strains could increase the risk for atrial fibrillation in patients with coronary artery disease
Methods
Serological status for H. pylori CagA using enzyme-linked immunosorbent assay, C-reactive protein, total leucocytic count and atrial size were determined in 185 coronary artery disease patients (with and without atrial fibrillation) and 80 healthy subjects (control).
Results CagA
strain showed a higher prevalence in the atrial fibrillation group. Atrial dimension and C-reactive protein (independent predictors of atrial fibrillation) were significantly increased in the CagA seropositive subgroup Conclus ons There is a strong liaison between H. pylori CagA infection and atrial fibrillation in coronary artery disease. Increased C reactive protein and atrial size in atrial fibrillation patients may reflect atrial inflammatory remodeling.
GaudinoMAndreottiFZamparelliRDi CastelnuovoANassoGBurzottaF. The −174G/C interleukin-6 polymorphism influences postoperative interleukin-6 levels and postoperative atrial fibrillation: is atrial fibrillation an inflammatory complication? Circulation2003; 108 (Suppl II):II195–II199.
2.
PhangRSIssermanSMKariaDPandianNGHomoudMKLinkMS. Echocardiographic evidence of left atrial abnormality in young patients with lone paroxysmal atrial fibrillation. Am J Cardiol2004; 94:511–513.
3.
MonteneroASMollichelliNZumboFAntonelliADolciABarberisM. Helicobacter pylori and atrial fibrillation: a possible pathogenic link. Heart2005; 91:960–961.
4.
KoenigWRothenbacherDHoffmeisterAMillerMBodeGAdlerG. Infection with Helicobacter pylori is not a major independent risk factor for stable coronary heart disease: lack of a role of cytotoxin-associated protein A-positive strains and absence of a systemic inflammatory response. Circulation1999; 100:2326–2331.
5.
PasceriVCammarotaGPattiGCuocoLGasbarriniAGrilloRL. Association of virulent Helicobacter pylori strains with ischemic heart disease. Circulation1998; 97:1675–1679.
6.
GrunfeldCAdiSSouedMMoserAFiersWFeingoldKR.Search for mediators of the lipogenic effects of tumor necrosis factor: potential role for interleukin-6. Cancer Res1990; 50:4233–4238.
7.
MachFSchoenbeckUBonnefoyJYPoberJSLibbyP.Activation of monocyte/ macrophage functions related to acute atheroma compication by ligation of CD40: induction of collagenase, stromelysin, and tissue factor. Circulation1997; 96:396–399.
8.
KiechlSLorenzEReindlMWiedermannCJOberhollenzerFBonoraE. Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med2002; 347:185–192.
9.
AmerisoSFFridmanEALeiguardaRCSevleverGE.Detection of Helicobacter pylori in human carotid atherosclerotic plaques. Stroke2001; 32:385–391.
10.
KowalskiMReesWKonturekPCGroveRScheffoldTMeixnerH. Detection of Helicobacter pylori specific DNA in human atheromatous coronary arteries and its association to prior myocardial infarction and unstable angina. Dig Liver Dis2002; 34:398–402.
11.
SuerbaumSMichettiP.Helicobacrer pylori infection. N Engl J Med2002; 347:1175–1186.
12.
GaudinoMAndreottiFZamparelliRDi CastelnuovoANassoGBurzottaF. The −174G/C interleukin-6 polymorphism influences postoperative interleukin-6 levels and postoperative atrial fibrillation: is atrial fibrillation an inflammatory complication? Circulation2003; 108 (Suppl II):II195–II199.
13.
PhangRSIssermanSMKariaDPandianNGHomoudMKLinkMS. Echocardiographic evidence of left atrial abnormality in young patients with lone paroxysmal atrial fibrillation. Am J Cardiol2004; 94:511–513.
14.
MonteneroASMollichelliNZumboFAntonelliADolciABarberisM. Helicobacter pylori and atrial fibrillation: a possible pathogenic link. Heart2005; 91:960–961.
15.
KoenigWRothenbacherDHoffmeisterAMillerMBodeGAdlerG. Infection with Helicobacter pylori is not a major independent risk factor for stable coronary heart disease: lack of a role of cytotoxin-associated protein A-positive strains and absence of a systemic inflammatory response. Circulation1999; 100:2326–2331.
16.
PasceriVCammarotaGPattiGCuocoLGasbarriniAGrilloRL. Association of virulent Helicobacter pylori strains with ischemic heart disease. Circulation1998; 97:1675–1679.
17.
GrunfeldCAdiSSouedMMoserAFiersWFeingoldKR.Search for mediators of the lipogenic effects of tumor necrosis factor: potential role for interleukin-6. Cancer Res1990; 50:4233–4238.
18.
MachFSchoenbeckUBonnefoyJYPoberJSLibbyP.Activation of monocyte/ macrophage functions related to acute atheroma compication by ligation of CD40: induction of collagenase, stromelysin, and tissue factor. Circulation1997; 96:396–399.
19.
KiechlSLorenzEReindlMWiedermannCJOberhollenzerFBonoraE. Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med2002; 347:185–192.
20.
AmerisoSFFridmanEALeiguardaRCSevleverGE.Detection of Helicobacter pylori in human carotid atherosclerotic plaques. Stroke2001; 32:385–391.
21.
KowalskiMReesWKonturekPCGroveRScheffoldTMeixnerH. Detection of Helicobacter pylori specific DNA in human atheromatous coronary arteries and its association to prior myocardial infarction and unstable angina. Dig Liver Dis2002; 34:398–402.
22.
SuerbaumSMichettiP.Helicobacrer pylori infection. N Engl J Med2002; 347:1175–1186.
