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Abstract

Study design

Prospective, observational.

Objectives

The aim of our study was to assess the amount of reduction in lean muscle mass (LMM) of multifidus muscle (MFM) between conventional open Transforaminal lumbar interbody fusion (CO-TLIF) as compared to Minimally invasive spine Transforaminal lumbar interbody fusion (MIS-TLIF).

Methods

This study was conducted between 2017 and 2020. It included 100 patients divided into two groups, 50 patients treated with CO-TLIF, 50 treated with MIS-TLIF. Only patients undergoing single level, primary lumbar fusion at L4-5 or L5-S1 level for degenerative pathologies were included. All patients were assessed by magnetic resonance imaging (MRI) scans 1-year post surgery. Measurements were performed using ImageJ image processing program.

Results

Mean percentage reduction in LMM in CO-TLIF group was 45.52 ± 12.36% and MIS-TLIF group was 25.83 ± 9.64% [statistically significant (t = 8.78, P < .001)]. Mean percentage reduction in LMM on side of cage insertion was 39.63 ± 15.96% and opposite side was 31.40 ± 15.01% [statistically significant (t = 9.06, P < .001)]. Mean reduction of LMM among males was 29.38 ± 15.23% and females was 40.42 ± 12.67% [statistically significant (t = −3.95, P < .001)].

We observed significant but weak degree of correlation between age and percentage reduction of LMM (r = .22, P = .028).

Conclusion

Mean reduction in LMM was greater in CO-TLIF group as compared to MIS-TLIF. There was greater reduction in LMM in females and on side of cage insertion. We also found greater reduction in LMM with increasing age in both groups.

Keywords

transforaminal lumbar interbody fusion fibrosis multifidus lean muscle mass

Clinical trial registry number: CTRI/2017/08/009540.

Introduction

In 1940, the first reported posterior lumbar interbody fusion (PLIF) was performed using spinous process autograft.¹ Transforaminal lumbar interbody fusion (TLIF) was popularized by Harms et al. as an alternative to PLIF.² Transforaminal lumbar interbody fusion offers several technical advantages over PLIF. One major advantage is reduced retraction of dural sac lessening risk of postoperative radiculitis.^2,3 For decades, open approaches have been considered the gold standard when instrumented fusion is used, with reliable improvement in patient’s quality of life. However, open approaches are associated with significant soft-tissue morbidity.⁴ Minimally invasive spine surgery (MIS) has attracted increasing attention in the past few years.⁴ The first description of MIS-TLIF appeared in the literature in 2003, and since that time, use of this technique has been gaining popularity.⁵ Proponents of MIS fusion suggest that it is associated with reduced blood loss, short hospital stay and lesser postoperative pain. Also, it reduces soft-tissue dissection and maintains structural integrity of paraspinal musculature.⁶

Intramuscular pressure has been seen to increase substantially in conventional open posterior spine surgery with use of self retaining retractors. Up to 36.80% of multifidus muscle (MFM) atrophy was seen in patients undergoing conventional open TLIF (CO-TLIF).⁷ The denervation and subsequent atrophy of paraspinal muscles, particularly the MFM, leads to disability and increased biomechanical strain. Also, fibrosis can compress neural tissue causing postoperative radiculopathy.⁸ This injury to MFM leads to reduction in the lean muscle mass (LMM) which can be assessed on magnetic resonance imaging (MRI) in the post-operative period.^8,9 The aim of our study was to assess the amount of reduction in LMM of MFM at the operated level in CO-TLIF as compared to MIS-TLIF. We believe, this quantitative reduction in the LMM of MFM would give an idea about the probable disability the patients will experience in their post-operative period.

Methods

This single center, prospective observational study was conducted at a tertiary care spine institute in India. The study duration was from August 2017 to July 2020. Approval from the Institutional Ethics committee of Stavya Spine Hospital and Research Institution (Number-SSHRI/ CS/ NS/ Fibro/ DD/ 18/ 052016) and CTRI registration was done prior to commencement. This study was a prospective study of 100 operated patients of TLIF, 50 being MIS-TLIF and 50 being CO-TLIF. Only patients who underwent single level, primary lumbar fusion at L4-5 or L5-S1 level for degenerative pathologies were included. Informed consent was taken from those patients who were willing to participate in study for use of clinical data including images. The enrolled study subjects were followed up for 1 year postoperatively. Patients undergoing revision lumbar surgery, decompression only procedures, multi-level fusion surgeries, underlying diagnosis other than degenerative pathologies (infection/ tumor, etc.), prior history of radiation were excluded from the study.

