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Research article

First published 2010-12

Comparison of Human Ether-à-go-go Related Gene Screening Assays Based on IonWorks Quattro and Thallium Flux

Terry R. Bridal, Michael Margulis, Xin Wang [...]

ASSAY and Drug Development Technologies

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Research article

First published 2010-12

A Pharmacologically Validated,High-Capacity,Functional Thallium Flux Assay for the Human Ether-à-go-go Related Gene Potassium Channel

William A. Schmalhofer, Andrew M. Swensen, Brande S. Thomas [...]

ASSAY and Drug Development Technologies

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Research article

First published 2024-6

Electrophysiological Changes in the Rabbit Ventricular Wedge and Human-Induced Pluripotent Stem-Cell Derived (IPSC) Cardiomyocytes Translate to Severe Arrhythmia Observed in a Canine Toxicology Study,Not Predicted by Standard In Vitro Ion Channel Assays

Alan P. Brown, Gregory S. Friedrichs, Hai-Ming Tang [...]

International Journal of Toxicology

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Research article

First published 2005-03

Identifying Modulators of hERG Channel Activity Using the PatchXpress® Planar Patch Clamp

Adrienne E. Dubin, Nadia Nasser, Jutta Rohrbacher [...]

Journal of Biomolecular Screening

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Research article

First published 2006-1

Utility of hERG Assays as Surrogate Markers of Delayed Cardiac Repolarization and QT Safety

Gary A. Gintant, Zhi Su, Ruth L. Martin [...]

Toxicologic Pathology

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Research article

First published 2007-06

A Cell-Based Rb + -Flux Assay of the Kv1.3 Potassium Channel

Sikander Gill, Rajwant Gill, David Wicks [...]

ASSAY and Drug Development Technologies

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Research article

First published 2022-5

Investigational New Drug Enabling Nonclinical Safety Pharmacology Assessment of the Iminosugar UV-4,a Broad-Spectrum Host-Targeted Antiviral Agent

Jeffry Shearer, Gary Wolfe, Aruna Sampath [...]

International Journal of Toxicology

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Research article

First published 2021-10

Nonclinical Safety Profile of Sotorasib,a KRAS G12C -Specific Covalent Inhibitor for the Treatment of KRAS p.G12C -Mutated Cancer

Katsu Ishida, Jonathan A. Werner, Rhian Davies [...]

International Journal of Toxicology

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Research article

First published 2012-7

Development of Recombinant Cell Line Co-expressing Mutated Nav1.5,Kir2.1,and hERG for the Safety Assay of Drug Candidates

Masato Fujii, Susumu Ohya, Hisao Yamamura [...]

Journal of Biomolecular Screening

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Research article

First published 2015-7

A High-Throughput Electrophysiology Assay Identifies Inhibitors of the Inwardly Rectifying Potassium Channel K ir 7.1

Paul D. Wright, Srinivasan Kanumilli, David Tickle [...]

Journal of Biomolecular Screening

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