A case of extremely prolonged non-progression of HIV-1 infection, characterized by 19 consecutive years of persistently undetectable viraemia (or no laboratory markers of HIV replication) is presented and discussed based on recent literature issues regarding virological and immunological outcome of the natural history of HIV-1 infection.
RodésB, ToroC, PaxinosE, Differences in disease progression in a cohort of long-term non-progressors after more than 16 years of HIV-1 infection. AIDS2004;18:1109–16
2.
SorianoV, MartínR, Del RomeroJ, Rapid and slow progression of the infection by the type 1 human immunodeficiency virus in a population of seropositive subjects in Madrid. Med Clin (Barc)1996;107:761–6
3.
SajadiMM, HerediaA, LeN, ConstantineNT, RedfieldRR. HIV-1 natural viral suppressors: control of viral replication in the absence of therapy. AIDS2007;21:517–9
4.
ChoudarySK, VrisekoopN, JansenCA, Low immune activation despite high levels of pathogenic human immunodeficiency virus type 1 results in long-term asymptomatic disease. J Virol2007;81:8838–42
5.
SchindlerM, WildumS, CasartelliN, DoriaM, KirchhoffF. Nef alleles from children with non-progressive HIV-1 infection modulate MCH-II expression more efficiently than those from rapid progressors. AIDS2007;21:1103–7
6.
PancréV, DelhemN, YazdanpanahY, Presence of HIV-1 Nef specific CD4 T-cell response is associated with non-progression in HIV-1 infection. Vaccine2007;25:5927–37
7.
GrayL, ChurchillMJ, SterjovskiJ, Phenotype and envelope gene diversity of nef-deleted HIV-1 isolated from long-term survivors infected from a single source. Virol J2007;4:75
8.
ChurchillMJ, ChiavaroliL, WesselinghSL, GorryPR. Persistence of attenuated HIV-1 rev alleles in an epidemiologically linked cohort of long-term survivors infected with nef-deleted virus. Retrovirology2007;4:43
9.
MorsicaG, BagaglioS, GhezziS, Hepatitis C virus (HCV) coinfection in a cohort of HIV positive long-term non-progressors: possible protective effect of infecting HCV genotype on HIV disease progression. J Clin Virol2007;39:82–6
