Phytochemical investigations of Alchemilla persica Rothm. growing in Iran were performed taking into account both the volatile and polar constituents. The hydrodistilled essential oil was analysed by GC-MS that revealed the presence of alkanes (27.8%), diterpenoids (19.6 %) and sesquiterpene hydrocarbons (17.1%) as the major constituents, while tannins and flavonol glycosides were identified as the most abundant constituents of the methanol extract by HPLC-MS. A. persica can be a valuable source of ellagitannins and polyphenols.
ErgeneB, AcikaraOB, BakarF, SaltanG, NebiogluS. (2010) Antioxidant activity and phytochemical analysis of Alchemilla persica Rothm. Journal of Faculty of Pharmacy of Ankara University, 39, 145–154.
2.
DavisPH. (1972) Flora of Turkey and the East Aegean Islands. Edinburgh University Press, Edinburgh.
3.
MozaffarianV. (2007) A dictionary of Iranian plant names. Farhang Moaser, Tehran.
4.
KhatamsazM. (1992) Flora of Iran, No. 6. Research Institute of Forests and Rangelands, Tehran.
5.
TrouillasP, CallisteCA, AllaisDP, SimonA, MarfakA, DelageC, DurouxJL. (2003) Antioxidant, anti-inflammatory and antiproliferative properties of sixteen water plant extracts used in Limousin countryside as herbal teas. Food Chemistry, 80, 399–407.
6.
IvanchevaS, NikolovaM, TsvetkovaR. (2006) Pharmacological activities and biologically active compounds of Bulgarian medicinal plants. Phytochemistry: Advances in Research, 87–103.
7.
KiselovaY, IvanovaD, ChervenkovT, GerovaD, GalunskaB, YankovaT. (2006) Correlation between the in vitro antioxidant activity and polyphenol content of aqueous extracts from Bulgarian herbs. Phytotheraphy Research, 20, 961–965.
8.
KiselovaY, IvanovaD, GalunskaB, ChervenkovT, GerovaD, YankovaT. (2006) Polyphenol content and in vitro antioxidant activity of aqueous-alcoholic extracts from Bulgarian herbs. Bulletin of the Medical Institute after Mehrabyan, 78–83.
9.
KiselovaY, IvanovaD, TrendafilovaA, MarinovaS, ZapryanovaY, TodorovaM. (2011) Antioxidant activity and total phenolic content of fractions from selected Bulgarian medicinal plants. Acta Fytotechnica et Zootechnica, 1, 13–16.
10.
OktyabrskayO, VysochinaG, MuzykaN, SamoilovaZ, KukushkinaT, SmirnovaG. (2009) Assessment of anti-oxidant activity of plant extracts using microbial test systems. Journal of Applied Microbiology, 106, 1175–1183.
11.
MenkovicN, SavikinK, TasicS, ZdunicG, StesevicD, MilosavljevicS, VincekD. (2011) Ethnobotanical study on traditional uses of wild medicinal plants in Prokletije Mountains (Montenegro). Journal of Ethnopharmacology, 133, 97–107.
12.
DermaderosianA, BeutlerJA. (2001) The Review of Natural Products, 3rded. Facts and Comparisons publishing group, St. Louis, MO.
13.
GeigerC, ScholzE, RimplerH. (1994) Ellagitannins from Alchemilla xanthochlora and Potentilla erecta. Planta Medica, 60, 384–385.
14.
Küpeli AkkolE, DemirelMA, Bahadir AcikaraO, SüntarI, ErgeneB, IlhanM, OzbilginS, SaltanG, KeleşH, TekinM. (in press) Phytochemical analyses and effects of Alchemilla mollis (Buser) Rothm. and Alchemilla persica Rothm. in rat endometriosis model. Archives of Gynecology and Obstetrics, doi: 10.1007/s00404-015-3665-6.
15.
MillsS, BoneK. (2000) Principle and Practice of Phytotherapy: Modern Herbal Medicine. Churchill Livingstone, Edinburgh.
