The first two observations of human poisoning involving the recently developed neuroleptic amisulpride are described. In both cases drug determination was per formed using reversed-phase HPLC coupled with diode- array detection. Case 1 was a nonfatal overdosage in which the ingestion of 3.0 g amisulpride induced an attack of seizures, then light coma with agitation, hyperthermia, mydriasis, minimal extrapyramidal features, tachycardia and slight prolongation of the QT interval; the blood con centration of amisulpride was 9.63 μg ml-1. Case 2 was a fatality attributed to amisulpride in which the measured blood concentration was 41.70 μg ml-1. Our results are discussed in the light of data previously reported on the toxicity of substituted benzamides.