Structure – activity relationships (SAR) between modified eremophilanes and anti-inflammatory activity are reported. The compounds have shown antioxidant (DPPH model), hypoglycaemic, antihyperglucemic and antidiabetic effects in rats.
GuzmanJA, GarciaE, MendozaV, De JesúsD, MaldonadoLA. (2004) Estudio sintético de furanoeremofilanos. Síntesis de la normetil-9-oxoeuryopsina. Revista de la Sociedad Química de México, 48, 250–255.
2.
JiménezM, CruzR, ValdésJ, LeónJ, AlarcónG, SveshtaroveB. (1992) Actividad antimicrobiana del cacalol y sus derivados. Revista Latinoamericana de Química, 23, 14–17.
3.
KrasovaskayaNP, KuleshNI, DenisenkoV. (1989) Natural antioxidants: Furanoeremophilane from Cacalia roots, Khimiya Prirodnykh Soedinenii, 5, 643–646; Chemical Abstracts (1990) 112, 95533u.
4.
AnayaAL, Hernández-BautistaBE, Torres-BarragánA, León-CanteroJ, Jiménez-EstradaMJ. (1996) Phytotoxicity of cacalol and some derivatives obtained from the roots of Psacalium decompositum (A. Gray) H. Rob. & Brettell (Asteraceae), Matarique or Maturin. Journal of Chemical Ecology, 22, 393–403.
5.
Román-RamosR, LaraLA, Alarcón AguilarFJ, Flores SáenzJL. (1992) Hypoglycemic activity of some antidiabetic plants. Archives of Medicinal Research, 23, 105–109.
6.
AlarcónFJ, Román-RamosR, Jiménez-EstradaM, Reyes-ChilpaR, Gonzalez-ParedesB, Flores SáenzJL. (1997) Effects of three Mexican medicinal plants (Asteraceae) on blood glucose levels in healthy mice and rabbits. Journal of Ethnopharmacology, 55, 171–177.
7.
InmanWD, LuoJ, JoladSD, KingSR, CooperR. (1999) Antihyperglycemic sesquiterpenes from Psacalium decompositum. Journal of Natural Products, 62, 1088–1092;
8.
Alarcón AguilarFJ, Jiménez-EstradaM, Reyes-ChilpaR, González ParedesB, Contreras WeberCC, Román RamosR. (2000) Hypoglycemic activity of root water decoction, sesquiterpenoids, and one polysaccharide fraction from Psacalium decompositum in mice. Journal of Ethnopharmacology, 69, 207–215.
9.
RomoJ, Joseph-NathanP. (1964) The constituents of Cacalia decomposita (A. Gray). Structures of cacalol and cacalone. Tetrahedron, 20, 2331–2334.
10.
LinaresE, ByeRA. (1987) A study of four medicinal plant complexes of Mexico and adjacent United States. Journal of Ethnopharmacology, 19, 153–183.
11.
Pérez CastorenaAL, ArciniegasA, VillaseñorJL, Romo de VivarA. (2004) Furanoeremophilane derivatives from Psacalium beamanii. Revista de la Sociedad Química de México, 48, 21–23.
12.
Garduño-RamírezML, TrejoA, NavarroV, ByeR, LinaresE, DelgadoG. (2001) New modiefied eremophilanes from the roots of Psacalium radulifolium. Journal of Natural Products, 64, 432–435.
13.
Garduño-RamírezML, DelgadoG. (2003) New eremophilanoids from the roots of Psacalium radulifolium. Hypoglycemic, antihyperglycemic and anti-oxidant evaluations. Revista de la Sociedad Química de México, 47, 155–159.
14.
Jiménez-EstradaM, Reyes ChilpaR, Ramirez ApanT, LlediasF, HansbergW, ArrietaD, Alarcon AguilarFJ. (2006) Anti-inflammatory activity of cacalol and cacalone sesquiterpenes isolated from Psacalium decompositumJournal of Ethnopharmacology, 105, 34–38.
15.
BeckeAD. (1988) Density-functional exchange-energy approximation with correct asymptotic behavior. Physical Review A, 38, 3098–3100.
16.
LeeC, YangW, ParrRG. (1988) Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. Physical Review B, 37, 785–789.
KierLB. (1970) Molecular Orbital Studies in Chemical Pharmacology, Springer, Berlin.
19.
KorolkovasA. (1982) Fundamentos da Farmacologia Molecular, Guanabara Dois S.A., Rio de Janeiro.
20.
BurgerA. (1970) Medicinal Chemistry. Wiley–Interscience, New York.
21.
AllingerNL, YuhYH, LiiJH. (1989) Molecular mechanics. The MM3 force field for hydrocarbons. 1. Journal of the American Chemical Society, 111, 8551–8566.
22.
OstlundNS. (1995) HyperChem: Program for molecular visualization and simulation. University of Waterloo, Canada.
23.
OstlundNS. (1994) Hypercube. ChemPlus: Extensions for HyperChem, Ontario.
24.
LeachAR. (1996) Molecular Modelling: Principles and Applications, Addison Wesley and Longman Ltd., Essex. 102–103.
25.
DamuAG, KuoPC, SuCR, KuoTH, ChenTH, BastowKF, LeeKH, WuTS. (2007) Isolation, structures, and structure-cytotoxic activity relationships of withanolides and physalins from Physalis angulata. Journal of Natural Products, 70, 1146–1152.
26.
KlebeG, AbrahamA, MietznerT. (1994) Molecular similarity indices in a comparative analysis (CoMSIA) of drug molecules to correlate and predict their biological activity. Journal of Medicinal Chemistry, 37, 4130–4146.
27.
MolfettaFA, HonórioKM, AlvesCN, Da SilvaABF. (2004) A study on the anti-HIV activity of biflavonoid compounds by using quantum chemical and chemometric methods. Journal of Molecular Structure (TheoChem), 674, 191–197.
28.
OhtsuH, XiaoZ, IshidaJ, NagaiM, WangH, ItokawaH, SuCh, ShihCh, ChiangT, ChangE, LeeY, TsaiM, ChangCh, LeeK. (2002) Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents. Journal of Medicinal Chemistry, 45, 5037–5042.
29.
QadeerG, Hasan RamaH, HillRA, Garduño-RamírezML. (2007) Synthesis and anti-inflammatory activity of fluorinated isocoumarins and 3,4-dihydroisocoumarins. Journal of Fluorine Chemistry, 128, 641–646.