We report the first known instance of the clinical use of 99mTc-mebrofenin hepatobiliary scintigraphy (HBS) for the optimization of radiotherapy treatment planning and for the follow-up of acute toxicity in a patient undergoing stereotactic body radiation therapy for hepatocellular carcinoma. In our experience, HBS allowed the identification and the sparing of more functioning liver areas, thus potentially reducing the risk of radiation-induced liver toxicity.
De BariBGuilletMMornexF[Stereotactic body radiation therapy (SBRT) in the treatment of liver metastases: state of the art]. Cancer Radiother2011;15 (1)72–76 [Article in French].
2.
FrancoPDe BariBCiammellaP; AIRO Giovani Italian Association of Radiation Oncology, Young Members Working Group. The role of stereotactic ablative radiotherapy in oncological and non-oncological clinical settings: highlights from the 7th Meeting of AIRO—Young Members Working Group (AIRO Giovani). Tumori2014;100 (6)e214–e219
3.
ScorsettiMClericiEComitoTStereotactic body radiation therapy for liver metastases. J Gastrointest Oncol2014;5 (3)190–197
4.
KalogeridiMAZygogianniAKyrgiasGRole of radiotherapy in the management of hepatocellular carcinoma: A systematic review. World J Hepatol2015;7 (1)101–112
5.
De BariBPointreauYRioEMirabelXMornexF[Normal tissue tolerance to external beam radiation therapy: liver]. Cancer Radiother2010;144-5344–349 [Article in French].
6.
PanCCKavanaghBDDawsonLARadiation-associated liver injury. Int J Radiat Oncol Biol Phys2010;763 SupplS94–S100
7.
YoonHILeeIJHanKHSeongJImproved oncologic outcomes with image-guided intensity-modulated radiation therapy using helical tomotherapy in locally advanced hepatocellular carcinoma. J Cancer Res Clin Oncol2014;140 (9)1595–1605
8.
De BariBSellalNMornexF[4D-CT scan and radiotherapy for hepatocellular carcinoma: role in the definition of internal target volume (ITV)]. Cancer Radiother2011;15 (1)43–48 [Article in French].
9.
MizuguchiTKawamotoMMeguroMHuiTTHirataKPreoperative liver function assessments to estimate the prognosis and safety of liver resections. Surg Today2014;44 (1)1–10
10.
de GraafWBenninkRJVeteläinenRvan GulikTMNuclear imaging techniques for the assessment of hepatic function in liver surgery and transplantation. J Nucl Med2010;51 (5)742–752
11.
GunvénPJonasEBlomgrenHUndetectable late hepatic sequelae after hypofractionated stereotactic radiotherapy for liver tumors. Med Oncol2011;28 (4)958–965
12.
ShenSJacobRBenderLWDuanJSpencerSAA technique using 99mTc-mebrofenin SPECT for radiotherapy treatment planning for liver cancers or metastases. Med Dosim2014;39 (1)7–11
13.
JanorayGMornexF[Follow-up after stereotactic body radiation therapy for liver tumours: A review of the literature and recommendations]. Cancer Radiother2015;196-7573–581 [Article in French.].
14.
WangPMChungNNHsuWCChangFLJangCJScorsettiMStereotactic body radiation therapy in hepatocellular carcinoma: optimal treatment strategies based on liver segmentation and functional hepatic reserve. Rep Pract Oncol Radiother2015;20 (6)417–424
15.
DykPWeinerABadiyanSMyersonRParikhPOlsenJEffect of high-dose stereotactic body radiation therapy on liver function in the treatment of primary and metastatic liver malignancies using the Child-Pugh score classification system. Pract Radiat Oncol2015;5 (3)176–182
16.
SeppenwooldeYEngelsmanMDe JaegerKOptimizing radiation treatment plans for lung cancer using lung perfusion information. Radiother Oncol2002;63 (2)165–177
17.
McGuireSMZhouSMarksLBDewhirstMYinFFDasSKA methodology for using SPECT to reduce intensity-modulated radiation therapy (IMRT) dose to functioning lung. Int J Radiat Oncol Biol Phys2006;66 (5)1543–1552
18.
HooverDAReidRHWongESPECT-based functional lung imaging for the prediction of radiation pneumonitis: a clinical and dosimetric correlation. J Med Imaging Radiat Oncol2014;58 (2)214–222
19.
WangDLiBWangZFunctional dose-volume histograms for predicting radiation pneumonitis in locally advanced non-small cell lung cancer treated with late-course accelerated hyperfractionated radiotherapy. Exp Ther Med2011;2 (5)1017–1022
