Capgermacrene C,a New Sesquiterpenoid from a Bornean Soft Coral,Capnella sp.

Abstract

A new bicyclogermacrene, capgermacrene C (1), along with a known compound, 1,4-peroxy-5-muurolene (2), were isolated from a population of Bornean soft coral Capnella sp. The structures of these metabolites were determined by extensive spectroscopic analysis, including NMR, and HRESIMS. Both compounds were subjected to antibacterial activity tests against antibiotic resistant clinical bacteria, but produced only negligible inhibition.

Keywords

Nephtheidae Soft coral Sesquiterpenoid Bicyclogermacrene

References

Blunt

, Copp

, Keyzers

Munro

Mhg

, Prinsep

. (2016) Marine natural products. Natural Product Reports, 33, 382-431.

Wright

, Goclik

, König

. (2003) Oxygenated analogues of gorgosterol and ergosterol from the soft coral Capnella lacertiliensis. Journal of Natural Products, 66, 157-160.

Wei

, Sung

, Duh

, Chen

, Sheu

, Yang

. (2013) Anti-inflammatory activities of natural products isolated from soft corals of Taiwan between 2008 and 2012. Marine Drugs, 11, 4083-4126.

Phan

, Ng

, Kim

, Jeon

, Palaniveloo

, Vairappan

. (2015) Capgermacrenes A and B, bioactive secondary metabolites from a Bornean soft coral, Capnella sp. Marine Drugs, 13, 3103-3115.

Handayani

, Edrada

, Proksch

, Wray

, Witte

, van

Ofwegen L

, Kunzmann

(1997) New oxygenated sesquiterpenes from the Indonesian soft coral Nephthea chabrolii. Journal of Natural Products, 60, 716-718.

Lampman

, Pavia

, Kriz

, Vyvyan

. (2010) Spectroscopy, 4^th ed., Brooks/Cole: 10 Davis Drive, Belmont, USA, 128-130.

Blackman

, Bowden

, Coll

, Frick

, Mahendran

, Mitchell

. (1982) Several new cembranoid diterpenes from Nephthea brassica and related diterpenes from a Sarcophyton species. Australian Journal of Chemistry, 35, 1873-1880.

Duh

, Wang

, Chung

, Chou

, Dai

. (2000) Cytotoxic cembrenolides and steroids from the Formosan soft coral Sarcophyton crassocaule. Journal of Natural Products, 63, 1634-1637.

Nagashima

, Asakawa

(2001) Sesqui- and diterpenoids from two Japanese and three European liverworts. Phytochemistry, 56, 347-352.

Supplementary Material

Please find the following supplemental material available below.

For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.

For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.

0.00 MB

0.84 MB