Thyrotoxicosis is a common endocrine condition that may be secondary to a number of underlying processes. Thyroid storm (also known as thyroid or thyrotoxic crisis) represents the severe end of the spectrum of thyrotoxicosis and is characterized by compromised organ function. Whilst rare in the modern era, the mortality rate remains high, and prompt consideration of this endocrine emergency, with specific treatments, can improve outcomes.
Abraham, P. and Acharya, S.(2010) Current and emerging treatment options for Graves’ hyperthyroidism . Therapeut Clin Risk Managem6: 29-40.
2.
Bahn, R. ( 2010) Graves’ opthalmopathy. N Engl J Med362: 726-738.
3.
Burch, H.B. and Wartofsky, L. ( 1993) Life-threatening thyrotoxicosis. Thyroid storm. Endocrinol Metab Clin North Am22: 263-277.
4.
Erdogan, M.F., Gulec, S., Tutar, E., Baskal, N. and Erdogan, G. ( 2003) A stepwise approach to the treatment of amiodarone-induced thyrotoxicosis. Thyroid13: 205-209.
5.
Ezer, A., Caliskan, K., Parlakgumus, A., Belli, S., Kozanoglu, I. and Yildirim, S.(2009) Preoperative therapeutic plasma exchange in patients with thyrotoxicosis . J Clin Apharesis11: 111-114.
6.
Food and Drug Administration (2010) Propylthiouracil tablets. http://www.fda.gov/Safety/MedWatch/SafetyInformation/ucm209256.htm (accessed 2 August 2010).
7.
Kreisner, E., Lutzky, M. and Gross, J.(2010) Charcoal hemoperfusion in the treatment of levothyroxine intoxication . Thyroid20: 209-212.
8.
Malozowski, S. and Chiesa, A. ( 2010) Propylthiouracil-Induced Hepatotoxicity and Death. Hopefully, Never More. J. Clin. Endocrinol. Metab95: 3161-3163.
9.
Matfin, G. ( 2009) Disorders of endocrine control of growth and metabolism , In: Porth, C.M. and Matfin, G. (eds). Pathophysiology: Concepts of Altered Health States, 8th edn, Wolters Kluwer Health: Philadelphia, PA.
10.
Nayak, B. and Burman, K. ( 2006) Thyrotoxicosis and thyroid storm. Endocrinol Metab Clin N Am35: 663-686.
11.
Tsai, W.C., Pei, D., Wang, T., Wu, D.A., Li, J.C., Wei, C.L. et al. (2005) The effect of combination therapy with propylthiouracil and cholestyramine in the treatment of Graves’ hyperthyroidism. Clin Endocrinol (Oxf) 62: 521-524.
