Abstract
The optically pure (–)-praziquantel was synthesised using phenylethylamine as starting material in 12% overall yield. The key step was achived by a chiral auxiliary mediated Pictet–Spengler reaction.
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Diastereomeric ratio determined by 1H-NMR is 93:7, [α]D= −51.6 (C = 0.5, CH2Cl2) and yield is 88%.