Sage Journals: Discover world-class research

Abstract

Objectives

To compare the effect of delaying surgery on clinical outcome in patients with chronic sciatica secondary to lumbar disc herniation.

Methods

Patients with sciatica lasting 4–12 months and lumbar disc herniation at the L4–L5 or L5–S1 level were randomized to undergo microdiscectomy (early surgery) or to receive 6 months of nonoperative treatment followed by surgery if needed (delayed surgery). Outcomes were leg pain, Oswestry Disability Index score (ODI), back pain, SF–36 physical component (PCS) and mental component (MCS) summary scores, employment, and satisfaction measured preoperatively and at 6 weeks, 3 months, 6 months, and 1 year after surgery.

Results

Of the 64 patients in the early surgery group, 56 underwent microdiscectomy an average of 3 ± 2 weeks after enrollment. Of the 64 patients randomized to nonoperative care, 22 patients underwent delayed surgery an average of 53 ± 24 weeks after enrollment. The early surgery group experienced less leg pain than the delayed surgery group, which was the primary outcome, at 6 months after surgery (early surgery 2.8 ± .4 vs delayed surgery 4.8 ± .7; difference, 2.0; 95% confidence interval, .5–3.5). The overall estimated mean difference between groups significantly favored early surgery for leg pain, ODI, SF36-PCS, and back pain. The adverse event rate was similar between groups.

Conclusions

Patients presenting with chronic sciatica treated with delayed surgery after prolonging standardized non-operative care have inferior outcomes compared to those that undergo expedited surgery.

Keywords

disc herniation lumbar discectomy sciatica nonoperative

Introduction

Surgery to treat acute sciatica secondary to lumbar disc herniation is recognized to provide a faster recovery compared to prolonged conservative care followed by delayed surgery if needed, but outcomes become equal by 1 year.¹ In contrast, microdiscectomy for chronic sciatica from lumbar disc herniations provides superior and sustained benefit over conservative care.² In the case of acute sciatica, delayed surgery did not appear to negatively affect the ultimate outcome.^1,3 This may not be the case for more chronic disc herniations.^4–7

In our previously published randomized controlled trial (RCT) comparing microdiscectomy to standardized conservative care for sciatica from lumbar disc herniation lasting greater than 4 months the cross-over of non-operative patients to surgery before 6 months after enrollment was minimized by design.² This design therefore created a cohort of patients that received early surgery and a cohort of patients that received non-operative care followed by delayed surgery. In the current study, we present a secondary analysis of patients that underwent early surgery compared to those that received non-operative care followed by delayed surgery (waiting 6 months or longer) for chronic sciatica secondary to a lumbar disc herniation. The primary aim of the current study was to examine the hypothesis of whether patients report less leg pain at 6 months after early surgery as compared to those that received delayed surgery.

Methods

Eligibility and Randomization

The trial was approved by our institutional research ethics board and is registered (ClinicalTrials.gov number, NCT01335646). All participants provided written informed consent before enrollment in the study.

Consecutive patients referred to the London Health Science Centre, London Canada, from February 2010 through August 2016 were screened for this study by a research coordinator by telephone and by a study physician at an initial screening visit. Inclusion criteria were age 18–60 years, unilateral radiculopathy lasting 4–12 months, and posterolateral disc herniation at L4–5 or L5–S1 on the appropriate side with compression of the corresponding traversing nerve root confirmed on magnetic resonance imaging. Patients were excluded if they had radiculopathy secondary to the following at the involved level: herniation within the foramen or far lateral disc, spinal stenosis, deformity (i.e., Scoliosis >10°), or previous lumbar spine surgery. Patients were also excluded if they had epidural spinal injection or exercised-based physiotherapy for the presenting episode of sciatica. Patients were randomly assigned in a 1:1 allocation to early surgery or nonoperative care followed by surgery if needed (delayed surgery) by a computer-generated random number list using a permuted block design. Patients were stratified according to work’s compensation status.^8,9

Trial Interventions

Early Surgery

An open or minimal-access approach was used for microdiscectomy with loupe or microscope assistance/magnification. All surgeries were performed as day surgery or 1-night stay.

