The liver has the crucial role in the regulation of various physiological processes and in the excretion of endogenous waste metabolites and xenobiotics. Liver structure impairment can be caused by various factors including microorganisms, autoimmune diseases, chemicals, alcohol and drugs. The plant kingdom is full of liver protective chemicals such as phenols, coumarins, lignans, essential oils, monoterpenes, carotenoids, glycosides, flavonoids, organic acids, lipids, alkaloids and xanthenes. Apiaceae plants are usually used as a vegetable or as a spice, but their other functional properties are also very important. This review highlights the significance of caraway, dill, cumin, aniseed, fennel, coriander, celery, lovage, angelica, parsley and carrot, which are popular vegetables and spices, but possess hepatoprotective potential. These plants can be used for medicinal applications to patients who suffer from liver damage.
JannuV, BaddamPG, BoorgulaAK, JambulaSR. (2012) A review on hepatoprotective plants. International Journal of Drug Development and Research, 4, 1–8.
2.
KashawV, NemaA, AbhinavA. (2011) Hepatoprotective prospective of herbal drugs and their vesicular carriers – a review. International Journal of Research in Pharmaceutical and Biomedical Sciences, 2, 360–374.
3.
KumarA. (2012) A review on hepatoprotective herbal drugs. International Journal of Research in Pharmacy and Chemistry, 2, 92–102.
4.
CorsiG, BiasciD. (1998) Secretory structures and localization of alkaloids in Conium maculatum L. (Apiaceae). Annals of Botany, 81, 157–162.
5.
AćimovićM, KostadinovićLj, PopovićS, DojěinovićN. (2015). Apiaceae seeds as functional food. Journal of Agricultural Sciences (Belgrade), 60, 237–246.
6.
Kovaě-BesovićE, ČeljoA, MulabegovićN, DurićK. (2008) Determination of coumarins and flavonoids in fruits of Apiaceae. Planta Medica, 74, PB26.
7.
KreydiyyehSI, UstaJ, KnioK, MarkossianS, DagherS. (2003) Aniseed oil increases glucose absorption and reduces urine output in the rat. Life Science, 74, 663–673.
8.
ErdoganE, KayaA, RagbetliMC, OzbekH, CengizN. (2004) A morphological study of the hepatoprotective effects of anise (Pimpinella anisum) extract in experimentally induced acute liver degeneration in rats. Van Tip Dergisi Medical Journal, 11, 69–74.
9.
IacobellisNS, CantorePL, CapassoF, SenatoreF. (2005) Antibacterial activity of Cuminum cyminum L. and Carum carvi L. essential oils. Journal of Agriculture and Food Chemistry, 53, 57–61.
10.
CeylanE, OzbekH, AgaogluZ. (2005) Investigation of the level of the median lethal dose (LD50) and the hypoglycemic effect in healthy and diabetic mice of Pimpinella anisum L. fruit essential oil extract. Yüzüncü Yιl Üniversitesi Saĝlιk Bilimleri Dergisi, 1–2, 39–47.
11.
PandaS. (2008) The effect of Anethum graveolens L. (dill) on corticosteroid induced diabetes mellitus: involvement of thyroid hormones. Phytotherapy Research, 22, 1695–1697.
HeamalathaS, SwarnalathaS, DivyaM, GandhiLakshimi R, GomathiE. (2011) Pharmacognostical, pharmacological, investigation on Anethum graveolans Linn: A review. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2, 564–574.
14.
JohriKR. (2011) Cuminum cyminum and Carum carvi: An update. Pharmacognosy Review, 5, 63–72.
15.
ShahatAA, IbrahimAY, HendawySF, OmerEA, HammoudaFM, Abdel-RahmanFH, SalehMA. (2011) Chemical composition, antimicrobial and antioxidant activities of essential oils from organically cultivated fennel cultivars. Molecules, 16, 1366–1377.
16.
OsmanN. (2013) The role of antioxidant properties of celery against lead acetate induced hepatotoxicity and oxidative stress in irradiated rats. Arab Journal of Nuclear Sciences and Application, 46, 339–346.
17.
JeyabalanJ, AqilF, SoperL, SchultzDJ, GuptaRC. (2015) Potent chemopreventive/antioxidant activity detected in common spices of the Apiaceae family. Nutrition and Cancer, 67, 1201–1207.
18.
