A new guaiane-type sesquiterpenoid, 10β-O-methyl-1αH,5αH-guaia-6-en-4β-ol (1) along with two known compounds, 10-O -methyl alismoxide (2) and alismoxide (3) were isolated from a population of Bornean soft coral Xenia stellifera. The structure of this metabolite was elucidated based on spectroscopic data such as NMR and HRESIMS. These compounds were evaluated for their biological activity against adult T-cell leukemia cell line.
KönigGM, CollJC, BowdenBF, GulbisJM, MacKayMF, LabarreSC, LaurentD. (1989) The structure determination of a xenicane diterpene from Xenia garciae. Journal of Natural Products, 52, 294–299.
2.
AndrianasoloEH, HaramatyL, WhiteE, LutzR, FalkowskiP. (2014) Mode of action of diterpene and characterization of related metabolites from the soft coral, Xenia elongata. Marine Drugs, 12, 1102–1115.
3.
HuberT, WeisheitL, MagauerT. (2015) Synthesis of Xenia diterpenoids and related metabolites isolated from marine organisms. Beilstein Journal of Organic Chemistry, 11, 2521–2539.
4.
KelmanD, KashmanY, RosenbergE, KushmaroA, LoyaY. (2006) Antimicrobial activity of Red Sea corals. Marine Biology, 149, 357–363.
5.
HegazyMEF, MohamedTA, AlhammadyMA, ShaheenAM, RedaEH, ElshamyAI, AzizM, ParéPW. (2015) Molecular architecture and biomedical leads of terpenes from Red Sea marine invertebrates. Marine Drugs, 13, 3154–3181.
6.
ElshamyAI, NassarMI. (2015) Xenia terpenoids as anticancer promoters. Journal of Biologically Active Products from Nature, 5, 78–107.
7.
EllitheyMS, LallN, HusseinAA, MeyerD. (2013) Cytotoxic, cytostatic and HIV-1 PR inhibitory activities of the soft coral Litophyton arboretum. Marine Drugs, 11, 4917–4936.
8.
BohlmannF, JakupovicJ. (1979) Neue labdan-derivate und sesquiterpene aus Silphium-arten. Phytochemistry, 18, 1987–1992.
9.
AnjaneyuluASR, GowriPM. (2000) Two new guaiane sesquiterpenoids from the soft coral Sarcophyton buitendijki of the Andaman and Nicobar Islands of the Indian Ocean. Indian Journal of Chemistry, 39B, 773–778.
10.
JadulcoRC, KochM, KakuleTB, SchmidtEW, OrendtA, HeH, JansoJE, CarterGT, LarsonEC, PondC, MatainahoTK, BarrowsLR. (2014) Isolation of pyrrolocins A-C: cis- and trans-decalin tetramic acid antibiotics from an endophytic fungal-derived pathway. Journal of Natural Products, 77, 2537–2544.
11.
LiuY, MaJ, ZhaoQ, LiaoC, DingL, ChenL, ZhaoF, QiuF. (2013) Guaiane-type sesquiterpenes from Curcuma phaeocaulis and their inhibitory effects on nitric oxide production. Journal of Natural Products, 76, 1150–1156.
12.
MaQ, HanL, BiX, WangX, MuY, GuanP, LiL, HuangX. (2016) Structures and biological activities of the triterpenoids and sesquiterpenoids from Alisma orientale. Phytochemistry, 131, 150–157.
13.
PhanCS, KamadaT, KobayashiK, HamadaT, VairappanCS. (2018) 15-Deoxy-isoxeniolide-A, new diterpenoid from a Bornean soft coral, Xenia sp. Natural Product Research, 32, 202–207.