Delayed Surgery

Patients in the delayed surgery group received initial nonoperative care while waiting on the surgical waiting list. Non-operative treatment included patient education, oral analgesics (non-steroidal anti-inflammatory drugs, acetaminophen, or acetaminophen with codeine/oxycodone/tramadol, and amitriptyline/gabapentin/pregabalin as tolerated), an active exercised-based physiotherapy program, and up to 3 epidural steroid injections/therapeutic nerve root block. The standard wait on the waiting list was greater than 6 months. Therefore, patients with persistent symptoms underwent surgery following this standard wait.

Outcome Measures

Outcomes were assessed preoperatively and at 6 weeks, 3 months, 6 months, and 1 year after surgery. The primary outcome was the visual analog scale (VAS) for intensity of leg pain (range 0–10: 0 = no pain, 10 worst pain) measured at 6 months following surgery. Secondary measures which were measured at 3 months, 6 months, and 1 year were the VAS intensity for leg pain, VAS for intensity of low back pain, the Oswestry Disability Index (ODI),¹⁰ the Medical Outcomes Study 36-item Short-Form General Health Survey (SF36) physical component summary (PCS) score and mental component summary score,^11,12 employment status, and satisfaction with treatment.¹³ Adverse events related to surgical treatment were documented for up to 1 year after surgery.

Statistical Analysis

The sample size was determined for the parent RCT and was not calculated specifically for the purpose of this analysis. For the parent RCT, 15 patients per group were determined to be required to detect a minimal important difference of 2 points in leg pain intensity at 6 months after surgery between the cohort treated with early surgery and that treated with delayed surgery. We assumed a standard deviation of 1.9 points, a statistical power of .80, and a 2-tailed significance level of .05. All analysis was performed using SPSS software, version 26 (SPSS Inc, Chicago, IL, USA). Significance was set at a two-sided alpha level of 5% with no adjustments made for multiple comparisons.

Differences at baseline were examined with the use of a Students t-test, Mann U Whitney test, chi-square test, or Fisher’s exact test as appropriate. Participants with missing data at the 12-month time point were compared to those who participated in all visits.

Linear mixed effects models were used to compare continuous outcomes between groups, using a random effect for participant and a compound symmetry assumption on the correlation of residuals. Treatment (early surgery vs delayed surgery), time (categorical), treatment × time interaction, baseline score, and covariates associated with baseline and missing values including sex and smoking status were included in the model. The estimated marginal difference between groups taking all time points into consideration (overall treatment effect), and the adjusted mean differences between groups and the 95% confidence intervals (CIs) at each predetermined time point were compared. For binary outcomes, generalized estimating equations were used to fit repeated measures. Post-operative follow-up time points were based on the time of surgery with the baseline assessment taken at enrollment for the early surgery group and immediately prior to surgery for the delayed surgery group.

Results

A total of 790 patients were screened for eligibility by telephone interview (Figure 1). Of these patients, 128 were enrolled with 64 randomized to early surgery and 64 randomized to initial non-operative treatment with delayed surgery if needed. The majority of the 622 patients excluded had either improved (46%) or declined to participate (16%).

Figure 1.

Flow diagram showing early surgery and delayed surgery cohorts, and follow-up. patients were randomized to receive 6 months of nonoperative treatment followed by surgery if needed (delayed surgery). ^bcumulative over time.

Of the 64 patients in the early surgery group, 56 received surgical treatment per protocol. Seven patients canceled their surgery because they felt their symptoms had improved. One patient developed a cardiac arrhythmia during the pre-operative work-up and was not able to undergo surgical treatment. Out of the 64 patients randomized to initial non-operative care followed by surgery if needed, 2 patients sought treatment at another facility and received early surgical treatment within 8 weeks after enrollment. Of the remaining 62 patients, 22 patients graduated to delayed surgery following 6 months of non-operative care for the initial presenting radiculopathy. The follow-up rate ranged from 87% at the 6-week visit to 73% at the 12-month visit with losses due to missed visits or withdrawals (Figure 1). Patients that missed their 12-month follow-up appointment were more likely to smoke (71% vs 19%, P = .004) and were more likely to be male (49% vs 88%, P = .005) compared to patients that did not miss this appointment.