NajdaA, DyduchJ, BrzozowskiN. (2008) Flavonoid content and antioxidant activity of caraway roots (Carum carvi L.). Vegetable Crops Research Bulletin, 68, 127–133.
19.
AgrahariP, SinghDK. (2014) A review on the pharmacological aspects of Carum carvi. Journal of Biology and Earth Sciences, 4, M1–M13.
20.
LisiewskaZ, KmiecikW, KorusA. (2006) Content of vitamin C, carotenoids, chlorophylls and polyphenols in green parts of dill (Anethum graveolens L.) depending on plant height. Journal of Food Composition and Analysis, 19, 134–140.
21.
AlinianaS, RazmjooaJ, ZeinaliH. (2016) Flavonoids, anthocyanins, phenolics and essential oil produced in cumin (Cuminum cyminum L.) accessions under different irrigation regimes. Industrial Crops and Products, 81, 49–55
22.
BettaiebI, BourgouS, SritiJ, MsaadaK, LimamF, MarzoukB. (2011) Essential oils and fatty acids composition of Tunisian and Indian cumin (Cuminum cyminum L.) seeds: a comparative study. Journal of the Science of Food and Agriculture, 91, 2100–2107.
23.
MaM, MuT, SunH, ZhangM, ChenJ, YanZ. (2015) Optimization of extraction efficiency by shear emulsifying assisted enzymatic hydrolysis and functional properties of dietary fiber from deoiled cumin (Cuminum cyminum L.). Food Chemistry, 179, 270–277.
24.
DenevRV, KuzmanovaIS, MomchilovaSM, Nikolova-DamyanovaBM. (2011) Resolution and quantification of isomeric fatty acids by silver ion HPLC: fatty acid composition of aniseed oil (Pimpinella anisum, Apiaceae). Journal of AOAC International, 94, 4–8.
25.
CoşgeB, KiralanM, GürbüzB. (2008) Characteristics of fatty acids and essential oil from sweet fennel (Foeniculum vulgare Mill. var. dulce) and bitter fennel fruits (F. vulgare Mill. var. vulgare) growing in Turkey. Natural Product Research, 22, 1011–1016.
26.
KoudelaM, PetřikovaK. (2008) Nutritional compositions and yield of sweet fennel cultivars-Foeniculum vulgare Mill. ssp. vulgare var. azoricum (Mill.) Thell. Horticultural Science (Prague), 35, 1–6.
27.
SalamaZA, El BazFK, GaafarAA, ZakiMF. (2015) Antioxidant activities of phenolics, flavonoids and vitamin C in two cultivars of fennel (Foeniculum vulgare Mill.) in responses to organic and bio-organic fertilizers. Journal of the Saudi Society of Agricultural Sciences, 14, 91–99.
28.
ClydeDD, BertiniJ, DmochowskiR, KoopH. (1979) The vitamin A and C content of Coriandrum sativum and the variations in the loss of the latter with various methods of food preparation and preservation. Qualitas Plantarum, 28, 317–322.
29.
CengizN, ÖzbekH, HimA. (2008) Hepatoprotective effects of Pimpinella anisum seed extract in rats. Pharmacology online, 3, 870–874.
30.
ShadAA, ShahHU, BakhtJ, ChoudharyMI, UllahJ. (2011) Nutraceutical potential and bioassay of Apium graveolens L. grown in Khyber Pakhtunkhwa-Pakistan. Journal of Medicinal Plants Research, 5, 5160–5166.
31.
SertelS, EichhornT, PlinkertPK, EfferthT. (2011) Chemical composition and antiproliferative activity of essential oil from the leaves of a medicinal herb, Levisticum officinale, against UMSCC1 head and neck squamous carcinoma cells. Anticancer Research, 31, 185–192.
32.
ShafaghatA. (2011) Chemical constituents, antimicrobial and antioxidant activity of the hexane extract from root and seed of Levisticum persicum Freyn and Bornm. Journal of Medicinal Plants Research, 5, 5127–5131.
33.
BhatZA, KumarD, ShahMY. (2011) Angelica archangelica Linn. is an angel on earth for the treatment of diseases. International Journal of Nutrition, Pharmacology, Neurological Disease, 1, 36–50.
34.
Al-HowirinyTA, Al-SohaibaniMO, El-TahirKH, RafatullahS. (2003) Preliminary evaluation of the anti-inflammatory and anti-hepatotoxic activities of ‘parsley’ Petroselinum crispum in rats. Journal of Natural Remedies, 3, 54–62.