All surgical procedures had been performed by the same team of surgeons. All patients were assessed by MRI scans performed 1-year post surgery (Model: 1.5 T, Multiva, Phillips Equip ID: 68003991) by the same radiologist with > 10 years’ experience in the field of musculoskeletal imaging. Few of the preoperative MRI scans were performed at our center and the rest being scans from outside. Though this is a potential limitation, all scans were 1.5 T and were assessed by the same image processing program, which makes them fairly uniform. Image of Axial T2W MRI was taken at the Vertebral End Plate Level superior and adjacent to the level of TLIF. For example, for TLIF at the L4-L5 level, Axial T2W image at L4 lower end plate level was taken (Figure 1). Both preoperative and postoperative images were taken at the same level. To avoid disparity in measurement scales due to different sizes of images and not having calibrated MRI scans, we used a ratio for calculating the fibrosis where in the total area of bilateral MFM was divided by area of the vertebral body (Figure 2). This was the reason behind taking the image at lower end plate level of L4 as an accurate denominator of the vertebral body area cannot be taken at the disc level. Also, the metal artifact at end plate level is lesser than the disc level in the postoperative MRI. Thus, we got 2 values of MFM area through which we calculated the loss of LMM between the 2 groups. We also calculated the MFM area within the groups, for the side through which the cage was inserted and compared that with the opposite side in the MIS-TLIF group. All measurements were independently performed by 2 orthopedic spine surgeons and reviewed by the same radiologist who performed the MRI scan using ImageJ image^10,11 processing program and a consensus value was reached for every measurement. In case of any conflict, the mean value was taken.

Figure 1.

Image of Axial T2W MRI at Vertebral End Plate Level superior adjacent to the level of TLIF (e.g., For TLIF of L4-L5: Axial T2W image at L4 lower end plate level) is taken. Both preoperative and postoperative images were taken at the same level. A- Axial section at vertebral end plate level, B- Axial section at disc level.

Figure 2.

To avoid disparity in measurement scales due to different sizes of images and not having a scale mentioned in the MRI we have selected the ratio as follows- Total area of bilateral multifidus/ Area of vertebral body (B+C/A).

Statistical analysis: SPSS software version 23 (IBM SPSS, IBM Corp, 2017)¹² was used for statistical analysis. The data was represented in terms of mean and standard deviation. Difference between 2 groups of continuous variables was assessed using t-test.¹³ A P value of less than .05 was considered statistically significant. Pearson correlation coefficient¹⁴ was used to see association between 2 continuous variables and data was represented as a scatter plot.

Results

We had a total of 100 patients in our series. There were 43 males and 57 female patients. The mean age of patients was 49.06 ± 11.61 (Range 20-82) years. The mean age in CO-TLIF group was 50.74 ± 10.48 years. The mean age in MIS-TLIF group was 47.38 ± 12.52 years. The most commonly operated surgical level was L5-S1 level in CO-TLIF group and L4-5 level in the MIS-TLIF group. The mean percentage reduction in LMM in the CO-TLIF group was 45.52 ± 12.36%. The mean percentage reduction in LMM in the MIS-TLIF group was 25.83 ± 9.64%. On applying, the independent t-test, the difference in mean reduction of LMM was statistically significant (t = 8.78, P < .001) (Figure 3). The mean percentage reduction in LMM on side of cage insertion in was 39.63 ± 15.96% and on the opposite side was 31.40 ± 15.01% (Figure 4). On applying the paired t-test, the difference was found to be statistically significant (t = 9.06, P < .001). We also observed a significant but weak degree of correlation between age and percentage reduction of the LMM (r = .22, P = .028). Increasing age was associated with greater percentage reduction in LMM with r value of .22 (Figure 5). The mean reduction of LMM among males was 29.38 ± 15.23% and females was 40.42 ± 12.67%. On applying, independent t-test, the difference in mean LMM among both sexes was statistically significant (t = −3.95, P < .001) (Figure 6).

