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Abstract

Acute appendicitis is among the commonest surgical emergencies seen in an acute setting. Individuals living with the Human Immunodeficiency Virus (HIV) and/or the Acquired Immunodeficiency Syndrome (AIDS) have an increased risk of encountering complications with acute appendicitis. We conducted a literature search using the words appendicitis and HIV in google scholar, Medline, Scopus and PubMed. The search also extended to cover HIV presented with acute appendicitis, their outcome during and following the management of acute appendicitis. Several studies showed that HIV is associated with a higher rate of acute appendicitis than the general population. HIV can directly affect the appendix, through opportunistic infections, immune reconstitution inflammatory syndrome associated with start of antiretroviral medication. High index of suspicion is needed to exclude conditions that mimic acute appendicitis (abdominal tuberculosis, pyelonephritis, cytomegalovirus, cryptosporidium, pneumococcus, Amoebic appendicitis and pill impaction). The clinical presentation may not be typical of acute appendicitis and can be associated with low white cell count and variable fever. The Alvarado score for predicting acute appendicitis can be used and more research is needed to establish cut-off point value. Computed tomography scan and ultrasound are widely used in clinical diagnosis. Importantly, acute appendicitis with HIV/AIDS can be associated with high rate of post-surgical complications like infections, delay of healing, perforation, peritonitis, intra-abdominal abscess and longer hospital stay. HIV/AIDS with acute appendicitis is complex condition. Therefore, we conclude that patients with known HIV and acute appendicitis should also be managed in close liaison with HIV physicians during, before and after surgical treatment.

Keywords

Appendicitis HIV emergency surgery

Epidemiology

In the general population, the prevalence of acute appendicitis (AA) is 0.1%, while with HIV/AIDS, the prevalence ranging from 0.6% to 3.6%, and this is estimated to be 8% absolute increase in the risk. Thus, AA occurs at higher rates in people living with HIV (PLWHIV).¹ Therefore, the increase in the prevalence of HIV/AIDS in developing countries was also associated with an increase in the incidence of AA. It is worth mentioning that HIV/AIDS patients are associated with a 15-fold higher risk of acute perforated appendicitis than the general population.² Despite the fact that surgical treatment of AA was associated with decline in mortality from 26% to less than 0.2 per 100,000 population currently,³ complications associated with surgery and presence of comorbidities can lead to an increase mortality up to 5%.

AA is one of the most common surgical emergencies in the world attributed to the inflammation of appendix. This inflammation was thought to occur in case of appendix obstruction (infection, calculi, fecaliths, lymphoid hyperplasia, infection and presence of tumours). The obstructed appendix can lead to bacterial overgrowth which in turn can lead to a disseminated sepsis. Early AA predominantly has aerobic organisms while mixed flora is more common in late appendicitis.⁴ Escherichia Coli, Bacteroides Fragilis, Peptostreptococcus and Pseudomonas species are linked with gangrenous and perforated appendicitis.⁵ This research project was conducted as a review article. The authors searched on the literature using the following databases: PubMed, Medline, Scopus and Google scholar. These databases were searched using the keywords HIV/AIDS, appendicitis, presentation of appendicitis and perioperative care in HIV individuals. The authors searched also using combination of the following terms ((HIV) AND (AIDS) AND (appendicitis)) OR ((perioperative) AND (emergency) AND (immunocompromised)). The search was based on studies published in English language from 1981 to 2020, the abstracts and the articles were then screened. Articles were scanned and read; further relevant references in the reference lists are also included. This is still a new area for research and exploration; therefore, we have also included experience gained from observations in case reports.

HIV and appendicitis

HIV can increase the risk of AA in different ways. For instance, the HIV virus can directly target the appendix.⁶ In other situations, the AA can be associated with opportunistic infections like Kaposi’s sarcoma, cytomegalovirus, Mycobacterium sp, Cryptosporidiosis and Salmonella typhi infection.⁷ Importantly, the association of AA with HIV/AIDS is likely to occur on average older individuals than the general population. This likely attributed to the fact that PLWHIV are living longer with administration of antiretroviral medication. Therefore, surgeons are recommended to have high index of suspicion, as some patients may present with features not consistent with typical diagnosis of AA (less frequency of fever and a leucocytosis). For example, Duhamel et al.⁸ showed that AA in an HIV-infected subject can mimic acute pyelonephritis secondary to obstruction. Perioperative care is essential and attention should be paid to the fact that these patients are at risk of developing complications like infection, delay in wound healing, perforation, intra-abdominal abscess, peritonitis and prolonged hospital stay, and ultimately all these complication may lead to an increase in mortality.⁹–¹¹