35.
TunaliT, YaratA, YanardagR, OzcelikF, OzsoyO, ErgenekonG, EmekliN. (1999) Effect of parsley (Petroselinum crispum) on the skin of STZ induced diabetic rats. Phytotherapy Research, 13, 138–141.
36.
ÖzcanMM, ChalchatJC. (2007) Chemical composition of carrot seeds (Daucus carota L.) cultivated in Turkey: characterization of the seed oil and essential oil. Grasas y Aceites, 58, 359–365.
37.
StraubO. (1987) In Key to Carotenoids. 2nd Ed, PfanderF. (Ed). Birkhauser Verlag, Basel. 296.
38.
OlsonJA. (1989) Provitamin A function of carotenoids: the conversion of β-carotene into vitamin A. Journal of Nutrition, 119, 105–108.
39.
MeshkatalsadatMH, SalahvarziS, AminiradpoorR, AbdollahiA. (2012) Identification of essential oil constituents of caraway (Carum carvi) using ultrasonic assist with headspace solid phase microextraction (UA-HS-SPME). Digest Journal of Nanomaterials and Biostructures, 7, 637–640.
40.
Seidler-łożykowskaK, KędziaB, KarpińskaE, BocianowskiJ. (2013) Microbiological activity of caraway (Carum carvi L.) essential oil obtained from different origin. Acta Scientiarum Agronomy, 35, 495–500.
41.
AćimovićM, OljaěaS, TeševićV, TodosijevićM, ĐisalovJ. (2014) Evaluation of caraway essential oil from different production areas of Serbia. Horticultural Science (Prague), 41, 122–130.
42.
FotiMC, IngoldKU. (2003) Mechanism of inhibition of lipid peroxidation by γ-terpinene, an unusual and potentially useful hydrocarbon antioxidant. Journal of Agricultural and Food Chemistry, 51, 2758–2765.
43.
KazemipoorM, MohamedRadzi CWJB, HajifarajiM, HaerianBS, MosaddeghMH, CordellGA. (2013) Antiobesity effect of caraway extract on overweight and obese women: A randomized, triple-blind, placebo-controlled clinical trial. Evidence-Based Complementary and Alternative Medicine, Article ID 928582, doi:10.1155/2013/928582.
44.
SamojlikI, LakićN, Mimica-DukićN, Daković-SvajcerK, BožinB. (2010) Antioxidant and hepatoprotective potential of essential oils of coriander (Coriandrum sativum L.) and caraway (Carum carvi L.) (Apiaceae). Journal of Agricultural and Food Chemistry, 58, 8848–8853.
45.
FatemiF, AllamehA, KhalafiH, AshrafihelanJ. (2010) Hepatoprotective effects of γ-irradiated caraway essential oils in experimental sepsis. Applied Radiation and Isotopes, 68, 280–285.
46.
BailerJ, AichingerT, HacklG, de HueberK, DachlerM. (2001) Essential oil content and composition in commercially available dill cultivars in comparison to caraway. Industrial Crops and Products, 14, 229–239.
47.
RanaVS, BlazquezAM. (2014) Chemical composition of the essential oil of Anethum graveolens aerial parts. Journal of Essential Oil Bearing Plants, 17, 1219–1223.
48.
SinghG, MauryaS, De LampasonaMP, CatalanC. (2005) Chemical constituents, antimicrobial investigations, and antioxidative potentials of Anethum graveolens L. essential oil and acetone extract: Part 52. Journal of Food Science, 70, 208–215.
49.
KazemiM. (2015) Phenolic profile, antioxidant capacity and anti-inflammatory activity of Anethum graveolens L. essential oil. Natural Product Research, 29, 551–553.
50.
MalhotraSK, VashishthaBB. (2007) Response of Indian dill (Anethum sowa) and European dill (Anethum graveolens) varieties to different agro-techniques. Indian Journal of Agricultural Sciences, 77, 519–522.
51.
JanaS, ShekhawatGS. (2010) Anethum graveolens: An Indian traditional medicinal herb and spice. Pharmacognosy Reviews, 4, 179–184.
52.
AćimovićM, MilićN. (2015) Dill in traditional medicine and modern phytotherapy. Materies Medicales, 35, 23–35.