Figure 3.

The mean percentage reduction in LMM in the CO-TLIF group was 45.52 ± 12.36 and the MIS-TLIF group was 25.83 ± 9.64 %. On applying, the independent t-test, the difference in mean reduction of LMM was statistically significant. Representative images showing greater postoperative MFM fibrosis in CO-TLIF (B) as compared to MIS-TLIF (A).

Figure 4.

The mean reduction in LMM on side of cage insertion was greater than the opposite side as seen in the representative figure above where cage is inserted from left with greater MFM atrophy on left side.

Figure 5.

We observed significant but weak degree of correlation between age and LMR% (r = .22, P = .028). Increasing age was associated with greater percentage reduction in LMM.

Figure 6.

Schematic diagram showing the location of the MFM (A) and its innervation by the medial branch of dorsal ramus (B), with no inter-segmental nerve supply as in the other paraspinal muscles [Longissimus (L) iliocostal muscles (IC) multifidus muscle (M) rotators lumborum muscles (RL) posterior thoraco-lumbar fascia (PTLF) psoas muscle (P) quadratus lumborum muscle (QL)].

Discussion

Minimally invasive spine was developed to reduce the degree of iatrogenic muscle injury while still accomplishing the goals of open procedures.¹⁵ Preliminary results suggested that the MIS posterior lumbar fusion procedures hold the promise of decreased iatrogenic muscle injury and approach-related morbidity, while achieving the same surgical goals as CO-TLIF.¹⁶ Our study was performed to objectively assess the amount of reduction in LMM of the MFM at the operated level in CO-TLIF as compared to MIS-TLIF using MRI scans.

The deflection of muscle from the spinal processes, and subsequent prolonged wide retraction of conventional lumbar fusion may lead to ischemia and denervation of the paraspinal musculature. This in turn may be associated with postoperative muscle atrophy and pain.¹⁷ The MFM represents the deepest muscle group of the lumbar spine. Principal action of the MFM is rotation in sagittal plane. Force exerted by paraspinal muscles stiffens the functional lumbar spinal unit, with MFM having the highest influence.¹⁸ Wilke et al.¹⁹ examined action of simulated muscle force of MFM on motion segment stiffness. Compared with sacrospinalis and psoas, MFM contributed two-thirds of the increased stiffness imparted by the simulated contraction of paraspinal muscles. Therefore, wasting of this muscle would be expected to have direct effects on lumbar segmental stability, and thus predispose to further damage. The MFM is most vulnerable to damage during posterior spinal surgery, as its innervated only by medial branch of dorsal ramus²⁰ and has no inter-segmental nerve supply unlike other paraspinals. The medial branch of dorsal ramus is vulnerable to compression during lateral displacement of muscle mass at surgery, particularly where the nerve is relatively fixed as it runs under the fibro-osseous mamillo-accessory ligament.^20,21 Patients with postoperative failed back syndrome have dorsal ramus lesions in 1 or more segments covered by fibrosis with local paraspinal muscle atrophy at corresponding segments. Dysfunction of MFM may contribute to “fusion disease.” This term is used for patients having successful fusion on radiographs but clinical outcome is poor.²²

Histologic, enzymatic, and radiologic evidences of paraspinal muscle injury in lumbar surgery have described by several authors. Kawaguchi et al²³ analyzed effects of retractor blade pressure on paraspinal muscles during spinal surgery. They determined that elevated serum levels of creatine phosphokinase MM isoenzyme, an indicator of muscle injury is directly related to retraction pressure and duration. Gejo et al²⁴ examined postoperative MRIs and trunk muscle strength in 80 patients who had undergone lumbar surgery. They concluded that injury to lumbar musculature was directly proportional to intra-operative retraction time. Furthermore, incidence of low back pain was significantly increased in patients with longer muscle retraction times. Kahanovitz et al demonstrated a 30% decrease²⁵ in lumbar isokinetic strength on flexion test, even after short microdiscectomy procedures in young, healthy males. Rantanen et al²⁶ saw persistent pathologic changes in paraspinal muscles in patients with poor outcomes after lumbar spine surgery. Previous literature has reported that dissection/ retraction of MFM can lead to denervation and atrophy. This in turn may lead to increased risk of failed back surgery syndrome.^27,28 Minimally invasive spine was developed as a potential solution to the above-mentioned problems by reducing the amount of iatrogenic soft-tissue injury while still accomplishing the traditional goals of the open procedure.^29,30

