Abstract
Background: The HIV pandemic is one of the greatest challenges facing humanity, and generations may be wiped out if effective prevention, treatment, and care are not in place. Case reports: A total of 3 families are presented. In the first 2, the children represented the third generation in their families to be infected with HIV and probably had mother-to-child transmission of the disease. The children in the third family were HIV negative. The mothers and grandmothers in all the families were infected with HIV. Risky sexual behavior involving multiple sexual partnering was recorded among them, some of whom had died from AIDS-related illness. This has serious implications in the care of the infected and affected children as they had been made vulnerable by their circumstances. Conclusion: HIV/AIDS has been around long enough now to cross generations as shown in the reported cases, which resulted in serious health and socioeconomic effects in the affected families.