53.
RabehNM, AborayaAO. (2014) Hepatoprotective effect of dill (Anethum graveolens L.) and fennel (Foeniculum vulgare) oil on hepatotoxic rats. Pakistan Journal of Nutrition, 13, 303–309.
54.
TamilarasiR, SivanesanD, KanimozhiP. (2012) Hepatoprotective and antioxidant efficacy of Anethum graveolens Linn in carbon tetrachloride induced hepatotoxicity in albino rats. Journal of Chemical and Pharmaceutical Research, 4, 1885–1888.
55.
AliWSH. (2013). Hypolipidemic and antioxidant activities of Anethum graveolens against acetaminophen induced liver damage in rats. World Journal of Medical Sciences, 8, 387–392.
56.
ThuppiaA, JitvaropasR, SaenthaweesukS, SomparnN, KaulpiboonJ. (2011) Hepatoprotective effect of the ethanolic extract of Anethum graveolens L. on paracetamol-induced hepatic damage in rats. Planta Medica, 77, PF18.
57.
YazdanparastR, AlaviM. (2001) Antihyperlipidaemic and antihypercholesterolaemic effects of Anethum graveolens leaves after removal of furocoumarins. Cytobios, 105, 185–191.
58.
OshaghiEA, KhodadadiI, TavilaniH, GoodarziMT. (2016) Effect of dill tablet (Anethum graveolens L) on antioxidant status and biochemical factors on carbon tetrachloride-induced liver damage on rat. International Journal of Applied Basic Medicinal Research, 6, 111–114.
59.
TopalU, SasakiM, GotoM, OtlesS. (2008) Chemical compositions and antioxidant properties of essential oils from nine species of Turkish plants obtained by supercritical carbon dioxide extraction and steam distillation. International Journal of Food Sciences and Nutrition, 59, 619–634.
60.
WannerJ., BailS, JirovetzL, BuchbauerG, SchmidtE, GochevV, GirovaT, AtanasovaT, StoyanovaA. (2010) Chemical composition and antimicrobial activity of Cumin oil (Cuminum cyminum, Apiaceae). Natural Product Communications, 5, 1355–1358.
61.
ArunaK, RukkumaniR, VarmaPS, MenonVP. (2005) Therapeutic role of Cuminum cyminum on ethanol and thermally oxidized sunflower oil induced toxicity. Phytotherapy Research, 19, 416–421.
62.
KodeA, RajagopalanR, PenumathsaSV, MenonVP. (2005) Effect of ethanol and thermally oxidized sunflower oil ingestion on phospholipid fatty acid composition of rat liver: protective role of Cuminum cyminum L. Annals of Nutrition and Metabolism, 49, 300–303.
63.
KumarA, KumarR, KumarN, NathA, SinghJK, MohammadA. (2011) Protective effect of Cuminum cyminum and Coriandrum sativum on profenofos induced liver toxicity. International Journal of Pharmaceutical and Biological Archives, 2, 1405–1409.
64.
MushtaqA, AhmadM, JabeenQ, SaqibA, WajidM, AkramMA. (2014) Hepatoprotective investigations of Cuminum cyminum dried seeds in nimesulide intoxicated albino rats by phytochemical and biochemical methods. International Journal of Pharmacy and Pharmaceutical Sciences, 6, 506–510.
65.
NishadhA, SelviV, MahalakshmiR. (2013) Hepatoprotective effect of Vernonia cinerea and cumin seeds on carbon tetrachloride induced hepatic oxidative stress. International Journal of Drug Development and Research, 5, 215–220.
66.
ShojaiiA, FardMA. (2012) Review of pharmacological properties and chemical constituents of Pimpinella anisum. ISRN Pharmaceutics, 2012, 510795.
67.
AćimovićM, TeševićV, TodosijevićM, OljaěaS, DolijanovićŽ. (2015) Essential oil content and composition of aniseed. Matica Srpska Journal for Natural Sciences (Novi Sad), 128, 67–75.
68.
SinghG, KapoorIP, PandeySK, SinghUK, SinghRK. (2002) Studies on essential oils: part 10; antibacterial activity of volatile oils of some spices. Phytotherapy Research, 16, 680–682.
69.
El-SayedMGA, ElkomyA, SaharS, El-BannaAH. (2015) Hepatoprotective effect of Pimpinella anisum and Foeniculum vulgare against carbon tetrachloride induced fibrosis in rats. World Journal of Pharmaceutical Sciences, 4, 78–88.