We found that the mean reduction in LMM in the MIS-TLIF group was significantly less than that in the CO-TLIF group. This correlates with some of the findings in previously published literature (Table 1) where authors have compared the MFM damage between CO-TLIF and MIS-TLIF utilizing various modalities. All measurements in our study were performed using the ImageJ image processing program. ImageJ^10,11is a Java-based image processing program developed at the National Institutes of Health and the Laboratory for Optical and Computational Instrumentation (LOCI, University of Wisconsin). It can read multiple image file formats, including JPEG.³¹ It can calculate area and pixel value statistics of user-defined selections and intensity-threshold objects, which is what we utilized. The image format used was JPEG.^10,11,31 In our study, some images were direct from PACS while others were clicked with a camera which is one of the potential limitations of the study.

Table 1.

Review of Literature Showing Previously Published Articles Comparing Paraspinal Muscle Damage in MIS vs CO-TLIF Group.

Sr. No	Author	Sample Size	Outcome Measures	Conclusions
1	Fan et al¹	59	VAS, ODI score, creatine kinase level, CSA of lean MFM, and the T2 signal intensity ratio of multifidus to psoas muscle	MIS caused less change in MFM, less postoperative back pain and functional disability than conventional open approach.
2	Stevens et al⁸	8	Maximum IMP generated using an ultra-miniature pressure Transducer. MRI: Edema and atrophy within multifidus, with T2 mapping and diffusion-weighted imaging	Peak IMP generated by MIS retractor was significantly less than with CO. Postoperatively, less muscle edema was demonstrated after MIS lumbar spinal fusion.
3	Hyun et al⁴¹	29	CSA, thickness, and width of the MFM were measured by CT.	The degree of postoperative paraspinal muscle atrophy was significantly greater on the MA side than on the contralateral PIA side (−20.7% and −4.8%, respectively, P < .01).
4	Kim et al¹⁷	19	CSA and T2-weighted signal intensity of MFM was measured by MRI and trunk extension muscle strength [Medx back extension machine (Ocala, FL)].	Percutaneous pedicle screw fixation caused less paraspinal muscle damage than CO pedicle screw fixation and had positive effects on postoperative Trunk muscle performance.
5	Min et al³⁰	48	Quantitative analysis of the change in fat infiltration percentage and the change in CSA of paraspinal muscle, before and after surgery using the pseudo coloring technique	Both single and multi-segment fusion showed less change in fat infiltration percentage and cross-sectional area in the MI-TLIF as compared to CO-TLIF

[Abbreviations: VAS- visual analogue scale, ODI- Oswestry Disability Index, CSA- Cross-Sectional Area, MIS- minimally invasive spine, MFM- Multifidus muscle, IMP- Intra Muscular Pressure, MRI- Magnetic Resonance Imaging, CT- Computed Tomography, CO- Conventional Open, TLIF- Transforaminal Lumbar Interbody Fusion, MA- Midline Approach, PIA- Paramedian Interfascial Approach].

We observed a significant but weak degree of correlation between age and percentage reduction of LMM. Increasing age was associated with greater percentage reduction in LMM. As per our knowledge, none of the previously published papers have specifically assessed the impact of age and MFM atrophy. This assumes significance with changing demographics both in India and world over.^32,33 India’s elderly population (aged 60 and above) is projected to touch 194 million in 2031 as compared to 138 million in 2021. This would be a steep 41% increase in,^34-36 as per the National Statistical Office (NSO)’s Elderly in India 2021 report. With changing demographics, sarcopenia has been the focus of current research in orthopedics and spine surgery. In 1989, Rosenberg proposed the term “sarcopenia” (Greek “sarx” or flesh + “penia” or loss)^37,38 to describe this age-related decrease of muscle mass. Sarcopenia is defined as a loss of skeletal muscle mass and function primarily associated with aging.³⁹ Yolcu et al investigated operative and postoperative outcomes associated with CO and MIS techniques in elderly patients.⁴⁰ This study included 107 patients with age more than 65. The authors found that intra-operative blood loss, length of hospital stay, rate of complications, readmissions (no readmissions in MIS group), reoperations, and pain improvement all favored the MIS group. Apart from these previously published advantages, our study found 1 more factor favoring MIS, given this age group also has associated sarcopenia. With greater postoperative fibrosis in CO-TLIF patients with aging, MIS can be a better option in elderly particularly to avoid MFM atrophy.

