YehC. N.ChenM. F.LeeW. C.JengL. B.Prognostic factors of hepatic resection for hepatocellular carcinoma with cirrhosis: Univariate and multivariate analysis. J Surg Oncol81, 195–202 (2002). DOI: 10.1002/jso.10178.
3.
LeeH. S.KimJ. S.ChoiI. J.ChungJ. W.ParkJ. H.KimC. Y.The safety and efficacy of transcatheter arterial chemoembolization in the treatment of patients with hepatocellular carcinoma and main portal vein obstruction. A prospective controlled study. Cancer79, 2087–2094 (1997). DOI: 10.1002/(SICI)1097–0142(19970601)79:11<2087::AID-CNCR5>3.0.CO;2-M.
LiuL.CaoY.ChenC.ZhangX.McNabolaA.WilkieD.WilhelmS.LynchM.CarterC.Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res66, 11851–11858 (2006). DOI: 10.1158/0008-5472.
QinW.ShiY.ZhaoB.YaoC.JinL.MaJ.JinY.miR-24 regulates apoptosis by targeting the open reading frame (ORF) region of FAF1 in cancer cells. PloS One5, e9429 (2010). DOI:10.1371/journal.pone.0009429.
11.
LytleJ. R.YarioT. A.SteitzJ. A.Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTR. Proceedings of the National Academy of Sciences of the United States of America104, 9667–9672 (2007). DOI: 10.1073/pnas.0703820104.
12.
LewisB. P.BurgeC. B.BartelD. P.Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell120, 15–20 (2005). DOI: 10.1016/j.cell.2004.12.035.
GramantieriL.FerracinM.FornariF.VeroneseA.SabbioniS.LiuC. G.CalinG. A.GiovanniniC.FerrazziE.GraziG. L.CroceC. M.BolondiL.NegriniM.Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma. Cancer Res67, 6092–6099 (2007). DOI: 10.1158/0008–5472.CAN-06-4607.
15.
FornariF.GramantieriL.GiovanniniC.VeroneseA.FerracinM.SabbioniS.CalinG. A.GraziG. L.CroceC. M.TavolariS.ChiecoP.NegriniM.BolondiL.MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells. Cancer Res69, 5761–5767 (2009). DOI: 10.1158/0008–5472.CAN-08-4797.
16.
BaiS.NasserM. W.WangB.HsuS. H.DattaJ.KutayH.YadavA.NuovoG.KumarP.GhoshalK.MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib. J Biol Chem284, 32015–32027 (2009). DOI: 10.1074/jbc.M109.016774.
17.
MengF.HensonR.LangM.WehbeH.MaheshwariS.MendellJ. T.JiangJ.SchmittgenT. D.PatelT.Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. Gastroenterology130, 2113–2129 (2006). DOI: 10.1053/j.gastro.2006.02.057.
18.
MoriyamaT.OhuchidaK.MizumotoK.YuJ.SatoN.NabaeT.TakahataS.TomaH.NagaiE.TanakaM.MicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistance. Mol Cancer Ther8, 1067–1074 (2009). DOI: 10.1158/1535–7163.MCT-08-0592.
19.
ParkJ. K.LeeE. J.EsauC.SchmittgenT. D.Antisense inhibition of microRNA-21 or −221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma. Pancreas38, e190–199 (2009). DOI: 10.1097/MPA.0b013e3181ba82e1.
20.
ShimizuS.TakeharaT.HikitaH.KodamaT.MiyagiT.HosuiA.TatsumiT.IshidaH.NodaT.NaganoH.DokiY.MoriM.HayashiN.The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma. J Hepatol52, 698–704 (2010). DOI: 10.1016/j.jhep.2009.12.024.
21.
NakataniF.FerracinM.ManaraM. C.VenturaS.Del MonacoV.FerrariS.AlberghiniM.GrilliA.KnuutilaS.SchaeferK. L.MattiaG.NegriniM.PicciP.SerraM.ScotlandiK.miR-34a predicts survival of Ewing's sarcoma patients and directly influences cell chemo-sensitivity and malignancy. J Pathol226, 796–805 (2012). DOI: 10.1002/path.3007.