70.
JamshidzadehA, HeidariR, RazmjouM, KarimiF, MoeinMR, FarshadO, AkbarizadehAR, ShayestehMRH. (2015) An in vivo and in vitro investigation on hepatoprotective effects of Pimpinella anisum seed essential oil and extracts against carbon tetrachloride-induced toxicity. Iranian Journal of Basic Medical Sciences, 18, 205–211.
71.
AćimovićM, TeševićV, TodosijevićM, DjisalovJ, OljaěaS. (2015) Compositional characteristics of the essential oil of Pimpinella anisum and Foeniculum vulgare grown in Serbia. Botanica Serbica, 39, 9–14.
72.
MotaAS, MartinsMR, ArantesS, LopesVR, BettencourtE, PombalS, GomesAC, SilvaLA. (2015) Antimicrobial activity and chemical composition of the essential oils of Portuguese Foeniculum vulgare fruits. Natural Product Communications, 10, 673–676.
ChaudharySK, NiladriM, NemaNK, SantanuB, SahaBP, MukherjeePK. (2013) Angiotensin converting enzyme inhibition activity of fennel and coriander oils from India, Natural Product Communications, 8, 671–672.
75.
RochaDK, MatosO, NovoMT, FigueiredoAC, DelgadoM, MoiteiroC. (2015) Larvicidal activity against Aedes aegypti of Foeniculum vulgare essential oils from Portugal and Cape Verde. Natural Product Communications, 10, 677–682.
76.
TognoliniM, BallabeniV, BertoniS, BruniR, ImpicciatoreM, BarocelliE. (2007) Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis. Pharmacological Research, 56, 254–260
77.
RatherMA, DarBA, SofiSN, BhatBA, QurishiMA. (2012) Foeniculum vulgare: A comprehensive review of its traditional use, phytochemistry, pharmacology, and safety. Arabian Journal of Chemistry, in press.
ChoiEM, HwangJK. (2004) Anti-inflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare. Fitoterapia, 75, 557–565.
82.
De MarinoS, GalaF, BorboneN, ZolloF, VitaliniS, VisioliF, IorizziM. (2007) Phenolic glycosides from Foeniculum vulgare fruit and evaluation of antioxidative activity. Phytochemistry, 68, 1805–1812.
83.
El-Sheikhel-SA, GalalAA. (2015) Toxic effects of sub-chronic exposure of male albino rats to emamectin benzoate and possible ameliorative role of Foeniculum vulgare essential oil. Environmental Toxicology and Pharmacology, 39, 1177–1188.
84.
ChoHI, KimKM, KwakJH, LeeSK, LeeSM. (2013) Protective mechanism of anethole on hepatic ischemia/reperfusion injury in mice. Journal of Natural Products, 76, 1717–1723.
85.
AćimovićM, OljaěaS, JaćimovićG, DražićS, TasićS. (2011) Benefits of environmental conditions for growing coriander in Banat region, Serbia. Natural Product Communication, 6, 1465–1468.
86.
MandalS, MandalM. (2015) Coriander (Coriandrum sativum L.) essential oil: Chemistry and biological activity. Asian Pacific Journal of Tropical Biomedicine, 5, 421–428.
87.
MarangoniC, de MouraNF. (2011) Antioxidant activity of essential oil from Coriandrum sativum L. in Italian salami. Ciência e Tecnologia de Alimentos, Campinas, 31, 124–128.
88.
DarugheF, BarzegarM, SahariMA. (2012) Antioxidant and antifungal activity of coriander (Coriandrum sativum L.) essential oil in cake. International Food Research Journal, 19, 1253–1260.
89.
WangensteenH, SamuelsenAB, MalterudKE. (2004) Antioxidant activity in extracts from coriander. Food Chemistry, 88, 293–297.
90.
DumanAD, TelciI, DayisoyluKS, DigrakM, Demirtasİ, AlmaMH. (2010) Evaluation of bioactivity of linalool-rich essential oils from Ocimum basilucum and Coriandrum sativum varieties. Natural Product Communications, 5, 969–974.
91.
DuarteAF, FerreiraS, OliveiraR, DominguesFC. (2013) Effect of coriander oil (Coriandrum sativum) on planktonic and biofilm cells of Acinetobacter baumannii. Natural Product Communications, 8, 673–678.
