Restricted accessResearch articleFirst published online 1987-5
INTERRELATIONSHIPS BETWEEN THE HEART AND CENTRAL NERVOUS SYSTEM: LOCALIZATION OF NEURO-TRANSMITTERS AND IMAGING OF THEIR ASSOCIATED NUCLEI,INCLUDING THE RAPHE NUCLEI & THE LOCUS COERULEUS,AS WELL AS THE IMAGING OF THE HEART AND ITS REPRESENTATION AREAS IN SLICES OF THE HUMAN CENTRAL NERVOUS SYSTEM USING THE “BI-DIGITAL O-RING TEST” IMAGING METHOD
Using microscopic slides of specific tissues from the human body or pure substances including neuro-transmitters such as serotonin, dopamine, norepinephrine, etc., as reference control substances in the Bi-Digital O-Ring Test Molecular Identification Method, the author was able to localize and image normal and abnormal internal organs, and to localize and trace the distribution of neurotransmitters in the different parts of the central nervous system. Using microscopic slides of different parts of the heart, we were able to image the outline of the heart as well as the SA node, AV node, tricuspid valve, mitral valve, aortic valve, pulmonary valve, coronary arteries, and aorta and its branches, including the vertebral arteries, without using any bulky or expensive imaging instruments. Using serotonin as a reference control substance on the different parts of the central nervous system, it was possible to demonstrate the 6 well-known raphe nuclei and the locus coeruleus (which contains serotonin & norepinephrine), as well as the distribution of serotonin in the cerebrum and the cerebellum, all of which closely resembled previously published well-known neuroanatomical structures and distributions of neurotransmitters. As an extension of this work, possible representations of different internal organs on the central nervous system were examined using microscopic slides of different internal organs as reference control substances. The results indicated that the entire heart is represented primarily in the medulla oblongata, and that the SA node and the upper half of the left atrium are represented in the caudal end of the pons; the right side of the heart (i.e. R-atrium, AV node, tricuspid valve, R-ventricle) is represented on the right side of the medulla oblongata, and the left side of the heart (i.e. lower half of the L-atrium, mitral valve, L-ventricle) is represented on the left side of the medulla oblongata, and the upper half of the left atrium is represented in the caudal end of the left side of the pons. The bottoms of the ventricles are located near the spinal cord. Furthermore, the right and the left sides of the heart are represented in specific areas of each side of the right and left hemispheres of the cerebral cortex, and there are connecting pathways between the representation areas of identical parts of the heart, through the corpus callosum and other neuro-pathways.
OmuraY, Editorial: New simple early diagnostic methods using Omura’s “Bi-Digital O-Ring Dysfunction Localization Method” and acupuncture organ representation points, and their applications to the “Drug & Food Compatibility Test” for individual organs and to auricular diagnosis of internal organs -- Part 1, Acupuncture & Electro-Ther.Res., Int.J., 6:239-254, 1981.
2.
OmuraY, Editorial: Effects of an electrical field and its polarity on an abnormal part of the body or organ représentaion point associated with a diseased internal organ, and its influence on the “Bi-Digital O-Ring Test” (simple, non-invasive dysfunction localization method) & drug compatibility test -- part 1, Acupuncture & Electro-Ther.Res., Int.J., 7:209-246, 1982.
3.
OmuraYNisterukCJLoscoBroMHellerSIOmuraACookAWilliamsG, Non-invasive early diagnosis of cardiovascular diseases by the combined use of the “Bi-Digital O-Ring Test Dysfunction Localization Method,” organ representation points & minute notches & slurrings appearing in QRS complexes of wide frequency bandwidth ECG’s & selective high frequency wide bandwidth ECG’s,”, Japanese Heart Journal, 23:564-566, supplement, 1982.
4.
OmuraY, The “Bi-Digital O-Ring Test”: critical evaluation of its abnormal responses with laboratory tests including “blood pressure & blood flow method,” “blood chemistry”, etc. and “neurological method,”, Acupuncture & Electro-Ther.Res., Int.J., 8:37-43, 1983.
5.
OmuraYNisterukCJLoscoBroMHellerSIOmuraACookAWilliamsGSpenceD, Early non-invasive diagnosis of cardiovascular diseases using the “Bi-Digital O-Ring Test” and “selective high-frequency wide band ECG’s” in the presence or absence or abnormalities in standard ECG’s, p.176 in, Abstracts of 10th Int.Cong. on Electro-cardiology and 24th Tnt. Symposium on Vectorcardiography, Bratislava, Czechoslovakia, August16-191983.
6.
