Four new oleanane saponins (1-4), together with three known saponins, were isolated from the aerial parts of Dizygotheca elegantissima R. Vig. & Guillaumin. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all isolated compounds was evaluated.
CioffiG, BracaA, AutoreG, MorelliI, PintoA, VenturellaF, De TommasiN. (2003) Cytotoxic saponins from Schefflera fagueti. Planta Medica, 69, 1–7.
2.
BracaA, AutoreG, De SimoneF, MarzoccoS, MorelliI, VenturellaF, De TommasiN. (2004) Cytotoxic saponins from Schefflera rotundifolia. Planta Medica, 70, 960–966.
3.
CioffiG, Dal PiazF, VassalloA, VenturellaF, De CaprariisP, De SimoneF, De TommasiN. (2008) Antiproliferative oleanane saponins from Meryta denhamii. Journal of Natural Products, 71, 1000–1004.
4.
MelekFR, MiyaseT, Abdel-KhalikSM, MahmoudII, MinaSA. (2004) Saponins and acylated saponins from Dizygotheca kerchoveana. Phytochemistry, 65, 3089–95.
5.
JiangW, LiW, HanL, LiuL, ZhangQ, ZhangS, NikaidoT, KoikeK. (2006) Biologically active triterpenoid saponins from Acanthopanax senticosus. Journal of Natural Products, 69, 1577–1581.
6.
PlunkettGM, SoltisDE, SoltisPS. (1996) Higher level relationships of Apiales (Apiaceae and Araliaceae) based on phylogenetic analysis of rbcL sequences. American Journal of Botany, 83, 499–515.
7.
CioffiG, Dal PiazF, De CaprariisP, SanogoR, MarzoccoS, AutoreG, De TommasiN. (2006) Antiproliferative triterpene saponins from Entada africana. Journal of Natural Products, 69, 1323–1329.
8.
GreenLM, ReadeJL, WareCF. (1984) Rapid colorimetric assay for cell viability: application to the quantitation of cytotoxic and growth inhibitory lymphokines. Journal of Immunological Method, 70, 257–268.
9.
CioffiG, BaderA, MalafronteA, Dal PiazF, De TommasiN. (2008) Secondary metabolites from the aerial parts of Salvia palaestina Bentham. Phytochemistry, 69, 1005–1012.
10.
SawadaH, MiyakoshiM, IsodaS, IdaY, ShojiJ. (1993) Saponins from leaves of Acanthopanax sieboldianus. Phytochemistry, 34, 1117–1121.
11.
Abdel-GawadMM, El-SayedMM, Abdel-HameedES. (1997) Molluscicidal saponins from Dizygotheca elegantissima. Al-Azhar Journal of Pharmaceutical Sciences, 20, 52–65.
12.
CioffiG, VassalloA, LeporeL, VenturellaF, Dal PiazF, De TommasiN. (2008) Antiproliferative oleanane saponins from Polyscias guilfoylei. Natural Product Communicatins, 3, 1667–1670.
13.
MorelloS, PetrellaA, FestaM, PopoloA, MonacoM, VuttarielloE, ChiappettaG, ParenteL, PintoA. (2008) Cl-IB-MECA inhibits human thyroid cancer cell proliferation independently of A3 adenosine receptor activation. Cancer Biology & Thererapy, 7, 278–84
14.
MarianiC, BracaA, VitaliniS, De TommasiN, VisioliF, FicoG. (2008) Flavonoid characterization and in vitro antioxidant activity of Aconitum anthora L. (Ranunculaceae). Phytochemistry, 69, 1220–1226.