92.
SilvaF, FerreiraS, DuarteA, MendonçaDI, DominguesFC. (2011) Antifungal activity of Coriandrum sativum essential oil, its mode of action against Candida species and potential synergism with amphotericin B. Phytomedicine, 19, 42–47.
93.
SilvaF, FerreiraS, QueirozJA, DominguesFC. (2011) Coriander (Coriandrum sativum L.) essential oil: its antibacterial activity and mode of action evaluated by flow cytometry. Journal of Medicinal Microbiology, 60, 1479–1486.
94.
FurlettiVF, TeixeiraP, Obando-PeredaG, MardeganRC, SartorattoA, FigueiraGM, DuarteRMT, RehderVLG, DuarteMCT, HoflingJF (2011) Action of Coriandrum sativum L. essential oil upon oral Candida albicans biofilm formation. Evidence-Based Complementary and Alternative Medicine, 20, 1–9.
95.
AissaouiA, ZiziS, IsrailiZH, LyoussiB. (2011) Hypoglycemic and hypolipidemic effects of Coriandrum sativum L. in Merionesshawi rats. Journal of Ethnopharmacology, 137, 652–661.
96.
JabeenQ, BashirS, LyoussiB, GilaniAH. (2009) Coriander fruit exhibits gut modulatory, blood pressure lowering and diuretic activities. Journal of Ethnopharmacology, 122, 123–130.
97.
KansalL, SharmaV, SharmaA, LodiS, SharmaSH. (2011) Protective role of Coriandrum sativum (coriander) extracts against lead nitrate induced oxidative stress and tissue damage in the liver and kidney in male mice. International Journal of Applied Biology and Pharmaceutical Technology, 2, 65–83.
98.
JohnNAA, ShobanaG, KeerthanaK. (2014) Protective effect of Coriander sativum L. on cadmium induced toxicity in albino rats. World Journal of Pharmaceutical Sciences, 3, 525–534.
99.
MoustafaAH, AliEMM, MoselheySS, ToussonE, El-SaidKS. (2014) Effect of coriander on thioacetamide-induced hepatotoxicity in rats. Toxicology and Industrial Health, 30, 621–629.
100.
SreelathaS, PadmaPR, UmadeviM. (2009) Protective effects of Coriandrum sativum extracts on carbon tetrachloride-induced hepatotoxicity in rats. Food and Chemical Toxicology, 47, 702–708.
101.
RamadanMM, AlgaderNNEA, El-KamaliHH, GhanemKZ, FarragARH. (2013) Chemopreventive effect of Coriandrum sativum fruits on hepatic toxicity in male rats. World Journal of Medical Sciences, 8, 322–333.
102.
PandeyA, BigoniyaP, RajV, PatelKK. (2011) Pharmacological screening of Coriandrum sativum Linn. for hepatoprotective activity. Journal of Pharmacy and Bioallied Sciences, 3, 435–441.
103.
SreelathaS, PadmaPR, UmadeviM. (2009) Protective effects of Coriandrum sativum extracts on carbon tetrachloride-induced hepatotoxicity in rats. Food Chemistry and Toxicology, 47, 702–708.
104.
CharlesDJ. (2013) Antioxidant Properties of Spices, Herbs and Other Sources. Springer, New York, 1–610.
105.
AćimovićM, CvetkovićM, StankovićJ, MaleněićĐ, KostadinovićLj. (2015) Compound analysis of essential oils from lovage and celery fruits obtained by headspace extraction. Annals of Scientific Work of the Faculty of Agriculture in Novi Sad, 39, 44–51.
106.
SowbhagyaHB. (2014) Chemistry, technology, and nutraceutical functions of celery (Apium graveolens L.): an overview. Critical Reviews in Food Science and Nutrition, 54, 389–398.
107.
KootiW, Ali-AkbariS, Asadi-SamaniM, GhaderyH, Ashtary-LarkyD. (2014) A review on medicinal plant of Apium graveolens. Advanced Herbal Medicine, 1, 48–59.
108.
SinghA, HandaSS. (1995) Hepatoprotective activity of Apium graveolens and Hygrophila auriculata against paracetamol and thioacetamide intoxication in rats. Journal of Ethnopharmacology, 49, 119–126.
109.