Another factor that can be associated with AA is immune reconstitution inflammatory syndrome (IRIS). This syndrome is associated with initiation of combined antiretroviral therapy (cART), which initiates a pathological inflammatory response to a previous infection resulting in appendicitis.^10,11 Different mechanisms were also suggested to have role in the AA such as strong interferon response in the appendix may in part endorse a viral aetiology for the inflammation. Such observation can be also endorsed by the fact that the appendix is also part of the gut lymphoid tissues and this may further explain the involvement of the mucosal B and T cells and the replication of the HIV virus in the appendix.^10,11 The role of immune status and CD4 count is also linked with AA. For example, Bedada et al.¹¹ showed that high postoperative complications and mortality in HIV patients with AA can be associated with a CD4 count <200. León-Ballesteros et al. showed that AA in PLWHIV can be associated with low prevalence of leukocytosis; however, their study showed that presence of both diabetes and HIV can be associated with high rate of surgical complications and an increase in hospital stay.¹² Therefore, early involvement of HIV physician in the management of these patients is highly recommended.

Importantly, it was shown that in a retrospective study in South Africa,¹⁰ a perforated appendicitis was more reported in HIV-positive patients and this explains the need for more laparotomy in this group. In this study, it was shown that only in HIV patients, granulomatous inflammation was found.¹⁰ In other studies, no difference was seen in the complication rate, length of hospital stays, and mortality between HIV-positive and HIV-negative patients.^11,13 In one case study, pill impaction was found in appendiceal orifice with HIV patient.¹⁴ In summary, it is possible that HIV can influence the appendix in different ways: (1) HIV virus directly affects the appendix, (2) opportunistic infections, (3) IRIS and (4) high levels of perioperative complications.

In addition to usual organisms, some unusual pathogens can precipitate appendicitis in HIV-infected patients. The causative agents including mycobacterium, cytomegalovirus, cryptosporidium, pneumococcus, Amoebic appendicitis, Pill Impaction and IRIS have been reported as AA in HIV patients.^6,13
–15 There are different conditions in HIV patients which can present as abdominal pain or right iliac fossa pain. For instance, disseminated histoplasmosis and Kaposi’s Sarcoma can present as AA.^16
–20

Clinical presentation

Clinical presentation can be variable but abdominal pain is the most common symptom with appendicitis.^21,22 Other common clinical symptoms were right lower quadrant abdominal pain, nausea and vomiting. Some have atypical/nonspecific symptoms including indigestion, flatulence, diarrhoea and generalized malaise, and symptoms are mainly dependant on location of the appendix.

Investigations

Diagnosis of AA is based on clinical assessment, laboratory findings (C-reactive protein (CRP), white blood cell (WBC), but WBC is not always a reliable indicator such as in pregnancy) and imaging modalities like ultrasound and computed tomography (CT). Magnetic resonance imaging (MRI) is not widely used in the diagnosis of AA but can be used in further assessment of acute abdomen and pelvic pain.^21,22

Role of the scoring system

The Alvarado score was widely used in establishing the diagnosis of the AA. The clinical score system has six clinical items and two laboratory measurements with a total 10 points (temperature, rebound tenderness, anorexia, nausea and vomiting, migration of pain to the right quadrant, and tow lab measurements are Leukocytosis > 10,000 and Leukocyte Left Shift).²³ In systematic review by Ohle, the cut-point of Alvarado score of 5 in general population without HIV was a good score to determine patients in need to be admitted to the hospital. Importantly, the score performed poorly when using the cut-point of 7 as point for progression to surgery.²³ Sobnach et al.²⁴ showed that cut-point of 8 can be used accurately to predict the diagnosis of appendicitis in HIV patients. However, further research is needed to assess the role of Alvarado score in the diagnosis of AA in HIV.

The diagnosis can be established from the history, clinical examination and simple blood investigations like CRP and WBCs. In case of doubt about the diagnosis, it is advisable to perform imaging studies such as abdominal ultrasound or CT.²⁵ The accuracy of ultrasound is estimated to be between 71% and 97%, while the accuracy rate of CT scanning is between 93% and 98%.²⁶ These image modalities were also used in HIV patients for the diagnosis of appendicitis (Figure 1).

Figure 1.

The steps in the management of acute appendicitis in individuals living with HIV.

Surgical management

HIV is a condition associated with low immunity; therefore, we have provided full summary of information about preoperative and postoperative care for PLWHIV in Table 1.

Table 1.

Summary of necessary information about preoperative and postoperative care for individuals with HIV.

