Transgenic mice: What are we learning about gene function and neurological disease?

Martin JB , Longo FM Molecular neurobiology. In: Jameson JL , editor. Textbook of molecular medicine. Cambridge, MA: Blackwell 1996; in press.

Brookfield J. Can genes be truly redundant ? Curr Biol 1992;2:553-554.

Sibilia M. , Wagner EF Strain-dependent epithelial defects in mice lacking the EGF receptor . Science 1995;269:234-238.

Threadgill DW , Dlugosz AA , Hansen LA , et al. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 1995;269:230-234.

Takahashi R. , Yokoji H. , Misawa H. , Hayashi M. , Hu J. , Deguchi T. A null mutation in the human CNTF gene is not causally related to neurological diseases. Nat Genet 1994 ;7:79-84.

Hsiao KH , Scott M. , Foster D. , Groth DF , DeArmond SJ , Prusiner SB Spontaneous neurodegeneration in transgenic mice with mutant pnon protein . Science 1990;250:1587-1590.

Muller U. , Cnstina N. , Li Z-W. , et al. Behavioral and anatomical deficits in mice homozygous for a modified β-amyloid precursor gene. Cell 1994;79:755-765.

LaFerla FM , Tinkle BT , Biebench CJ , Haudenschild CC , Jay G. The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat Genet 1995;9:21-30.

Games D. , Adams D. , Alessandrim R. , et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 1995;373:523-527.

Gurney ME , Pu H. , Chiu AY , et al. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 1994 ,264:1772-1775

Xu Z. , Cork LC , Griffin JW , Cleveland DW Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease. Cell 1993;73:23-33.

Brannan CI , Perkins AS , Vogel KS , et al. Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues . Genes Dev 1994;8:1019-1029.

Giese KP , Martini R. , Lemke G. , Soriano P. , Schachner M. Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons . Cell 1992;71: 565-576.