Immunomodulatory Action of Triterpene Glycosides Isolated from the Sea Cucumber Actinocucumis typica . Structure-Activity Relationships

Abstract

Stimulation of lysosomal activity and ROS formation in mouse peritoneal macrophages by five triterpene glycosides, typicosides A₁ (1), A₂ (2), B₁ (3), C₁ (4) and C₂ (5) has been studied and compared with their cytotoxic activities. Glycosides 1–3 possess moderate activities, but the most cytotoxic glycoside 5 is not active. Typicoside C₁ (4), with low toxicity, was proved to be the most active concerning stimulation of ROS formation. This is the first example of a triterpene glycoside from sea cucumbers with low cytotoxicity, but which demonstrates a strong immunostimulatory effect on mouse peritoneal macrophages in vitro.

Keywords

Triterpene glycosides Lysosomal activity Macrophages ROS formation Immunostimulators

References

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