Abstract
Obesity is a worldwide threat, affecting both developed and developing countries. Guggulipid obtained from gum guggul is widely prescribed in Ayurveda for various medical conditions including obesity. The present study was designed to investigate the effect of guggulsterone on the expression of adiponectin, the adipokine that regulates glucose and fatty acid metabolism. 3T3-L1 cells were treated with guggulsterone E / Z isomer [(GE) /(GZ)] and mRNA levels of adiponectin as well as PPARγ (a transcription factor that regulates adiponectin expression) were monitored. Treatment of 3T3-L1 cells with GE / GZ during differentiation into adipocytes led to reduced mRNA levels of adiponectin. However, no effect on the mRNA levels of adiponectin was observed when fully differentiated adipocytes were treated with either GE or GZ.
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