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Research article

First published 2022-5

Distortion Product Otoacoustic Emission Test is Not the Test to Use in Nonclinical Safety Assessment

David V Gauvin, Margaret McComb, Rachel Tapp [...]

International Journal of Toxicology

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Research article

First published 2021

Nonclinical abuse liability testing of new CNS-active drugs: Role of sex as a critical factor for drug scheduling

David V Gauvin, Zachary J Zimmermann, Mary Jeanne Kallman

Drug Science,Policy and Law

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Research article

First published 1994-12

Regulatory Considerations for Oligonucleotide Drugs: Updated Recommendations for Pharmacology and Toxicology Studies

Lauren E. Black, James G. Farrelly, Joy A. Cavagnaro [...]

Nucleic Acid Therapeutics

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Research article

First published 2025-10

Evaluation of Biomarkers to Detect Early Prothrombotic Imbalance in Rat Models of Hypercoagulability Induced by Thromboplastin Infusion and Hypofibrinolysis Induced by Tranexamic Acid

Marjory B. Brooks, Cindy E. Fishman, Mohanapriya Kamalakannan [...]

Toxicologic Pathology

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Research article

First published 2022-6

A Technical Guide to Sampling the Beagle Dog Nervous System for General Toxicity and Neurotoxicity Studies

Xavier Palazzi, Ingrid D. Pardo, Hayley Ritenour [...]

Toxicologic Pathology

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Research article

First published 2024-12

The Role of Neuropathology Evaluation in the Nonclinical Assessment of Seizure Liability

Katie Sokolowski, Judy Liu, Marcus S. Delatte [...]

Toxicologic Pathology

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Research article

First published 2021-10

Nonclinical Safety Profile of Sotorasib,a KRAS G12C -Specific Covalent Inhibitor for the Treatment of KRAS p.G12C -Mutated Cancer

Katsu Ishida, Jonathan A. Werner, Rhian Davies [...]

International Journal of Toxicology

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Research article

First published 2012-6

Myocardial Mononuclear Cell Infiltrates Are Not Associated with Increased Serum Cardiac Troponin I in Cynomolgus Monkeys

Michael E. Dunn, Denise Coluccio, Tanja S. Zabka [...]

Toxicologic Pathology

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Research article

First published 2013-9

Nonclinical Toxicology Assessments Support the Chronic Safety of Dapagliflozin,a First-in-Class Sodium-Glucose Cotransporter 2 Inhibitor

Mark Tirmenstein, Thomas E. Dorr, Evan B. Janovitz [...]

International Journal of Toxicology

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Research article

First published 2020-10

Nervous System Sampling for General Toxicity and Neurotoxicity Studies in Rabbits

Ingrid D. Pardo, Deepa B. Rao, James P. Morrison [...]

Toxicologic Pathology

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