The demographic and clinical characteristics were similar between the 2 groups except for time from enrollment to surgery, which was expected to be longer in the delayed surgery group (53 ± 24 weeks vs 3 ± 2 weeks, P < .001; Table 1).

Table 1.

Demographic and Clinical Characteristics of Patients at Baseline.

Variable	Delayed surgery^a (N = 22)	Early Surgery (N = 56)	P Value
Age, years, mean ± SD	34.5 ± 11.2	37.7 ± 8.0	.167
Body mass index, kg/m2, mean ± SD	26.5 ± 5.7	27.6 ± 5.9	.450
Women, no. (%)	7 (31.8)	26 (46.4)	.311
Worker’s compensation, no. (%)	1 (4.5)	4 (7.1)	1.000
Smoking status, no. (%)
Current smoker	9 (40.9)	21 (37.5)	.801
No longer/never	13 (59.1)	35 (62.5)	.801
Employment status, no. (%)
Not employed (related to back pain)	3 (13.6)	7 (12.5)	.713
Not employed (unrelated to back pain)	2 (9.1)	5 (8.9)
Employed	16 (72.7)	37 (66.1)
Student	1 (4.5)	2 (3.6)
Disability	0 (.0)	5 (8.9)
Income, no. (%)
≤50 000	14/20 (70.0)	30/49 (61.2)	.587
>50 000	6/20 (30.0)	19/49 (38.8)	.587
Duration time to surgery, weeks, mean ± SD	53 ± 24	3 ± 2	<.001
Primary symptom, no. (%)
Leg pain	19 (86.4)	43 (76.8)	.528
Back pain	1 (4.5)	2 (3.6)
Both	2 (9.1)	11 (19.6)
Any neurologic deficit, no. (%)^b
Reflexes, asymmetrical decrease	7 (31.8)	32 (57.1)	.077
Sensory, asymmetrical decrease	12 (54.5)	36 (64.3)	.449
Motor, asymmetric weakness	6 (27.3)	18 (32.1)	.448
Herniation type, no. (%)^b
Protruding	3 (13.6)	12 (21.4)	.536
Extruded	17 (77.3)	41 (73.2)	.781
Sequestered	3 (13.6)	5 (8.9)	.680
Herniation level, no. (%)
L4–5	7 (31.8)	15 (26.8)	.781
L5–S1	15 (68.2)	41 (73.2)	.781
Radiculopathy, no. (%)
L5	8 (36.4)	15 (26.8)	.420
S1	14 (63.6)	41 (73.2)	.420
Radiculopathy, no. (%)
Right	11 (50.0)	29 (51.8)	1.000
Left	11 (50.0)	27 (48.2)	1.000
Medication, n (%)^b
Non-steroidal anti-inflammatory drug	10 (45.5)	25 (44.6)	1.000
Cyclooxygenase-2 inhibitor	2 (9.1)	7 (12.5)	1.000
Narcotics	13 (59.1)	29 (51.8)	.620
Muscle relaxant	2 (9.1)	0 (.0)	.077
Neuromodulator	8 (36.4)	16 (28.6)	.588
Antidepressant	2 (9.1)	16 (28.6)	.079
Other	1 (4.5)	13 (23.2)	.097
None	3 (13.6)	7 (12.5)	1.000
Intensity of leg pain^c, mean (SD	7.6 ± 1.9	7.8 ± 1.9	.716
Oswestry Disability Index^d, mean (SD)	49.1 ± 17.5	51.2 ± 15.2	.597
SF-36 physical component score^e, mean (SD)	27.0 ± 6.5	25.6 ± 7.2	.432
SF-36 mental component score^e, mean (SD	33.7 ± 11.7	35.3 ± 13.3	.626
Intensity of back pain score^c, mean (SD)	6.9 ± 2.4	6.7 ± 2.6	.763

^aThe delayed surgery group differs from the parent trial analysis in that it excludes the 2 patients that had early surgery and includes 2 patients that crossed-over 2 years after enrollment.² Varying denominators indicate missing data for patients in some categories.

^bParticipants could have more than 1 medication, herniation type, or neurologic symptom.

^cIntensity of leg and back pain scores range from 0 to 10, with lower scores indicating less severe symptoms.

^dIn the Oswestry Disability Index, the range of scores is 1–100, with high scores indicating worse disability and pain.

