This study aims to investigate whether elevated human neutrophil peptides 1–3 (HNP 1–3) levels in cerebrospinal fluid (CSF) are associated with disease severity and clinical outcomes in patients with intracerebral hemorrhage (ICH).
Materials and Methods:
HNP 1–3 levels were measured in CSF samples collected within 3 days after hemorrhage onset in ICH patients and control subjects.
Results:
HNP 1–3 levels were significantly higher in ICH patients with moderate-severe coma and hematoma volume >30 mL group. Univariate and multivariate logistic regression analyses demonstrated that CSF HNP 1–3 levels were associated with unfavorable outcomes. Receiver operating characteristic analysis revealed that CSF HNP 1–3 concentrations >466.95 ng/mL could distinguish ICH patients at risk for an unfavorable prognosis.
Conclusions:
HNP 1–3 exhibit satisfactory diagnostic efficiency for predicting the prognosis of ICH patients.
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