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Research article

First published 2020-8

A Mechanistic High-Content Analysis Assay Using a Chimeric Androgen Receptor That Rapidly Characterizes Androgenic Chemicals

Adam T. Szafran, Michael J. Bolt, Caroline E. Obkirchner [...]

Journal of Biomolecular Screening

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Research article

First published 2007-02

Three Mechanistically Distinct Kinase Assays Compared: Measurement of Intrinsic ATPase Activity Identified the Most Comprehensive Set of ITK Inhibitors

Mohammed A. Kashem, Richard M. Nelson, Jeffrey D. Yingling [...]

Journal of Biomolecular Screening

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Research article

First published 2009-08

A Mechanistically Relevant Cytotoxicity Assay Based on the Detection of Cellular GFP

Michael Halter, Jamie L. Almeida, Alessandro Tona [...]

ASSAY and Drug Development Technologies

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Research article

First published 2015-11

Mixture Effects of 3 Mechanistically Different Steroidogenic Disruptors (Prochloraz,Genistein,and Ketoconazole) in the H295R Cell Assay

Frederik Knud Nielsen, Cecilie Hurup Hansen, Jennifer Anna Fey [...]

International Journal of Toxicology

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Research article

First published 1987-1

Strategies for Biological Testing of Biomaterials

Sharon J. Northup

Journal of Biomaterials Applications

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Research article

First published 2002-01

Evaluation of the Tg.AC Transgenic Mouse Assay for Testing the Human Carcinogenic Potential of Pharmaceuticals—Practical Pointers,Mechanistic Clues,and New Questions

Frank D. Sistare, Karol L. Thompson, Ronald Honchel [...]

International Journal of Toxicology

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Research article

First published 2011-12

Validation of a Patch Clamp Screening Protocol That Simultaneously Measures Compound Activity in Multiple States of the Voltage-Gated Sodium Channel Nav1.2

Yi Liu, Edward J. Beck, Christopher M. Flores

ASSAY and Drug Development Technologies

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Research article

First published 2020-1

Development of a Bioluminescent High-Throughput Screening Assay for Nicotinamide Mononucleotide Adenylyltransferase (NMNAT)

Brad A. Haubrich, Chakk Ramesha, David C. Swinney

Journal of Biomolecular Screening

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Research article

First published 2013-12

The Contribution of Mechanistic Understanding to Phenotypic Screening for First-in-Class Medicines

David C. Swinney

Journal of Biomolecular Screening

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Research article

First published 2012-1

Configuration of a High-Content Imaging Platform for Hit Identification and Pharmacological Assessment of JMJD3 Demethylase Enzyme Inhibitors

Alpa Mulji, Carl Haslam, Fiona Brown [...]

Journal of Biomolecular Screening

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