Sage Journals: Discover world-class research

Open access

Research article

First published 2023-9

Design and synthesis of novel PDE4 inhibitors as potential candidates for antidepressant agents

Yingcong Yu, Yan Zhao, Yajing Wang [...]

Journal of Chemical Research

Open access

Research article

First published 2024-11

Design and synthesis of novel curcumin derivatives as potent PDE4 inhibitors for the treatment of depression

Haodong Zhou, Yulan Zhu, Xianfeng Huang

Journal of Chemical Research

Open access

Research article

First published 2018-11

Quantification of human brain PDE4 occupancy by GSK356278: A [ 11 C](R)-rolipram PET study

Jasper van der Aart, Cristian Salinas, Rahul Dimber [...]

Journal of Cerebral Blood Flow & Metabolism

Free access

Research article

First published 2006-1

Characterization of the Inflammatory Response to a Highly Selective PDE4 Inhibitor in the Rat and the Identification of Biomarkers that Correlate with Toxicity

Gregory N. Dietsch, Chris R. Dipalma, Russell J. Eyre [...]

Toxicologic Pathology

Free access

Research article

First published 2008-08

A Cell-Based PDE4 Assay in 1536-Well Plate Format for High-Throughput Screening

Steven A. Titus, Xiao Li, Noel Southall [...]

Journal of Biomolecular Screening

Free access

Review article

First published 2010-10

Apremilast: a novel PDE4 inhibitor in the treatment of autoimmune and inflammatory diseases

Georg Schett, Victor S. Sloan, Randall M. Stevens [...]

Therapeutic Advances in Musculoskeletal Disease

Open access

Research article

First published 2025

Prophylactic PDE4 and PDE4B inhibition reduce lesion size and neutrophil infiltration following ischemic stroke in male mice

Laura Ponsaerts, Lotte Alders, Melissa Schepers [...]

Journal of Cerebral Blood Flow & Metabolism

Free access

Research article

First published 2013-6

Selective Inhibition of PDE4 in Wistar Rats Can Lead to Dilatation in Testis,Efferent Ducts,and Epididymis and Subsequent Formation of Sperm Granulomas

Anke Heuser, Lars Mecklenburg, Deborah Ockert [...]

Toxicologic Pathology

Retricted access

Research article

First published 2016-08

PDE4 Inhibition by Rolipram Promotes Neuronal Differentiation in Human Bone Marrow Mesenchymal Stem Cells

I-Seul Joe, Goang-Won Cho

Cellular Reprogramming

Retricted access

Research article

First published 2018-02

Investigation of Lung Pharmacokinetic of the Novel PDE4 Inhibitor CHF6001 in Preclinical Models: Evaluation of the PreciseInhale Technology

Alessandro Fioni, Ewa Selg, Valentina Cenacchi [...]

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Search results