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Research article

First published 2023-12

Evaluation of the Carcinogenic Potential of Enarodustat (JTZ-951),a Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor,in 26-Week Tg.rasH2 Mouse Study and 2-Year Sprague-Dawley Rat Study

Yusuke Kemmochi, Kaoru Toyoda, Tomio Ishida [...]

International Journal of Toxicology

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Research article

First published 2020-5

Tg.rasH2 Mouse Model for Assessing Carcinogenic Potential of Pharmaceuticals: Industry Survey of Current Practices

Matthew S. Bogdanffy, Jacob Lesniak, Raja Mangipudy [...]

International Journal of Toxicology

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Research article

First published 2019-1

Comparison of the Class Effects of Antisense Oligonucleotides in CByB6F1-Tg(HRAS)2Jic and CD-1 Mice

Tae-Won Kim, Chris N. Papagiannis, Laura S. Zwick [...]

Toxicologic Pathology

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Research article

First published 2013-1

Historical Control Data of Spontaneous Tumors in Transgenic CByB6F1-Tg(HRAS)2Jic (Tg.rasH2) Mice

Madhav G. Paranjpe, Reem H. Elbekaei, Sudhir A. Shah [...]

International Journal of Toxicology

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Research article

First published 2026-2

Incidence of Spontaneous and Urethane-Induced Tumors in a 26-Week Carcinogenicity Study in Tg.rasH2 Mice Sourced From CLEA,Japan

Madhav Paranjpe, Amod Kale, Narendra Deshmukh [...]

International Journal of Toxicology

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Article commentary

First published 2017-7

Tg.rasH2 Mice and not CByB6F1 Mice Should Be Used for 28-Day Dose Range Finding Studies Prior to 26-Week Tg.rasH2 Carcinogenicity Studies

Madhav G. Paranjpe, Jessica Belich, Tom J. Vidmar [...]

International Journal of Toxicology

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Research article

First published 2014-10

The 26-Week Tg.Rash2 Mice Carcinogenicity Studies

Madhav G. Paranjpe, Melissa D. Denton, Reem H. Elbekai

Toxicologic Pathology

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Research article

First published 2013-12

Incidence of Spontaneous Non-Neoplastic Lesions in Transgenic CBYB6F1-Tg(HRAS)2Jic Mice

Madhav G. Paranjpe, Sudhir A. Shah, Melissa D. Denton [...]

Toxicologic Pathology

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Article commentary

First published 2021-5

Proposal to Eliminate Urethane-Treated Positive Control Dose Groups in 26-Week Tg.rasH2 Carcinogenicity Studies

Madhav G. Paranjpe, Daniel Rudmann, Aaron Sargeant [...]

International Journal of Toxicology

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Research article

First published 2016-7

Renal Tumors in 26-Week Tg.Rash2 Mice Carcinogenicity Studies

Madhav G. Paranjpe, Jessica L. Belich, Marie E. McKeon [...]

Toxicologic Pathology

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