Abstract
Currently, there is an increasing interest in tissue optical clearing by the use of hyperosmotic agents due to its consequence in increasing light penetration into tissue. This has shown a great potential in enhancing the capabilities of non-invasive light-based diagnostic and imaging techniques. In this study, we introduce the oleic acid, a mono-unsaturated fatty acid, as an enhancer and investigate how its different molarities exert its effect on optical clearing of skin tissue in vitro. Experimental results from near infrared spectroscopy and mass loss measurement showed that OA01PG40, i.e. 0.1 M oleic acid in 40% propylene glycol, obtained the best clearing effect. Meanwhile, it is noticed that the molarity of oleic acid in propylene glycol is important when used in optical clearing of skin tissue in vitro.
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