Direct flow injection/electrospray ionization/ion trap tandem mass spectrometry was used to investigate the presence of proanthocyanidins (PAs) in the methanolic extract of B. simaruba bark. Additionally, an LC-ESI-MS qualitative study was performed by using a monolithic stationary phase. The fragmentation pattern obtained evidenced the presence in B. simaruba bark of PAs belonging to the series of polymers of epicatechin, along with their glycosilated derivatives.
BadilloVM, SchneeL, Benitez deRC. (1985) Clave de las Familias de Plantas Superiores de Venezuela, 7th ed., Caracas.
2.
ArvigoR, BalikM. (1993). Rainforest remedies. In: One Hundred Healing Herbs of Belize. Lotus Press, Twin Lakes, WI.
3.
CarreteroME, Lòpez-PerezJL, AbadMJ, BermejoP, TilletS, IsraelA, Noguera-PB. (2008) Preliminary study of the anti-inflammatory activity of hexane extract and fractions from Bursera simaruba (Linneo) Sarg. (Burseraceae) leaves Journal of Ethnopharmacology, 116, 11–15.
4.
SosaS, BalickMJ, ArvigoR, EspositoRG, PizzaC, AltinierG, TubaroA. (2002) Screening of the topical anti-inflammatory activity of some Central American plants. Journal of Ethnopharmacology, 81, 211–215.
5.
MaldiniM, MontoroP, PiacenteS, PizzaC. (2009) Phenolic compounds from Bursera simaruba Sarg. bark: phytochemical investigation and quantitative analysis by tandem mass spectrometry. Phytochemistry, 122, 430–433.
6.
RoyB, DuttaS, ChowdharyA, BasakA, DasguptaS. (2008) Design, synthesis and RNase A inhibition activity of catechin and epicatechin and nucleobase chimeric molecules. Bioorganic & Medicinal Chemistry Letters, 18, 5411–5414.
7.
BenavidesA, MontoroP, BassarelloC, PiacenteS, PizzaC. (2006) Flavonoids and isoflavonoids from Gynerium sagittatum. Journal of Pharmaceutical and Biomedical Analysis, 40, 639–647.
8.
GoncalvesC, DinisT; BatistMT. (2005) Antioxidant properties of proanthocyanidins of Uncaria tomentosa bark decoction: a mechanism for anti-inflammatory activity. Phytochemistry, 66, 89–98.
9.
ZhangW, LiuH, XieK, YinL, LiY, Kwik-UribeCL, ZhuX. (2006) Procyanidin dimer B2 [epicatechin-(4β-8)-epicatechin] suppresses the expression of cyclooxygenase-2 in endotoxin-treated monocytic cells. Biochemical and Biophysical Research Communications, 345, 508–515.
10.
IkegamiT, TanakaN. (2004) Monolithic columns for high-efficiency HPLC separations. Current Opinion in Chemical Biology, 8, 527–533.
11.
RodriguesCM, RinaldoD, dos SantosL, MontoroP, PiacenteS, PizzaC, Hiruma-LimaCA, BritoARMS, VilegasW. (2007) Metabolic fingerprinting using direct flow injection electrospray ionization tandem mass spectrometry for the characterization of proanthocyanidins from the barks of Hancornia speciosa. Rapid Comunications in Mass Spectrometry, 21, 1907–1914.