We had a greater reduction in LMM in female patients as compared to males and the difference was statistically significant. This correlates with previously published literature that has assessed gender differences in paraspinal muscle structure and function. Hyun et al⁴¹ compared the paramedian interfascial approach (PIA) to traditional midline approach (MA) for lumbar fusion to assess paraspinal muscle damage. They found that the cross-sectional area (CSA) and thickness of the paraspinal muscles did not change significantly after the surgery on side of PIA, but reduced remarkably on that of MA, especially in female patients. Chua et al⁴² assessed gender differences in fatty infiltration and sarcopenia in patients with lumbar spinal stenosis. They retrospectively analyzed 63 patients with lumbar spinal stenosis at L3/4 or L4/5 who underwent MIS decompression. They concluded that female patients develop more severe and functionally significant MFM atrophy. This in turn has worse clinical outcomes and higher functional disability. Though we do not know the exact reason behind this phenomenon, there have been studies performed previously that looked at gender differences in paraspinal muscle architecture. To investigate the effects of gender on the dimensions of spinal and paraspinal structures, Cooper et al⁴³ made anthropometric assessments on 92 patients (39 females and 53 males, aged 20-55 years) suffering from low back pain. CSA of L4 and paraspinal/ psoas muscles were measured at level of upper table of L4. They found greater CSA of all structures in males.

The mean percentage reduction in LMM on side of cage insertion was greater than the opposite side in both MIS and CO-TLIF groups and this difference was statistically significant. This can be explained by the fact that there was greater amount of surgical work done on the side of cage insertion as compared to the contra-lateral side. Also, the cage is usually inserted from the side with greater severity of symptoms. Chon et.al.⁴⁴ observed that CSA of paraspinal muscles at L4-5 and L5–S1 levels was less on affected side as compared to uninvolved side in patients with unilateral radiculopathy for more than 3 months. This asymmetric atrophy of paraspinal muscles in patients with chronic unilateral lumbar radiculopathy may have led to the greater degree of MFM atrophy on the side of cage insertion.

There are some limitations in the present study that deserve mention. Firstly, this study was a single centre analysis and was not randomized or controlled. It was a radiological study only with no clinical correlation or functional evaluation of MFM. The study though prospective in nature, did not include consecutive patients. Only those patients who consented for participation and a follow-up MRI evaluation were included. Despite these limitations, our study is the largest one in terms of sample size, comparing MFM fibrosis in CO vs MIS-TLIF, in currently published literature. It will provide a baseline for future research on the subject including gender differences in LMM reduction and role of MFM atrophy and correlation with adjacent segment degeneration.

Conclusion

The mean reduction in LMM is greater in the CO-TLIF group as compared to MIS-TLIF. There was a greater reduction in LMM in females as compared to males and on the side of cage insertion. We also found significant but weak degree of correlation between greater reduction in LMM with increasing age in both the groups.

Footnotes

Declaration of Conflicting Interests

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Funding

The author(s) received no financial support for the research, authorship, and/or publication of this article.

Informed Consent

Informed consent taken from all the study participants for use of their clinical data as well as images.

ORCID iDs

Nandan Marathe

Shivanand Mayi

Devanand Degulmadi

Ravi Ranjan Rai

Kirit Jadav

Prarthan Amin

Ajay Krishnan

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Does Conventional Open TLIF cause more Muscle Injury when Compared to Minimally Invasive TLIF?—A Prospective Single Center Analysis

Abstract

Study design

Objectives

Methods

Results

Conclusion

Keywords

Introduction

Methods

Results

Discussion

Conclusion

Footnotes

Declaration of Conflicting Interests

Funding

Informed Consent

ORCID iDs

References