Preoperative care	Postoperative care
1. Favourable outcome of surgery in HIV individuals irrespective of duration and type of operation	1. HIV patients are more prone for hyper coagulation, so consider early mobilization and DVT prophylaxis
2. Use of plasma albumin for prediction of surgery outcome (beside CD4 count and viral load)	2. In case of dyspnoea postoperatively, consider spontaneous pneumothorax
3. Use of the usual universal protection and equipment	3. Pain control is important, irrespective of whether patients have history of drug abuse
4. Check renal, liver, thyroid function with full blood count and coagulation profile. ECG and MRSA also needed.	4. Antibiotic may also be considered on individual basis especially for those with high CD4 count
5. Smoking is common with HIV and clinician may assess the need to do lung function test and also consider risk of postoperative pneumonia	5. Consider drug–drug interaction (use University of Liverpool website – https://www.hivdruginteractions.org/checker)²⁷
6. Antibiotic may also be considered on individual basis especially for those with high CD4 count.	6. Continue with ART in the perioperative period. Liaise with HIV physician in before and after the operation.

ART: antiretroviral therapy. Further information can be obtained from Masoomi et al.²⁸

Laparoscopic appendicectomy is a preferred approach in HIV patients.²⁸ There is significantly higher laparotomy rate in HIV-positive patients as perforated appendicitis is more frequent in this cohort.⁶ Delayed presentation in HIV-positive patients and surgery were associated with significant higher postoperative morbidity and longer hospital stays.^15,28,29 Overall, HIV-positive patients have significantly higher mortality rates.²⁸ Patients with low CD4 count (<200) are not only likely to have complicated appendicitis but also have a significantly higher mortality rate and a trend towards a higher total postoperative complication rate.^12,13,25 PLWHIV presenting with acute abdominal pain should be treated with high index of suspicion of AA.

Outcomes

The outcome of few studies demonstrates that the lack of cART may be a risk factor for AA among HIV-infected patients.^9,12 Low CD4 count <200 is not a risk factor for having appendicitis,¹⁷ in contrast to other studies.¹² PLWHIV with a history suggestive of AA should be treated differently from the general population in terms of a more cautious approach. Moreover, as morbidity and mortality can be minimized by prompt surgical intervention,³⁰ there is a possibility of treating conservatively in the cases with appendicitis with HIV having low CD4 counts.^9,12 One important challenge for surgeons is establishing the correct diagnosis of AA and excluding conditions that mimic appendicitis. It is worth mentioning, in two case reports, abdominal mycobacterial infection can mimic AA in HIV.^31,32

Limitations

One limitation of this review is that we have only included manuscripts published in English, and we have not included manuscripts written in other languages. Due to limited publications in this field, we are not able to do systematic review.

Conclusion

The prevalence of appendicitis is higher with HIV (8%) in comparison with normal population (0.1%). The HIV can be associated with different precipitating factors that can lead to appendicitis. Among these factors mentioned are the appendix is target for the virus, the chronic state of inflammation of the body, the chance for opportunistic infection to settle in the appendix and high risk associated with surgery in comparison with normal population. Further investigations and research at molecular, cellular, histological, immunological and epidemiological level are needed to understand the exact role of these factors. This will require collaborative research works among different centres in order to recruit adequate numbers of patients and this may take years to achieve. The clinical presentations are similar to normal population, but high suspicion of index is needed to diagnose appendicitis in HIV individuals. Further research is also needed to assess the benefit of using the Alvarado score in establishing the diagnosis of the AA in PLWHIV. Early diagnosis and treatment can significantly help in decreasing the complications. Figure 1 provides step-by-step guide in the management of appendicitis with HIV, and Table 1 provides summary of perioperative care. It is crucial that HIV physicians should be consulted before, during and after surgical treatment of HIV patients with appendicitis.

Footnotes

Author contributions

A.M., S.H.R., E.E., D.M. and M.H.A., all contributed equally in writing, drafting and finalizing the manuscript. A.M. and M.H.A. conceptualized the structure of the analysis paper.

Declaration of conflicting interests

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Funding

The author(s) received no financial support for the research, authorship, and/or publication of this article.

ORCID iD

Mohamed H Ahmed

References

Schleimann

Leth

Krarup

, et al. Acute appendicitis as the initial clinical presentation of primary HIV-1 infection. Open Forum Infect Dis 2018; 5(2): ofy006.

Giiti

Mazigo

Heukelbach

, et al. HIV, appendectomy and postoperative complications at a reference hospital in Northwest Tanzania: cross-sectional study. AIDS Res Ther 2010; 7: 47.

Tan

Lim

Yap

, et al. Abdominal pain in a patient with AIDS. Clin Infect Dis 2004; 39(6): 831–832; 866–867.

Lau

Teoh-Chan

Fan

, et al. The bacteriology and septic complication of patients with appendicitis. Ann Surg 1984; 200(5): 576–581.

Bennion

Baron

Thompson

Jr , et al. The bacteriology of gangrenous and perforated appendicitis – revisited. Ann Surg 1990; 211(2): 165–171.

Neumayer

Makar

Ampel

, et al. Cytomegalovirus appendicitis in a patient with human immunodeficiency virus infection. Case report and review of the literature. Arch Surg 1993; 128(4): 467–468.