OmuraY, Highlights of the forthcoming 1st international symposium on acupuncture & electrotherapeutics to celebrate 10th anniversary of Acupuncture & Electro-therapeutics Research, the International Journal. 1) Stress & immunity and effects of stimulation of deep peroneal nerve at st.36 on ventricular arrhythmia, heart disease & sudden death. 2) New simple accurate and inexpensive imaging technique of internal organs and cancer tissue by a clinical application of “Bi-Digital O-Ring Test” and clinical significance of newly discovered networks of thymus glands in cancer treatment, Acupuncture & Electro-Ther.Res., Int.J., 10:1-12, 1985.
7.
OmuraY, Simple and quick non-invasive evaluation of circulatory condition of cerebral arteries by clinical application of the “Bi-Digital O-Ring Test”, Acupuncture & Electro-Ther. Res., Int. J., 10:3;139-161, 1985.
8.
OmuraY, Simple method of estimating the presence of bacterial infection at different organs of humans & animals: effective antibiotics & their optimal dose; and potential infection from air conditioner filters, by the “Bi-Digital O-Ring Test”, Acupuncture & Electro-Ther.Res., Int, J., 10:3;214-215, (abstract), 1985.
9.
HidaK, Combining Korean Hand Acupuncture with Omura’s “Bi-Digital O-Ring Test,”Ido-No-Nippon, The Journal of Japanese Acupuncture and Moxibustion, 10:38-44, 1985.
OmuraY, A new, simple, non-invasive imaging technique of internal organs and various cancer tissues using extended principles of the “Bi-Digital O-Ring Test” without using expensive imaging instruments or exposing the patient to any undesirable radiation -- Part 1, Acupuncture & Electro-Ther.Res., Int, J., 10:255-277, 1985.
12.
OmuraY, “Bi-Digital O-Ring Test Molecular Identification and Localization Method” and its application in imaging of internal organs and malignant tumors as well as identification and localization of neurotransmitters and micro-organisms -- Part 1, Acupuncture & Electro-Ther., Int.J., 11:2;65-100, 1986.
13.
OmuraY, Practice of “Bi-Digital O-Ring Test” (in Japanese), Ido-No-Nihon-Sha, Tokyo, Japan, 1986.
14.
OmuraY, Re-evaluation of the classical acupuncture concept of meridians in oriental medicine by the new method of detecting meridian-like networks connected to internal organs using “Bi-Digital O-Ring Test”, Acupuncture & Electro-Ther.Res., Int.J., 11:219-231, 1986.
15.
PontinenPJ, Omura’s “Bi-Digital O-Ring Test” as a guide to acupuncture treatment, Acupuncture & Electro-Ther.Res., Int. J., 11:217-218, 1986.
16.
OmuraY, Electro-magnetic resonance phenomenon as a possible mechanism related to the “Bi-Digital O-Ring Test Molecular Identification and Localization Method,”, Acupuncture & Electro-Ther.Res., Int.J., 11:2;127-145, 1986.
17.
OngGOmuraY, Practical clinical application of the Bi-Digital O-Ring Test in the diagnosis, treatment, and follow-up of tuberculosis & parasitic infection, Acupuncture & Electro-Ther.Res.,Int.J., 11:243-250, 1986.
18.
PontinenPJ, Importance of Omura’s “Bi-Digital O-Ring Test” in acupuncture treatment, 5th Romanian Symposium on Acupuncture, Bucharest, October1-4, 1986.
19.
ChanJC, The application of “Bi-Digital O-Ring Test” in the diagnosis and treatment of urinary tract infection in symptomatic and asymptomatic patients, Acupuncture & Electro-Ther.Res., Int.J., 11:233-241, 1986.
20.
HidaH, Critical evaluation of Koryo Sooji Chim (Korean hand acupuncture) diagnosis by application of the Bi-Digital O-Ring Test, Acupuncture & Electro-Ther.Res., Int.J., 11:251-257, 1986.
21.
HidaK, Pressure points and treatment points — Korean hand acupuncture and “Bi-Digital O-Ring Test,”Ido-No-Nippon, The Journal of Japanese Acupuncture and Moxibustion, 4:524-530, 1986.
22.
OmuraY, Meridian-like networks of internal organs, corresponding to traditional Chinese 12 main meridians and their acupuncture points as detected by the “Bi-Digital O-Ring Test Imaging Method": search for the corresponding internal organ of western medicine for each meridian -- Part 1, Acupuncture & Electro- Ther.Res., Int.J., 12:53-70, 1987.
23.
SpenceDOmuraY, Diet. Stress, and Exercise, and their Relationship to Cardiovascular Disease, Basic and Clinical Medical Science Series of Publications by the Heart Disease Research Foundation: New York, 1987(in press)
24.
SchmidtCF, The Cerebral Circulation in Health and Disease, Charles C. Thomas: Springfield, 1950.
25.