SultanaS, AhmedS, JahangirT, SharmaS. (2005) Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism and altered hepatic foci development. Cancer Letters, 221, 11–20.
110.
KolarovicJ, PopovicM, MikovM, MiticR, GvozdenovicLj. (2009) Protective effects of celery juice in treatments with doxorubicin. Molecules, 14, 1627–1638.
111.
BelalNM. (2011) Hepatoprotective effect of feeding celery leaves mixed with chicory leaves and barley grains to hypercholesterolemic rats. Asian Journal of Clinical Nutrition, 3, 14–24.
112.
ShivashriC, RajarajeshwariT, RajasekarP. (2013) Hepatoprotective action of celery (Apium graveolens) leaves in acetaminophen-fed freshwater fish (Pangasius sutchi). Fish Physiology and Biochemistry, 38, 1057–1069.
QuassintiL, MaggiF, BarboniL, RicciutelliM, CorteseM, PapaF, GarulliC, KalogrisC, VittoriS, BramucciM. (2014) Wild celery (Smyrnium olusatrum L.) oil and isofuranodiene induce apoptosis in human colon carcinoma cells. Fitoterapia, 97, 133–141.
115.
WenpingLi, JingshanShi, PapaF, MaggiF, XiupingChen (2016) Isofuranodiene, the main volatile constituent of wild celery (Smyrnium olusatrum L.), protects D-galactosamin/lipopolysacchride-induced liver injury in rats. Natural Product Research, 30, 1162–1165.
116.
Abd El-HamidSR, AbeerYI, HendawySF (2009) Anti-inflammatory, antioxidant, anti-tumor and physiological studies on Levisticum officinale Koch plant. Planta Medica, 75, PE62. DOI: 10.1055/s-0029–1234623
117.
PrisâcaruC. (2014) Research study on the assessment of the antitoxic action of various phytopreparates derived from the vegetal products of Levisticum officinale. Lucrâriştienţifice, Seria Horticulturâ, 57, 11–16.
118.
PasquaG, MonacelliB, SilvestriniA. (2003) Accumulation of essential oils in relation to root differentiation in Angelica archangelica L. European Journal of Histochemistry, 47, 87–90.
119.
BhatZA, KumarD, ShahMY. (2011) Angelica archangelica Linn. is an angel on earth for the treatment of diseases. International Journal of Nutrition, Pharmacology, Neurological Diseases, 1, 36–50.
120.
KumarD, BhatZA. (2012) Anti-anxiety activity of methanolic extracts of different parts of Angelica archangelica Linn. Journal of Traditional and Complementary Medicine, 2, 235–241.
121.
FraternaleD, FlaminiG, RicciD. (2014) Essential oil composition and antimicrobial activity of Angelica archangelica L. (Apiaceae) roots. Journal of Medicinal Food, 17, 1043–1047.
122.
PrakashB, SinghP, GoniR, RainaAK, DubeyNK (2015) Efficacy of Angelica archangelica essential oil, phenyl ethyl alcohol and α- terpineol against isolated molds from walnut and their antiaflatoxigenic and antioxidant activity. Journal of Food Science and Technology, 52, 2220–2228.
123.
ElgoharyAA, ShafaaMW, RaafatBM, RizkRA, MetwallyFG, SalehAM. (2009) Prophylactic effect of Angelica archangelica against acute lead toxicity in albino rabbits. Romanian Journal of Biophysics, 19, 259–275.
124.
YehML, LiuCF, HuangCL, HuangTC. (2003) Hepatoprotective effect of Angelica archangelica in chronically ethanol-treated mice. Pharmacology, 68, 70–73.
125.
RomeilahRM, FayedSA, MahmoudGI. (2010) Chemical compositions, antiviral and antioxidant activities of seven essential oils. Journal of Applied Sciences Research, 6, 50–62.
126.
LopezMG, Sanchez-MendozaIR, Ochoa-AlejoN. (1999) Compartive study of volatile components and fatty acids of plants and in vitro cultures of parsley (Petroselinum crispum (Mill) Nym ex Hill). Journal of Agricultural and Food Chemistry, 47, 3292–3296.
127.
KreydiyyehSI, UstaJ, KaoukI, Al-SadiR. (2001) The mechanism underlying the laxative properties of parsley extract. Phytomedicine, 8, 382–388.
128.
