Abstract
Although the edible alga Petalonia binghamiae is extensively consumed as a health-promoting food by Northeast Asians, little is known about the biomedical efficacies of P. binghamiae. In this report, we investigated the novel efficacy of P. binghamiae extract (Pb-E01) using LX-2 and HepG2 cells. Pb-E01 inhibited TGF-β1-induced cell proliferation and gene expression in LX-2 cells. In addition, Pb-E01 reduced H2O2–induced reactive oxygen species (ROS) and alanine aminotransferase (ALT) activity in HepG2 cells. According to these results, we suggest that Pb-E01 plays a functional role in suppressing liver fibrogenesis.