22.
FujitaY.KojimaK.HamadaN.OhhashiR.AkaoY.NozawaY.DeguchiT.ItoM.Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells. Biochem Biophys Res Commun377, 114–119 (2008). DOI: 10.1016/j.bbrc.2008.09.086.
23.
KojimaK.FujitaY.NozawaY.DeguchiT.ItoM.MiR-34a attenuates paclitaxel-resistance of hormone-refractory prostate cancer PC3 cells through direct and indirect mechanisms. Prostate70, 1501–1512 (2010). DOI: 10.1002/pros.21185.
24.
JiQ.HaoX.MengY.ZhangM.DesanoJ.FanD.XuL.Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres. BMC Cancer8, 266 (2008). DOI: 10.1186/1471–2407–8-266.
25.
VinallR. L.RipollA. Z.WangS.PanC. X.deVere WhiteR. W.MiR-34a chemosensitizes bladder cancer cells to cisplatin treatment regardless of p53-Rb pathway status. Int J Cancer130, 2526–2538 (2012). DOI: 10.1002/ijc.26256.
26.
ZekriA. R.BahnassyA. A.Abdel-WahabS. A.KhafagyM. M.LoutfyS. A.RadwanH.ShaarawyS. M.Expression of pro- and anti-inflammatory cytokines in relation to apoptotic genes in Egyptian liver disease patients associated with HCV-genotype-4. J Gastroenterol Hepatol24, 416–428 (2009). DOI: 10.1111/j.1440-1746.2008.05699.x.
27.
HungJ. H.TengY. N.WangL. H.SuI. J.WangC. C.HuangW.LeeK. H.LuK. Y.Induction of Bcl-2 expression by hepatitis B virus pre-S2 mutant large surface protein resistance to 5-fluorouracil treatment in Huh-7 cells. PLoS One6, e28977 (2011). DOI: 10.1371/journal.pone.0028977.
28.
BudhuA.JiaH. L.ForguesM.LiuC. G.GoldsteinD.LamA.ZanettiK. A.YeQ. H.QinL. X.CroceC. M.TangZ. Y.WangX. W.Identification of metastasis-related microRNAs in hepatocellular carcinoma. Hepatology47, 897–907 (2008). DOI: 10.1002/hep.22160.
TakeharaT.LiuX.FujimotoJ.FriedmanS. L.TakahashiH.Expression and role of Bcl-xL in human hepatocellular carcinomas. Hepatology34, 55–61 (2001). DOI: 10.1053/jhep.2001.25387.
31.
XiaL.ZhangD.DuR.PanY.ZhaoL.SunS.HongL.LiuJ.FanD.miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells. Int J Cancer123, 372–379 (2008). DOI: 10.1002/ijc.23501.
32.
TryndyakV. P.RossS. A.BelandF. A.PogribnyI. P.Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet. Mol Carcinog48, 479–487 (2009). DOI: 10.1002/mc.20484.
33.
LiN.FuH.TieY.HuZ.KongW.WuY.ZhengX.miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells. Cancer Lett275, 44–53 (2009). DOI: 10.1016/j.canlet.2008.09.035.
34.
PogribnyI. P.TryndyakV. P.BoykoA.Rodriguez-JuarezR.BelandF. A.KovalchukO.Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure. Mutation Research619, 30–37 (2007). DOI: 10.1016/j.mrfmmm.2006.12.006.
35.
PineauP.VoliniaS.McJunkinK.MarchioA.BattistonC.TerrisB.MazzaferroV.LoweS. W.CroceC. M.DejeanA.miR-221 overexpression contributes to liver tumorigenesis. Proc Natl Acad Sci U S A107, 264–269 (2010). DOI: 10.1073/pnas.0907904107.
36.
NallsD.TangS. N.RodovaM.SrivastavaR. K.ShankarS.Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells. PLoS One6, e24099 (2011). DOI: 10.1371/journal.pone.0024099.
37.
KastlL.BrownI.SchofieldA. C.miRNA-34a is associated with docetaxel resistance in human breast cancer cells. Breast Cancer Res Treat131, 445–454 (2012). DOI: 10.1007/s10549–011–1424-3.