Abstract
1-Amino-5-morpholino-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carbonitrile has been converted to the chloro-acetylamino derivative which was subjected to nucleophilic substitution reactions with different amines. Reaction of 1-amino-5-morpholino-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline- 2-carbonitrile with triethyl orthoformate followed by cyclisation with hydrazine yielded an aminoiminopyrimidine derivative. The latter was used as a starting material for the synthesis of a variety of fused heterocyclic compounds which include triazolopyrimidothienotetrahydroiso-quinolines.
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