^eSF-36 mean summary scores are based on normative data and have a mean (SD, 50), with higher scores indicating a better quality of life.

Analysis of the primary outcome revealed that the early surgery group experienced less leg pain than the delayed surgery group at 6 months after surgery (early surgery 2.8 ± .4 vs delayed surgery 4.8 ± .7; difference, 2.0; 95% CI, .5–3.5; Table 2; Fig. 2). A similar reduction in leg pain was found at 3 months and 1 year in favor of early surgery (Table 2). At all time-points, SF36-PCS scores were statistically and clinically significant in favor of early surgery (Table 2; Fig. 2). At 3 months, the early surgery group experienced better mental functioning (difference, –7.1; 95% CI, –14.0, –.2), and less back pain than the delayed surgery group (difference, 1.6; 95% CI, .3, 3.0; Table 2). ODI score at 6 months was 24.9 ± 2.7 in the early surgery group and 36.6 ± 4.2 in the delayed surgery group (difference, 11.8; 95% CI, 2.1-21.5; Table 2). A similar proportion of patients were satisfied with treatment and were employed in each group; Table 2; Fig. 2). The overall mean treatment effect significantly favored early surgery for intensity of leg pain, ODI, SF36-PCS, and intensity of back pain (Figure 2).

Table 2.

Adjusted Mean or Percentage and Difference for Primary and Secondary Outcomes.

Outcome Measure	Early Surgery		Delayed Surgery		Difference (95% CI)
	n	Value	n	Value
Primary Outcome
Intensity of leg pain^a
6 months	42	2.8 ± .4	18	4.8 ± .7	2.0 (.5, 3.5)
Secondary outcomes^b
Intensity of leg pain^a
3 months	43	2.8 ± .4	17	5.1 ± .7	2.3 (.8, 3.8)
12 months	45	2.7 ± .4	16	5.3 ± .7	2.6 (1.1, 4.1)
Oswestry Disability Index^c
3 months	44	27.2 ± 2.6	17	36.0 ± 4.2	8.8 (−.8, 18.6)
6 months	42	24.9 ± 2.7	18	36.6 ± 4.2	11.8 (2.1, 21.5)
12 months	45	25.2 ± 2.6	16	33.6 ± 4.3	8.3 (−1.4, 18.1)
SF36 physical component score^d
3 months	43	38.7 ± 1.4	17	31.6 ± 2.2	−7.2 (−12.3, −2.0)
6 months	42	40.2 ± 1.4	16	31.7 ± 2.3	−8.3 (−13.7, −3.0)
12 months	45	41.9 ± 1.4	16	33.5 ± 2.3	−8.4 (−13.6, −3.2)
SF36 mental component score^d
3 months	43	46.4 ± 1.9	17	39.3 ± 3.0	−7.1 (−14.0, −.2)
6 months	42	47.1 ± 1.9	16	42.2 ± 3.1	−4.9 (−11.9, 2.2)
12 months	45	46.8 ± 1.9	16	43.9 ± 3.0	−2.9 (−9.9, 4.0)
Intensity of back pain^a
3 months	43	3.6 ± .4	17	5.2 ± .6	1.6 (.3, 3.0)
6 months	42	3.3 ± .4	18	4.5 ± .6	1.2 (−.2, 2.6)
12 months	45	3.5 ± .4	16	4.7 ± .6	1.2 (−.2, 2.6)
Satisfied with treatment (%)
3 months	42	91 ± 5	17	88 ± 8	−2 (−20, 15)
6 months	42	91 ± 4	17	67 ± 12	−24 (−48, 1)
12 months	45	91 ± 4	15	72 ± 11	−19 (−42, 4)
Employed (%)
3 months	44	66 ± 9	16	68 ± 14	2 (−29, 32)
6 months	42	72 ± 8	18	51 ± 12	−21 (−49, 7)
12 months	42	72 ± 8	15	41 ± 9	−31 (−55, 7)

Values are adjusted mean or percentage (SE). Values are adjusted for baseline score, sex, and smoking status. CI denotes confidence interval.

^aIntensity and frequency of leg and back pain scores range from 0 to 10, with lower scores indicating less severe symptoms.

^bSecondary outcomes are not adjusted for multiple comparisons.

