Abstract
Endothelial-specific Crif1 deletion induces BBB maturation and disruption via the alteration of actin dynamics by impaired mitochondrial respiration by M Joung Lee, Y Jang, J Han et al. J Cereb Blood Flow Metab. Epub ahead of print 27 January 2020. DOI: 10.1177/0271678X19900030.
The title for this article has changed to:
Endothelial-specific Crif1 deletion leads to BBB immaturation and disruption via the alteration of actin dynamics by impaired mitochondrial respiration.
The following sentences have also been updated:
Abstract
“We clearly observed defects in motor behavior, uncompacted myelin and leukocyte infiltration caused by BBB maturation and disruption in this mice.” to “We clearly observed defects in motor behavior, uncompacted myelin and leukocyte infiltration caused by BBB immaturation and disruption in this mice”.
Introduction
“We hypothesized that Crif1 deletion in ECs leads to BBB maturation and disruption through mitochondrial dysfunction because ECs in the BBB have much more mitochondria than other ECs.” to “We hypothesized that Crif1 deletion in ECs leads to BBB immaturation and disruption through mitochondrial dysfunction because ECs in the BBB have much more mitochondria than other ECs.”
Results
“For this reason, we focused on ECs in the BBB. Since Crif1 deletion in ECs decreased the number of blood vessels in brain, we performed tubeformation assays and investigated the levels of the angiogenesis-related genes, Angpt2 and Vegf, using the bEnd.3 cell line to verify whether deletion of Crif1 in ECs causes brain angiogenesis and vascular maturation (Supplementary Figure 3(e)).” to “For this reason, we focused on ECs in the BBB. Since Crif1 deletion in ECs decreased the number of blood vessels in brain, we performed tubeformation assays and investigated the levels of the angiogenesis-related genes, Angpt2 and Vegf, using the bEnd.3 cell line to verify whether deletion of Crif1 in ECs affects brain angiogenesis and vascular immaturation (Supplementary Figure 3(e)).”
“As shown in Figure 6(g), an EC-specific Crif1 deficiency resulted in BBB maturation and disruption.” to “As shown in Figure 6(g), an EC-specific Crif1 deficiency resulted in BBB immaturation and disruption.”