Abstract
Important advances in treating critically ill patients often proceed in fits and starts. Thematic studies are often published in clusters and concordant negative or positive results can accelerate shifts in clinical practice. The past few years have seen several important studies that address key knowledge gaps in treating critically ill patients. In this article, 6 studies that address key questions in the implementation of lung-protective ventilation, the use of oscillatory ventilation in severe acute respiratory distress syndrome, transfusion practices during upper gastrointestinal bleeds, and the use of total parenteral nutrition in critically ill patients are reviewed. These studies should shift the way we ventilate, transfuse, and nourish patients in the ICU.
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