^cIn the Oswestry Disability Index, the range of scores is 1–100, with high scores indicating worse disability and pain.

^dSF-36 physical component and mental component mean summary scores, with higher scores indicating better quality of life.

Figure 2.

Time course of patient-rated clinical outcomes. Scores over time are shown for (A) Leg-pain intensity (primary outcome), (B) Oswestry Disability Index, (C) Back-pain intensity, (D) SF-36 physical component summary score, (E) SF-36 mental component summary score, (F) satisfaction with treatment, and (G) the employment status. At 0 months, the data points represent the observed means. The data points on the plot lines represent the estimated means or proportions from mixed effects longitudinal analysis adjusted for baseline score and covariates associates with baseline and missing values, with error bars denoting 95% confidence interval (CI). The overall mean (taking all time points into consideration) of each group, standard error, difference between groups, and the corresponding 95% CI are indicated. Intensity of leg and back pain scores range from 0 to 10, with lower scores indicating less severe symptoms. In the Oswestry Disability Index, the range of scores is 1–100, with high scores indicating worse disability and pain. In the SF-36 physical component and mental component summary scores, higher scores indicate better quality of life.

Five patients in the delayed surgery group and 4 in the early surgery group registered at least 1 adverse event (Table 3). This included 1 revision surgery for a recurrent disc herniation for a patient in the early surgery group.

Table 3.

Adverse Events Related to Surgery.

Adverse Event Occurring within 1 year of Surgery	Early Surgery (N = 56)	Delayed Surgery^a (N = 22)	P Value
Patients with at least 1 event, no. of patients (%)	4 (7)	5 (23)	.108
Total adverse events, no. of events (event rate)	5 (.09)	6 (.27)	.070
Adverse events, no
Dural tear	0	1
Superficial wound infection	2	1
Nerve-root injury	0	1
Postoperative adjacent level condition	0	1
New onset postoperative neuropathic pain	1	2
Recurrent herniation following surgery^b, no further surgery required	1	0
Recurrent herniation following surgery^b, revision surgery required	1	0

^aThe delayed surgery group differs from the parent trial analysis in that it excludes the 2 patients that had early surgery and includes 2 patients that crossed-over 2 years after enrollment.²

^bRecurrent herniation refers to a herniation at the same side and level as the primary herniation.

Discussion

This study demonstrates that patients who undergo delayed surgery for a chronic disc herniation following failure of 6 months of standardized non-operative care, had overall poorer patient rated-outcome measures than those that received early surgery. This finding has important implications for the shared decision-making process in the treatment of lumbar disc herniations. Not only does prolonged non-operative care have inferior results compared to early discectomy² (as found in the original RCT on which this analysis is based) but this follow-up study further demonstrated that delayed surgery resulted in inferior outcomes. Therefore, the consideration to “try” non-operative care for a patient presenting with chronic sciatica with the expectation of defaulting to surgery should that trial fail, will potentially increase the risk of a lesser improvement compared to early surgery. It is important to note that chronic sciatica was defined as lasting more than 4 months and excluded patients that presented with more than 12 months of sciatic when generalizing our study’s findings.

Our findings are in contrast to those for acute sciatica from a lumbar disc herniation. Peul et al compared early vs prolonged conservative care followed by (delayed) surgery for acute sciatica, defined by symptoms of 6–12 weeks, and found that the results of delayed surgery were similar at 1 year follow-up to early surgery.^1,3 However, beside the difference in chronicity of sciatica between the 2 studies, the length of the delay to surgery was also shorter, averaging 14.6 weeks as compared to our average wait of 53 weeks. Our RCT was designed within the constraints of the Canadian health care system, which provided for a minimum surgical wait in the delayed group of 6 months. This reflects the normal wait-time to have a surgical consult and receive surgery. Similar waits in other public systems are likely, and given this prolonged wait, the potential negative consequences of deferring the decision to operate needs to be carefully considered. Furthermore, enhanced access to microdiscectomy within these medical systems should be considered recognizing the potential morbidity in delayed treatment.

