Two New Lobane Diterpenes from a Bornean Soft Coral Sinularia sp

Abstract

Two new lobane diterpenoids, prenyl-α-elemenone (1) and ent-prenyl-β-elemene (2), along with a known compound, α-murrolene (3) were isolated from a population of Bornean soft coral Sinularia sp. The structures of these compounds were elucidated on the basis of spectroscopic, including 2D NMR, and HR-MS data. These compounds were tested for their cytotoxicity and antibacterial activities against antibiotic resistant clinical strains.

Keywords

Alcyoniidae Borneo Soft coral Diterpene Lobane

References

Lakshmi

, Kumar

(2009) Metabolites from Sinularia species. Natural Product Research, 23, 801–850

Shmul

, Kashman

, Benayahu

(2007) Abruptosides A, a novel glycolipid from the Kenyan soft coral Sinularia abrupta. Natural Product Communications, 2, 51–54

, Lee

, Lu

, Su

. (2012) Triangulene C, a new cubitane-based diterpenoid from the soft coral Sinularia triangula. Natural Product Communications, 7, 479–480

Wang

, Chen

, Dai

, Hwang

, Wang

, Wen

, Wu

, Sung

. (2014) New cembranoids from the soft coral Sinularia arborea. Natural Product Communications, 9, 361–362

Lin

, Su

, Lee

. (2013) Cembranoids from the cultured soft coral Sinularia gibberosa. Natural Product Communications, 8, 1363–1364

Chai

, Wang

, Dai

, Duh

. (2000) A cytotoxic lobane diterpene from the Formosan soft coral Sinularia inelegans. Journal of Natural Products, 63, 843–844.

Vairappan

, Intan

Irna Zanil

, Kamada

, Palaniappan

(2012) Isopropyl(ene)-type cembrene diterpene an important secondary metabolite in soft coral Sinularia flexibilis of Tun Sakaran Marine Park, Malaysia. Journal of Tropical Biology and Conservation, 9, 200–205.

Palaniveloo

, Ramachandram

, Vairappan

. (2014) Cembrane diterpenes as chemotaxonomical markers for Sinularia flexibilis. Journal of Tropical Biology and Conservation, 11, 103–116.

Edrada

, Proksch

, Wray

, Witte

, van Ofwegen

(1998) Four new bioactive lobane diterpenes of the soft coral Lobophytum pauciflorum from Mindoro, Philippines. Journal of Natural Products, 61, 358–361.

10.

Bonnard

, Jhaumeer-Laulloo

, Bontemps

, Banaigs

, Aknin

(2010) New lobane and cembrane diterpenes from two Comorian soft corals. Marine Drugs, 8, 359–372.

11.

Wright

, Nielson

, Tapiolas

, Liptrot

, Motti

. (2012) A great barrier reef Sinularia sp. yields two new cytotoxic diterpenes. Marine Drugs, 10, 1619–1630.

12.

Yamada

, Arima

, Nagamitsu

, Johmoto

, Uekusa

, Eguchi

, Shin-ya

, Cane

Ikeda

(2015) Novel terpenes generated by heterologous expression of bacterial terpene synthase genes in an engineered Streptomyces host. Journal of Antibiotics, 68, 385–394.

13.

Kashman

, Rudi

, Gutman-Naveh

(1978) 7-Hydroxy (and acetoxy)-α-mullolene from the soft coral Heteroxenia fuscescens. Tetrahedron, 34, 1227–1229.

14.

Espinel-Ingroff

, Bartlett

, Chaturvedi

, Ghannoum

, Hazen

, Pfaller

, Rinaldi

, Walsh

. (2001) Optimal susceptibility testing conditions for detection of azole resistance in Aspergillus spp.: NCCLS collaborative evaluation. National committee for clinical laboratory standards. Antimicrobial Agents and Chemotherapy, 45, 1828–1835.

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