Smith

Chung

Constable

, et al. Appendectomy in patients with human immunodeficiency virus: not as bad as we once thought. Surgery 2017; 161(4): 1076–1082.

Duhamel

Gamé

Berlizot

, et al. Présentation urinaire d’une appendicite aiguë: une cause fréquente de retard diagnostique, également chez le sujet infecté par le virus de l’immunodéficience humaine [Urologic presentation of acute appendicitis: a frequent cause of delayed diagnosis, including in HIV infected patients]. Prog Urol 2003; 13(2): 326–328.

Binderow

Shaked

AA.

Acute appendicitis in patients with AIDS/HIV infection. Am J Surg 1991; 162(1): 9–12.

10.

Gigabhoy

Cheddie

Singh

Appendicitis in the HIV era: a South African perspective. Indian J Surg 2018; 80(3): 207–210.

11.

Bedada

Hsiao

Azzie

HIV infection: its impact on patients with appendicitis in Botswana. World J Surg 2019; 43(9): 2131–2136.

12.

Zuniga-Posselt

Velazquez-Fernandez

Presentación clínica de la apendicitis aguda en pacientes inmunocomprometidos por diabetes o VIH/sida. Gac Med Mex 2018; 154(4): 473–479.

13.

Sobnach

Ede

Der

, et al. A study comparing outcomes of appendectomy between HIV-infected and HIV-negative patients. Chirurgia 2019; 114(4): 467–474.

14.

Torno

Shallman

Pill impaction mimicking appendicitis in an HIV-positive patient. AIDS Read 2009; 19(1): 37–38.

15.

Aldeen

Horgan

Macallan

, et al. Is acute appendicitis another inflammatory condition associated with highly active antiretroviral therapy (HAART). HIV Med 2000; 1(4): 252–255.

16.

Crum-Cianflone

Weekes

Bavaro

. Appendicitis in HIV-infected patients during the era of highly active antiretroviral therapy. HIV Med 2008; 9(6): 421–426.

17.

Kobayashi

Watanabe

Yano

, et al. Underestimated amoebic appendicitis among HIV-1-infected individuals in Japan. J Clin Microbiol 2016; 55(1): 313–320.

18.

Faldetta

Kattakuzhy

Wang

, et al. Cytomegalovirus immune reconstitution inflammatory syndrome manifesting as acute appendicitis in an HIV-infected patient. BMC Infect Dis 2014; 14: 313.

19.

Marsilla

Khairunisa

Azyani

, et al. Disseminated histoplasmosis mimicking an acute appendicitis. Malays J Pathol 2019; 41(2): 223–227.

20.

Chetty

Slavin

Miller

RA.

Kaposi’s sarcoma presenting as acute appendicitis in an HIV-1 positive patient. Histopathology 1993; 23(6): 590–591.

21.

Lee

Walsh

HS.

Computed tomography and ultrasonography do not improve and may delay the diagnosis and treatment of acute appendicitis. Arch Surg 2001; 136(5): 556–562.

22.

Rao

Rhea

Novelline

, et al. Helical CT technique for the diagnosis of appendicitis: prospective evaluation of a focused appendix CT examination. Radiology 1997; 202(1): 139–144.

23.

Ohle

O’Reilly

O’Brien

, et al. The Alvarado score for predicting acute appendicitis: a systematic review. BMC Med 2011; 9: 139.

24.

Sobnach

Ede

Van Der Linde

, et al. A retrospective evaluation of the Modified Alvarado Score for the diagnosis of acute appendicitis in HIV-infected patients. Eur J Trauma Emerg Surg 2018; 44(2): 259–263.

25.

Wijesuriya

LI.

Imaging as an aid to the diagnosis of acute appendicitis. Malays Fam Phys 2007; 2(3): 106–109.

26.

Old

Dusing

Yap

, et al. Imaging for suspected appendicitis. Am Fam Phys 2005; 71(1): 71–78.

27.

https://www.hivguidelines.org/hiv-care/perioperative-management/#tab_0 (accessed 29 June 2020).

28.

Masoomi

Mills

Dolich

, et al. Outcomes of laparoscopic and open appendectomy for acute appendicitis in patients with acquired immunodeficiency syndrome. Am Surg 2011; 77(10): 1372–1376.

29.

Kitaoka

Saito

Tokuuye

Significance of CD4+ T-cell count in the management of appendicitis in patients with HIV. Can J Surg 2015; 58(6): 429–430.

30.

Bova

Meagher

Appendicitis in HIV-positive patients. Aust N Z J Surg 1998; 68(5): 337–339.

31.

Dezfuli

Jones

, et al. Tuberculosis mimicking acute appendicitis in patients with human immunodeficiency virus infection. Clin Infect Dis 1994; 18(4): 650–651.

32.

Visvanathan