NielsenSE, YoungJF, DaneshvarB, LauridsenST, KnuthsenP, SandstromB. (1999) Effect of parsley intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers for oxidative stress in human subjects. British Journal of Nutrition, 81, 447–455.
129.
ChavesDSA, FrattaniFS, AssafimM, de AlmeidaAP, ZingaliRB, CostaSS. (2011) Phenolic chemical composition of Petroselinum crispum extract and its effect on haemostasis. Natural Product Communications, 6, 961–964.
130.
KamalT, Abd-ElhadyE, SadekK, ShukryM. (2014) Effect of parsley (Petroselium crispum) on carbon tetrachloride-induced acute hepatotoxicity in rats. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 5, 1524–1534.
131.
TroncosoL, GuijaE. (2007) Petroselinum sativum (perejil) antioxidant and hepatoprotective effects in rats with paracetamol-induced hepatic intoxication. Anales de la Facultad de Medicina Universidad Nacional Mayor de San Marcos, 68, 333–343.
132.
JassimAM. (2013) Protective effect of Petroselinum crispum (parsley) extract on histopathological changes in liver, kidney and pancreas induced by sodium valproate in male rats. Kufa Journal for Veterinary Medical Sciences, 4, 20–27.
133.
BolkentS, YanardagR, Ozsoy-SacanO, Karabulut-BulanO. (2004) Effects of parsley (Petroselinum crispum) on the liver of diabetic rats: a morphological and biochemical study. Phytotherapy Research, 18, 996–999.
134.
Ozsoy-SacanO, YanardagR, OrakH, OzgeyY, YaratA, TunaliT. (2006) Effects of parsley (Petroselinum crispum) extract versus glibornuride on the liver of streptozotocin-induced diabetic rats. Journal of Ethnopharmacology, 104, 175–181.
135.
FejesS, KeryA, BlazovicsA, LugasiA, LemberkovicsE, PetriG, SzokeE. (1998) Investigation of the in vitro antioxidant effect of Petroselinum crispum (Mill.) Nym. ex A. W. Hill. Acta Pharmaceutica Hungarica, 68, 150–156.
136.
NairVY, BalakrishananN, AntonySantiago JV. (2015) Petroselinum crispum extract attenuates hepatic steatosis in rats fed with fructose enriched diet. Bratislava Medical Journal, 116, 547–553.
137.
AćimovićM, StankovićJ, CvetkovićM, IgnjatovM, NikolićLj. (2016) Chemical characterization of essential oil from seeds of wild and cultivated carrots from Serbia. Botanica Serbica, 40, 55–60.
138.
MarzoukiH, KhaldiA, FalconieriD, PirasA, MarongiuB, MolicottiP, ZanettiS. (2010) Essential oils of Daucus carota subsp. carota of Tunisia obtained by supercritical carbon dioxide extraction. Natural Product Communications, 5, 1955–1958.
139.
SinghK, SinghN, ChandyA, ManigauhaA. (2012) In vivo antioxidant and hepatoprotective activity of methanolic extracts of Daucus carota seeds in experimental animals. Asian Pacific Journal of Tropical Biomedicine, 2, 385–388.
140.
ShobaS, PatilPA, VivekV. (2008) Hepatoprotective activity of Daucus carota L. aqueous extract against paracetamol, isoniazid and alcohol induced hepatotoxicity in male Wistar rats. Pharmacologyonline, 3, 776–787.
141.
BishayeeA, SarkarA, ChatterjeeM. (1995) Hepatoprotective activity of carrot (Daucus carota L.) against carbon tetrachloride intoxication in mouse liver. Journal of Ethnopharmacology, 47, 69–74.
142.
BalasubramaniamP, PariL, MeninVP. (1998) Protective effect of carrot (Daucus carota L) against lindane induced hepatotoxicity in rats. Phytotherapy Research, 12, 434–436.
143.
JainPK, KhuranaN, PounikarY, PatilS, GajbhiyeA. (2012) Hepatoprotective effect of carrot (Daucus carota L.) on paracetamol intoxicated rats. International Journal of Pharmacology and Pharmaceutical Technology, 1, 115–120.
144.
ShebabyWN, DaherCF, El-SibaiM, Bodman-SmithK, MansourA, KaramMC, MrouehM. (2015) Antioxidant and hepatoprotective activities of the oil fractions from wild carrot (Daucus carota ssp. carota). Pharmaceutical Biology, 53, 1285–1294.
