Based on the emerging interest in the effects of gut microbiota on cognition, this proof-of-concept study assessed how children aged 7 to 9 with low reading scores responded to the ingestion of a 3-month prebiotic supplement versus a placebo. As a secondary aim, the effects of the prebiotic on cognition, sleep, behaviour, mood, anxiety, and cortisol were assessed. In this sample, the prebiotic did not affect any of the outcome measures.
DesmedtOBroersVZamariolaG, et al. (2019) Effects of prebiotics on affect and cognition in human intervention studies. Nutr Rev77(2): 81–95.
2.
GronierBSavignacHMDi MiceliM, et al. (2018) Increased cortical neuronal responses to NMDA and improved attentional set-shifting performance in rats following prebiotic (B-GOS®) ingestion. Eur Neuropsychopharmacol28: 211–224.
3.
MontgomeryPBurtonJRSewellRP, et al. (2014) Fatty acids and sleep in UK children: Subjective and pilot objective sleep results from the DOLAB study–a randomized controlled trial. J Sleep Res23: 364–388.
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MontgomeryPSpreckelsenTFBurtonA, et al. (2018) Docosahexaenoic acid for reading, working memory and behavior in UK children aged 7-9: A randomized controlled trial for replication (the DOLAB II study). PLoS One13: 1–26. e0192909.
5.
OhayonMMCarskadonMAGuilleminaultC, et al. (2004) Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: Developing normative sleep values across the human lifespan. Sleep27: 1255–1273.
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OliverosERamirezMVazquezE, et al. (2016) Oral supplementation of 2′-fucosyllactose during lactation improves memory and learning in rats. J Nutr Biochem31: 20–27.
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SchmidtKCowenPJHarmerCJ, et al. (2015) Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers. Psychopharmacology232: 1793–1801
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SmithAPSutherlandDHewlettP (2015) An investigation of the acute effects of Oligofructose-enriched inulin on subjective wellbeing, mood and cognitive performance. Nutr7(11): 8887–8896.
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WilliamsSChenLSavignacHM, et al. (2016) Neonatal prebiotic (BGOS) supplementation increases the levels of synaptophysin, GluN2A-subunits and BDNF proteins in the adult rat hippocampus. Synapse70: 121–124.
