Study of the chemical constituents of Acronychia pedunculata (L.) Miq. (Rutaceae) stems collected in Taiwan led to the isolation and identification of eight known and three new acetophenones, named acrophenone A (1), B (2), and C (3). Of them, acrovestone (5), acropyrone (6) and acrovestenol (7), which are dimer compounds, strikingly inhibited the proliferation of human leukemia cell lines.
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SuCR, KuoPC, WangML, LiouMJ, DamuAG, WuTS. (2003) Acetophenone derivatives from Acronychia pedunculata. Journal of Natural Products, 66, 990–993;
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WuTS, WangML, JongTT, McPhailAT, McPhailDR, LeeKH. (1989) X-ray crystal structure of acrovestone, a cytotoxic principle from Acronychia pedunculata. Journal of Natural Products, 52, 1284–1289.
