Jaceosidin, a natural flavone, has been reported to have anti-tumorigenic, anti-oxidant, and anti-inflammatory activities. However, the anti-adipogenic effects of jaceosidin have not been investigated. In this study, we demonstrate that jaceosidin suppresses adipocyte differentiation and cellular lipid accumulation without cytotoxicity. Jaceosidin also suppresses the mRNA and protein expression of adipogenesis-related genes. To our knowledge, these results are the first evidence of the anti-adipogenic effects of jaceosidin in 3T3-L1 adipocytes and suggest the use of jaceosidin as a treatment for obesity.
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