Our investigation of the stem of Dendrobium pulchellum resulted in the isolation of four known bibenzyls, chrysotobibenzyl (1), chrysotoxine (2), crepidatin (3) and moscatilin (4). The present study reveals for the first time the ability of these four compounds to facilitate anoikis and inhibit the growth of lung cancer cells in anchorage-independent condition. The preliminary data obtained disclose the inhibitory effect on cancer cell metastasis of the isolated compounds, and provide an important new approach for cancer drug development.
HuangQ, LuG, ShenHM, ChungMCM, OngCN. (2007) Anti-cancer properties of anthraquinones from rhubarb. Medicinal Research Reviews, 27, 609–630.
9.
MuangmanS, ThippornwongM, TohtongH., (2005) Anti-metastatic effects of curcusone B, a diterpene fromJatropha curcas. In Vivo, 19, 265–268.
10.
ZhangGN, ZhongLY, Annie BlighSW, GuoYL, ZhangCF, ZhangM, WangZT, XuLS. (2005) Bi-bicyclic and bi-tricyclic compounds from Dendrobium thyrsiflorum. Phytochemistry, 66, 1113–1120.
11.
ZhangCF, WangM, WangL, IinumaM, ZhangM, XuLS, WangZT. (2008) Chemical constituents of Dendrobium gratiosissimum and their cytotoxic activities. Indian Journal of Chemistry, 47B, 952–956.
12.
HoCK, ChenCC. (2003) Moscatilin from the orchid Dendrobium loddigesii is a potential anticancer agent. Cancer Investigation, 21, 729–736.
13.
ChenTH, PanSL, GuhJH, LiaoCH, HuangDY, ChenCC, TengCM. (2008) Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage. Clinical Cancer Research, 14, 4250–4258.
14.
TsiAC, PanSL, LiaoCH, GuhJH, WangSW, SunHL, LiuYN, ChenCC, ShenCC, ChangYL, TengCM. (2010) Moscatilin, a bibenzyl derivative from the India orchid Dendrobium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo. Cancer Letters, 292, 163–170.
SritularakB, LikhitwitayawuidK., (2009) New bisbibenzyls from Dendrobium falconeri. Helvetica Chimica Acta, 92, 740–744.
17.
SritularakB, AnuwatM, LikhitwitayawuidK., (2011) A new phenanthrenequinone from Dendrobium draconis. Journal of Asian Natural Products Research, 13, 251–255.
18.
LiS, HeS, ZhongS, DuanX, YeH, ShiJ, PengA, ChenL., (2011) Elution-extrusion counter-current chromatography separation of five bioactive compounds from Dendrobium chrysototxum Lindl. Journal of Chromatography A, 1218, 3124–3128.
19.
OnoM, ItoY, MasuokaC, KogaH, NoharaT., (1995) Antioxidative constituents from Dendrobii Herba (stems of Dendrobium spp.). Food Science and Technology International, 2, 115–120.
20.
MajumderPL, ChatterjeeS., (1989) Crepidatin, a bibenzyl derivative from the orchid Dendrobium crepidatum. Phytochemistry, 28, 1986–1988.
21.
MajumderPL, SenRC. (1987) Moscatilin, a bibenzyl derivative from the orchid Dendrobium moscatum. Phytochemistry, 26, 2121–2124.
22.
ZhangX, XuJK, WangNL, KuriharaH, YaoXS. (2008) Antioxidant phenanthrenes and lignans from Dendrobium nobile. Journal of Chinese Pharmaceutical Sciences, 17, 314–318.
23.
IshimaruK, NonakaGI, NishiokaI., (1987) Gallic acid esters of proto-quercitol, quinic acid and (-)-shikimic acid from Quercus mongolica and Q. myrsinaefolia. Phytochemistry, 26, 1501–1504.
24.
DeyamaT. (1983) The constituents of Eucommia ulmoides Oliv. I. Isolation of (+)-medioresinol di-O-β-D-glucopyranoside. Chemical & Pharmaceutical Bulletin, 31, 2993–2997.
25.
HalimH, ChunhachaP, SuwanboriruxK, ChanvorachoteP., (2011) Anti-cancer and antimetastatic activities of renieramycin M, a marine tetrahydroisoquinoline alkaloid, in human non-small cell lung cancer cells. Anticancer Research, 31, 193–201.
