spontaneous Non-Neoplastic Lesions in Transgenic CBYB6F1-Tg(HRAS)2Jic Mice

Madhav G. Paranjpe, Sudhir A. Shah, Melissa D. Denton [...]

Toxicologic Pathology

Free accessArticle commentaryFirst published May, 2021

Proposal to Eliminate Urethane-Treated Positive Control Dose Groups in 26-Week Tg.rasH2 Carcinogenicity Studies

Madhav G. Paranjpe, Daniel Rudmann, Aaron Sargeant [...]

International Journal of Toxicology

Free accessResearch articleFirst published July, 2016

Renal Tumors in 26-Week Tg.Rash2 Mice Carcinogenicity Studies

Madhav G. Paranjpe, Jessica L. Belich, Marie E. McKeon [...]

Toxicologic Pathology

Free accessResearch articleFirst published December, 2023

Evaluation of the Carcinogenic Potential of Enarodustat (JTZ-951),a Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor,in 26-Week Tg.rasH2 Mouse Study and 2-Year Sprague-Dawley Rat Study

Yusuke Kemmochi, Kaoru Toyoda, Tomio Ishida [...]

International Journal of Toxicology

Free accessResearch articleFirst published May, 2020

Tg.rasH2 Mouse Model for Assessing Carcinogenic Potential of Pharmaceuticals: Industry Survey of Current Practices

Matthew S. Bogdanffy, Jacob Lesniak, Raja Mangipudy [...]

International Journal of Toxicology

Free accessResearch articleFirst published January, 2019

Comparison of the Class Effects of Antisense Oligonucleotides in CByB6F1-Tg(HRAS)2Jic and CD-1 Mice

Tae-Won Kim, Chris N. Papagiannis, Laura S. Zwick [...]

Toxicologic Pathology

Free accessResearch articleFirst published January, 2013

Historical Control Data of Spontaneous Tumors in Transgenic CByB6F1-Tg(HRAS)2Jic (Tg.rasH2) Mice

Madhav G. Paranjpe, Reem H. Elbekaei, Sudhir A. Shah [...]

International Journal of Toxicology

Free accessArticle commentaryFirst published July, 2017

Tg.rasH2 Mice and not CByB6F1 Mice Should Be Used for 28-Day Dose Range Finding Studies Prior to 26-Week Tg.rasH2 Carcinogenicity Studies

Madhav G. Paranjpe, Jessica Belich, Tom J. Vidmar [...]

International Journal of Toxicology

Free accessResearch articleFirst published October, 2014

The 26-Week Tg.Rash2 Mice Carcinogenicity Studies

Madhav G. Paranjpe, Melissa D. Denton, Reem H. Elbekai

Toxicologic Pathology

Restricted accessResearch articleFirst published February, 2026

Incidence of Spontaneous and Urethane-Induced Tumors in a 26-Week Carcinogenicity Study in Tg.rasH2 Mice Sourced From CLEA,Japan

Madhav Paranjpe, Amod Kale, Narendra Deshmukh [...]

International Journal of Toxicology

Free accessResearch articleFirst published December, 2013

Incidence of Spontaneous Non-Neoplastic Lesions in Transgenic CBYB6F1-Tg(HRAS)2Jic Mice

Madhav G. Paranjpe, Sudhir A. Shah, Melissa D. Denton [...]

Toxicologic Pathology

Free accessArticle commentaryFirst published May, 2021

Proposal to Eliminate Urethane-Treated Positive Control Dose Groups in 26-Week Tg.rasH2 Carcinogenicity Studies

Madhav G. Paranjpe, Daniel Rudmann, Aaron Sargeant [...]

International Journal of Toxicology

Free accessResearch articleFirst published July, 2016

Renal Tumors in 26-Week Tg.Rash2 Mice Carcinogenicity Studies

Madhav G. Paranjpe, Jessica L. Belich, Marie E. McKeon [...]

Toxicologic Pathology