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Research article

First published 2017-11

Standard Curves Are Necessary to Determine Pharmacological Properties for Ligands in Functional Assays Using Competition Binding Technologies

Neil T. Burford, John Watson, Andrew Alt

ASSAY and Drug Development Technologies

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Review article

First published 2021-8

The Problems of Applying Classical Pharmacology Analysis to Modern In Vitro Drug Discovery Assays: Slow Binding Kinetics and High Target Concentration

Sam R. J. Hoare

Journal of Biomolecular Screening

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Research article

First published 2008-06

A Robust and High-Capacity [ 35 S]GTP γ S Binding Assay for Determining Antagonist and Inverse Agonist Pharmacological Parameters of Histamine H 3 Receptor Ligands

Thomas R. Miller, John L. Baranowski, Brian R. Estvander [...]

ASSAY and Drug Development Technologies

Free access

Research article

First published 2018-1

A High-Throughput Dose-Response Cellular Thermal Shift Assay for Rapid Screening of Drug Target Engagement in Living Cells,Exemplified Using SMYD3 and IDO1

Dean E. McNulty, William G. Bonnette, Hongwei Qi [...]

Journal of Biomolecular Screening

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Research article

First published 2021-4

Target Validation Using PROTACs: Applying the Four Pillars Framework

Radosław P. Nowak, Lyn H. Jones

Journal of Biomolecular Screening

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Research article

First published 2021-9

Bioelectronic Measurement of Target Engagement to a Membrane-Bound Transporter

William E. Martinez, Jaime E. Arenas, Leo Mok [...]

Journal of Biomolecular Screening

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Research article

First published 2019-10

SLC6A14,a Pivotal Actor on Cancer Stage: When Function Meets Structure

Luca Palazzolo, Chiara Paravicini, Tommaso Laurenzi [...]

Journal of Biomolecular Screening

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Research article

First published 2014-6

Combined Analysis of Phenotypic and Target-Based Screening in Assay Networks

S. Joshua Swamidass, Constantino N. Schillebeeckx, Matthew Matlock [...]

Journal of Biomolecular Screening

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Research article

First published 2013-12

The Contribution of Mechanistic Understanding to Phenotypic Screening for First-in-Class Medicines

David C. Swinney

Journal of Biomolecular Screening

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Research article

First published 2012-2

TR-FRET-Based High-Throughput Screening Assay for Identification of UBC13 Inhibitors

Charitha Madiraju, Kate Welsh, Michael P. Cuddy [...]

Journal of Biomolecular Screening

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