SchimmerO, EschelbachH. (1997) Esculetin in Alchemilla speciosa: identification and antimutagenic properties. Die Pharmazie, 52, 476–478.
19.
KayaB, MenemenY, SaltanFZ. (2012) Flavonoids in the endemic species of Alchemilla L. (section Alchemilla L. subsection Calycanthum Rothm. Ser. Elatae Rothm.) from North-east Black Sea Region in Turkey. Pakistan Journal of Botany, 44, 595–597.
20.
KayaB, MenemenY, SaltanFZ. (2012) Flavonoid compounds identified in Alchemilla L. species collected in the North-eastern Black Sea Region of'Turkey. African Journal of Traditional, Complementary and Alternative Medicines, 9, 418–425.
21.
TurkM, KayaB, MenemenY, OguztuzunS. (2011) Apoptotic and necrotic effects of plant extracts belonging to the genus Alchemilla L. species on HeLa cells in vitro. Journal of Medicinal Plants Research, 5, 4566–4571.
22.
StanilovaM, GorgorovR, TrendafilovaA, NikolovaM, VitkovaA. (2012) Influence of nutrient medium composition on in vitro growth, polyphenolic content and antioxidant activity of Alchemilla mollis. Natural Product Communications, 7, 761–766.
23.
FalcheroL, CoppaM, EspostiS, TavaA. (2008) Essential oil composition of Alchemilla alpina L. em. Buser from Western Alpine Pastures. Journal of Essential Oil Research, 20, 542–545.
MaggiF, TirilliniB, VittoriS, SagratiniG, PapaF. (2009) Analysis of the volatile components of Onosma echioides (L.) L. var. columnae Lacaita growing in Central Italy. Journal of Essential Oil Research, 21, 441–447.
26.
AdamsRP. (2007) Identification of essential oil components by gas chromatography/mass spectroscopy. Allured Publishing Co., Carol Stream, IL.
27.
NIST 08. (2008) Mass spectral library (NIST/EPA/NIH). Gaithersburg, USA: National Institute of Standards and Technology.
28.
FFNSC 2, Flavors and Fragrances of Natural and Synthetic Compounds. (2012). Mass spectral database. Kyoto: Shimadzu Corps.
29.
MaggiF, BilekT, CristalliG, PapaF, SagratiniG, VittoriS. (2009) Comparison of the characterization of the fruit-like aroma of Teucrium flavum L. subsp. flavum by hydrodistillation and solid-phase micro-extraction. Journal of the Science of Food and Agriculture, 89, 2505–2518.
30.
Alves-PereiraIMS, Fernandes-FerreiraM. (1998) Essential oils and hydrocarbons from leaves and calli of Origanum vulgare ssp. virens. Phytochemistry, 48, 795–799.
31.
CarriereF, ChangvardieffP, GilG, PeanM, SigoillotJC, TapieP. (1990) Paraffinic hydrocarbons in heterotrophic, photomixotrophic and photoautotrophic cell suspensions of Euphorbia characias L. Plant Science, 71, 93–98.
32.
MenaP, CalaniL, Dall'AstaC, GalavernaG, Garcia-VigueraC, BruniR, CrozierA, Del RioD. (2012) Rapid and comprehensive evaluation of (poly)phenolic compounds in pomegranate (Punica granatum L.) juice by UHPLC-MS”. Molecules, 17, 14821–14840.
33.
HagerTJ, HowardLR, LiyanageR, LayJO, PriorRL. (2008) Ellagitannin composition of blackberry as determined by HPLC-ESI-MS and MALDI-TOF-MS. Journal of Agricultural and Food Chemistry, 56, 661–669.
34.
Alvarez-FernandezMA, CerezoAB, Cañete-RodriguezAM, TroncosoAM, Garcia-ParrillaMC. (2015) Composition of nonanthocyanin polyphenols in alcoholic-fermented strawberry products using LC-MS (QTRAP), high-resolution MS (UHPLC-Orbitrap-MS), LC-DAD, and antioxidant activity. Journal of Agricultural and Food Chemistry, 63, 2041–2051.