Other studies have found duration of sciatica to negatively correlates with post-discectomy outcomes. Nygaard et al. found that after 8 months of leg pain, there may be increased risk of a poor surgical outcome.⁴ Rihn et al. performed an as-treat analysis of the Spine Pain and Outcomes Research Trial to demonstrate that symptom duration greater than 6 months led to inferior outcomes.⁷ This study differed from ours with their inclusion of patients with a more acute sciatica presentation and that patient preference was a key deciding factor in the decision to operate as the analysis combined the observational arm and randomization arm (which had substantial cross-over due to patient preference). However, Quon et al, showed that patients in a system-imposed wait, as opposed to patient preference, of more than 12 weeks had a comparatively higher chance of experience a worse outcome then patients waiting less than 12 weeks.⁵ They also found that self-reported symptom duration negatively correlated with surgical outcome at 6 months. This study, however, also combined patients with both acute and chronic sciatica and defined outcome based on the patient’s predominant pain symptom which could be either leg or back pain. Our study supports the findings of these previous trials in that the results are of higher quality evidence and represent a relatively homogenous population of patients with chronic sciatica single payer public health system from a universal public health system.

Our finding that patients undergoing delayed surgery had worse outcomes compared to those undergoing early surgery is likely due to the delay in treatment and the potential centralization of chronic pain. Once such explanation may be due to sensitization of the central nervous system elicited by a prolonged inflammatory and immune mediated response.^14-16 Ongoing nociceptive sensitization in animal and in vitro human models is thought to evoke changes in plasticity and remodeling of spinal and supraspinal pain pathways that maintain chronic pain even after mechanical compression of the nerve is relieved and the inflammation has resolved.^14-16

A number of potential limitations exist in this study. Firstly, this was a secondary analysis of a randomized controlled study, for which the primary comparison was operative vs non-operative care and not specifically delayed surgery. From an ethical perspective, patients randomized to delayed surgery required non-operative treatment while awaiting surgery. As expected, patients did improve with non-operative care and approximately only a third of patient’s ultimately chose to undergo delayed surgery following their trial of standardized non-operative care. There was no difference between these surgical groups in baseline demographics or clinical characteristics. However, as this is a secondary analysis there may be confounding variables that were not accounted for in the trial design. Another caveat is that selection bias may exist at the time of enrollment, as both the participating surgeons and patients may be less inclined to pursue non-operative care if they suffer from severe sciatica. However, only a small percentage of patients declined participation at the time of recruitment; suggesting our study population is well representative of the population referred in a universal health care system with chronic sciatic from lumbar disc herniation. Although, this was a RCT by design, only the accessors, but not the surgeons, physicians, therapists, or patients were blinded to the treatment. Further, secondary outcomes were not adjusted for multiple comparisons and thus these findings should be interpreted with caution. Our lost to follow-up rate was initially good at early follow-up periods but declined to 73% by the 1-year time point. The baseline characteristics of patients with missed visits at this time point were similar to the rest of the cohort except these patients were more likely to be male and smoke. Finally, we included only patients with an L4–5 and L5–S1 disc herniation which may limit the findings generalizability to a patient with an upper lumbar disc herniation.^17,18

In conclusion, this study found that patients treated with delayed surgery presenting with chronic sciatica from a lumbar disc herniation have inferior outcomes compared to those that undergo expedited surgery. For patient and surgeon preference, this has important implications in the decision to pursue non-operative vs operative care. Furthermore, it demonstrates the potentially deleterious effect a system-imposed wait, such as that experienced in publicly funded health care system, could have in outcome following lumbar discectomy.

Footnotes

Declaration of Conflicting Interests

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Funding

The author(s) received no financial support for the research, authorship, and/or publication of this article: The authors disclose receipt of the following financial support for the research, authorship, and/or publication of this article: The work was supported by the Physicians’ Services Incorporated Foundation.

ORCID iDs

Andrew Kanawati

Keith Sequeira

Jim Watson

Jennifer C. Urquhart

References

Peul

van Houwelingen

van den Hout

Brand

Eekhof

JAH

Tans

JTJ

, et al. Surgery versus prolonged conservative treatment for sciatica. N Engl J Med. 2007;356(22):2245-2256.

Bailey

Rasoulinejad

Taylor

Sequeira

Miller

Watson

, et al. Surgery versus conservative care for persistent sciatica lasting 4 to 12 months. N Engl J Med. 2020;382(12):1093-1102.