PenfieldWRasmussenH, The Cerebral Cortex of Man: A Clinical Study of Localization of Function. Macmillan: New York, 1950.
26.
PenfieldWJasperH, Epilepsy and the Functional Anatomy of the Human Brain, Little and Brown: Boston, 1954.
27.
PenfieldW, The Excitable Cortex in Conscious Man. Liverpool University Press, 1958.
28.
PenfieldW, Speech and Perception, Rehabilitation Monograph 23: The Horowitz Lectures. The Institute of Physical Medicine and Rehabilitation, N.Y.U. Medical Center, 1963
29.
PenfieldW, The Mystery of the Mind: A Critical Study of Consciousness and the Human Brain. Princeton University Press, 1975.
30.
Cerebral Localization and Organization. SchaltenbrandGWoolseyCN, eds. Univ, of Wisconsin Press: Madison, 1964.
31.
Central Nervous System Control of the Heart. Edited by StoberTSchimrigkKGantenDG, Martinus Nijihoff Publishers: Norwell, MA, 1986.
32.
LoewyAD, Anatomic aspects of central nervous system cardiovascular regulation, pp.3-18, in, Central Nervous System Control of the Heart. StoberTSchimrigkKGantenDShermanDG, eds. Martinus Nijihoff Publishing: Norwell, MA, 1986.
33.
ReisDJRuggieroDAGranataA, Brainstem mechanisms governing the tonic and reflex control of the circulation, pp.19-36, in, Central Nervous System Control of the Heart, StoberTSchimrigkKGantenDShermanDG, eds. Martinus Nijihoff Publishing: Norwell, MA, 1986.
34.
BarnesKLAverillDBConomyJPFerrarioCM, Rostral solitary tract lesions produce vasopressin dependent hypertension in the dog, pp.37-45, in, Central Nervous System Control of the Heart. StoberTSchimrigkKGantenDShermanDG, eds. Martinus Nijihoff Publishing: Norwell, MA, 1986.
35.
OmuraY, Normal and abnormal relationship between brain circulation estimated by supraorbital temperature measurements and grasping force of the corresponding hands: their clinical application for diagnosis and evaluation of various modes of treatment -- Part 1, Acupuncture & Electro-Ther.Res,Int.J., 3:49-96, 1978.
36.
LippetHPabstR, Arterial Variations in Man: Classification and Frequency. J.F. Bergmann Verlag: Munich, 1985.
37.
NieuwenhuysRVoogdJVan HuijzenC, The Human Central Nervous System, A Synopsis and Atlas, (2nd edition)Springer-Verlag: New York, 1981.
38.
NieuwenhuysR, Chemoarchitecture of the Brain. Springer-Verlag: New York, 1985.
39.
AlexanderR, Tonic and reflex functions of medullary sympathetic cardiovascular centers, Journal of Neurophysiology, 9: 205-217, 1946.
40.
LoewyABurtonH, Nuclei of the solitary tract: efferent projections to the lower brain stem and spinal cord of the cat, J.Comp. Neur., 181: 421-450, 1978.
41.
SkinnerJEReedJC, Blockade of frontocortical brain stem pathway prevents ventricular fibrillation of ischemic heart, American Journal of Physiology, 240(Heart Circ. Physiology 9)H156-H163, 1981.
42.
CowleyAQuillenESkeltonM, Role of vasopressin in cardiovascular regulation, Fed.Proceedings, 42: 3170-3176, 1983.
43.
SoleMJVersteegDHGde KloetERHussainNLixfieldW, The identification of specific serotoninergic nuclei inhibited by cardiac vagal afferents during acute myocardial ischemia in the rat, Brain Research, 265: 55-61, 1983.
44.
YamadaKMcAllenRLoewyA, GABA antagonists applied to the ventral surface of the medulla oblongata block the baroreceptor reflex, Brain Research, 297:175-180, 1984.
45.
JacksonWKGlassmanAH, Central noradrenergic activity: a possible link between stress and cardiovascular disease, Journal of Clinical Psychiatry Monograph, 2:1, 21-24, 1984.
46.
SchwartzPJ, Stress and sudden cardiac death: the role of the autonomic nervous system, Journal of Clinical Psychiatry Monograph, 2:1, 7-13, 1984.
47.
BergercCantorCWelshJDervanPBegleyTGrantSGasparroFEdelsonR, Comparison of Synthetic Psoralen Derivatives and 8-MOP in the inhibition of lymphocyte proliferation, Ann. NY Acad. Sci., 453: 80-90, 1985.
48.
XiaYGuoXQZhangAZCaoXDLiP, Inhibitory effect of analogous electro-acupuncture on experimental arrhythmia, Acupuncture & Electro- Ther.Res.,Int.J., 10: 13-34, 1985.
