Sage Journals: Discover world-class research

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Research article

First published 2019

Shared Learnings on the New EMA First-in-Human and Early Clinical Trial Guideline: Proceedings From a DIAlogue Session at DIA Europe 2018

Jan Willem van der Laan, Charles T. Benson, Walter Janssens [...]

Therapeutic Innovation & Regulatory Science

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Research article

First published 2026-1

First-in-human gene therapy clinical trials in the media: Exploring patient narratives

Rachele E. Willard, Marilyn S. Baffoe-Bonnie, Hasmin C. Ramirez [...]

Public Understanding of Science

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Research article

First published 2025-10

First-in-Human Clinical Trial of the WeFlow-JAAA Endograft System in Patients With Juxtarenal Abdominal Aortic Aneurysms

Jiang-Ping Gao, Hong-Peng Zhang, Jiang Xiong [...]

Journal of Endovascular Therapy

Open access

Research article

First published 2025

Rationale and design of the CORDIAL first-in-human clinical trial: A system for sorbent-assisted continuous flow peritoneal dialysis

Joost Christiaan de Vries, Maaike K van Gelder, Dian P Bolhuis [...]

Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis

Open access

Research article

First published 2021-12

First-in-Human Clinical Application of the Medyria TrackCath System in Endovascular Repair of Complex Aortic Aneurysms (ACCESS Trial): A Prospective Multicenter Single-Arm Clinical Trial

Nikolaos Floros, Tilo Kölbel, Nikolaos Tsilimparis [...]

Journal of Endovascular Therapy

Open access

Research article

First published 2021-1

Trust trumps comprehension,visceral factors trump all: A psychological cascade constraining informed consent to clinical trials: A qualitative study with stable patients

Michael Rost, Rebecca Nast, Bernice S Elger [...]

Research Ethics

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Research article

First published 2018-5

The Early Preclinical Development Program for Locally Administered Investigational Medicinal Products in Ophthalmology

Annick Toggenburger, Rebecca Trönnberg, Alexandra Galland [...]

Therapeutic Innovation & Regulatory Science

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Research article

First published 2020-10

Design and Rationale for First-in-Human Phase 1 Immunovirotherapy Clinical Trial of Oncolytic HSV G207 to Treat Malignant Pediatric Cerebellar Brain Tumors

Joshua D. Bernstock, Asim K. Bag, John Fiveash [...]

Human Gene Therapy

Free access

Research article

First published 2009-4

The EMEA Guideline on First-in-Human Clinical Trials and Its Impact on Pharmaceutical Development

Mark N. Milton, Christopher J. Horvath

Toxicologic Pathology

Open access

Research article

First published 2025

Notch pathway inhibition with crenigacestat (LY3039478) in a phase I first-in-human clinical trial for patients with relapsed or refractory non-Hodgkin lymphoma and B-cell chronic lymphocytic leukemia

Jean-Marie Michot, Zsofia Balogh, Jennifer R. Brown [...]

Therapeutic Advances in Drug Safety

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