Peul

Hout

WBvd

Brand

Thomeer

RTWM

Koes

Leiden-The Hague Spine Intervention Prognostic Study Group . Prolonged conservative care versus early surgery in patients with sciatica caused by lumbar disc herniation: Two year results of a randomised controlled trial. BMJ. 2008;336(7657):1355-1358.

Nygaard

Kloster

Solberg

. Duration of leg pain as a predictor of outcome after surgery for lumbar disc herniation: A prospective cohort study with 1-year follow up. J Neurosurg. 2000;92(2 suppl l):131-134.

Quon

Sobolev

Levy

Fisher

Bishop

Kopec

, et al. The effect of waiting time on pain intensity after elective surgical lumbar discectomy. Spine J. 2013;13(12):1736-1748.

LCL

Sell

. Predictive value of the duration of sciatica for lumbar discectomy. A prospective cohort study. J Bone Joint Surg Br. 2004;86(4):546-549.

Rihn

Hilibrand

Radcliff

Kurd

Lurie

Blood

, et al. Duration of symptoms resulting from lumbar disc herniation: Effect on treatment outcomes: Analysis of the Spine Patient Outcomes Research Trial (SPORT). J Bone Joint Surg. 2011;93(20):1906-1914.

Atlas

Tosteson

Hanscom

Blood

Pransky

Abdu

, et al. What is different about workers’ compensation patients? Socioeconomic predictors of baseline disability status among patients with lumbar radiculopathy. Spine (Phila Pa 1976). 2007;32(18):2019-2026.

Atlas

Tosteson

Blood

Skinner

Pransky

Weinstein

. The impact of workers’ compensation on outcomes of surgical and nonoperative therapy for patients with a lumbar disc herniation: SPORT. Spine (Phila Pa 1976). 2010;35(1):89-97.

10.

Fairbank

Pynsent

. The oswestry disability index. Spine (Phila Pa 1976). 2000;25(22):2940-2952; discussion 2952.

11.

Grevitt

Khazim

Webb

Mulholland

Shepperd

. The short form-36 health survey questionnaire in spine surgery. J Bone Joint Surg Br. 1997;79(1):48-52.

12.

Hopman

Towheed

Anastassiades

Tenenhouse

Poliquin

Berger

, et al. Canadian normative data for the SF-36 health survey. Canadian Multicentre Osteoporosis Study Research Group. CMAJ. 2000;163(3):265-271.

13.

Hudak

Wright

. The characteristics of patient satisfaction measures. Spine (Phila Pa 1976). 2000;25(24):3167-3177.

14.

Gosselin

R-D

Suter

R-R

Decosterd

. Glial cells and chronic pain. Neuroscientist. 2010;16(5):519-531.

15.

Dower

Davies

Ghahreman

. Pathologic basis of lumbar radicular pain. World Neurosurg. 2019;128:11-121.

16.

Geiss

Sobottke

Delank

Eysel

. Plasmacytoid dendritic cells and memory T cells infiltrate true sequestrations stronger than subligamentous sequestrations: Evidence from flow cytometric analysis of disc infiltrates. Eur Spine J. 2016;25(5):1417-1427.

17.

Lurie

Faucett

Hanscom

Tosteson

Ball

Abdu

, et al. Lumbar discectomy outcomes vary by herniation level in the Spine Patient Outcomes Research Trial. J Bone Joint Surg Am. 2008;90(9):1811-1819.

18.

Weinstein

Tosteson

Lurie

Tosteson

ANA

Hanscom

Skinner

, et al. Surgical vs nonoperative treatment for lumbar disk herniation: The Spine Patient Outcomes Research Trial (SPORT): A randomized trial. JAMA. 2006;296(20):2441-2450.

Early Versus Delayed Microdiscectomy for Chronic Sciatica Lasting 4–12 Months Secondary to Lumbar Disc Herniation: A Secondary Analysis of a Randomized Controlled Trial

Abstract

Objectives

Methods

Results

Conclusions

Keywords

Introduction

Methods

Eligibility and Randomization

Trial Interventions

Early Surgery

Delayed Surgery

Outcome Measures

Statistical Analysis

Results

Discussion

Footnotes

Declaration of Conflicting Interests

Funding

ORCID iDs

References