Immunomodulatory Action of Monosulfated Triterpene Glycosides from the Sea Cucumber Cucumaria okhotensis: Stimulation of Activity of Mouse Peritoneal Macrophages
Free accessResearch articleFirst published online December, 2010
Immunomodulatory Action of Monosulfated Triterpene Glycosides from the Sea Cucumber Cucumaria okhotensis: Stimulation of Activity of Mouse Peritoneal Macrophages
Six monosulfated triterpene glycosides, frondoside A1 (1), okhotoside B1 (2), okhotoside A1-1 (3), frondoside A (4), okhotoside A2-1 (5) and cucumarioside A2-5 (6), isolated from Cucumaria okhotensis Levin et Stepanov, stimulate spreading and lysosomal activity of mouse macrophages and ROS-formation in the macrophages. The highest macrophage spreading and stimulation of their lysosomal activity was induced by glycosides 1, 4 and 6. All glycosides similarly stimulate ROS formation in macrophages, but glycoside 2 caused minimal stimulation.
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