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Research article

First published 2006-02

State-Dependent Compound Inhibition of Na v 1.2 Sodium Channels Using the FLIPR V m Dye: On-Target and Off-Target Effects of Diverse Pharmacological Agents

Elfrida R. Benjamin, Farhana Pruthi, Shakira Olanrewaju [...]

Journal of Biomolecular Screening

Retricted access

Research article

First published 2009-11

The Use of Computer Models in Pharmaceutical Safety Evaluation

Scott Boyer

Alternatives to Laboratory Animals

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Research article

First published 2013-2

On-target and Off-target-based Toxicologic Effects

Daniel G. Rudmann

Toxicologic Pathology

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Research article

First published 2013-9

Nonclinical Toxicology Assessments Support the Chronic Safety of Dapagliflozin,a First-in-Class Sodium-Glucose Cotransporter 2 Inhibitor

Mark Tirmenstein, Thomas E. Dorr, Evan B. Janovitz [...]

International Journal of Toxicology

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Research article

First published 2022-5

Investigational New Drug Enabling Nonclinical Safety Pharmacology Assessment of the Iminosugar UV-4,a Broad-Spectrum Host-Targeted Antiviral Agent

Jeffry Shearer, Gary Wolfe, Aruna Sampath [...]

International Journal of Toxicology

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Research article

First published 2013-11

Phenotypic Screening of the Prestwick Library for Treatment of Parkinson's Tremor Symptoms using a Humanized Quantitative Systems Pharmacology Platform

Athan Spiros, Patrick Roberts, Hugo Geerts

Journal of Parkinson’s Disease

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Research article

First published 2012-8

Off-Target Platelet Activation in Macaques Unique to a Therapeutic Monoclonal Antibody

Michael J. Santostefano, Jacqueline Kirchner, Christine Vissinga [...]

Toxicologic Pathology

Retricted access

Review article

First published 2023-03

The Promises of Proteomics and Metabolomics for Unravelling the Mechanism and Side Effect Landscape of Beta-Adrenoceptor Antagonists in Cardiovascular Therapeutics

Shreyayukta Chakraborty, Arpita Kannihalli, Abhishek Mohanty [...]

OMICS: A Journal of Integrative Biology

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Research article

First published 2021-10

Nonclinical Safety Profile of Sotorasib,a KRAS G12C -Specific Covalent Inhibitor for the Treatment of KRAS p.G12C -Mutated Cancer

Katsu Ishida, Jonathan A. Werner, Rhian Davies [...]

International Journal of Toxicology

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Research article

First published 2017-1

Translational Safety Genetics

Priyasma Bhoumik, Alberto Del Rio-Espinola, Florian Hahne [...]

Toxicologic Pathology

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