Five new triterpene saponins (1–5) were isolated from the stems of Akebia quinata. On the basis of extensive spectroscopic analysis, including 2D NMR data, and chemical evidence, the structures of the new compounds were determined to be 3β-[(O-β-D-glucopyranosyl-(1→3)-α-L-arabinopyranosyl)oxy]-29-hydroxyolean-12-en-28-oic acid O-α-L-rhamnopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester (1), 3β-[(O-β-D-glucopyranosyl-(1→3)-O-[α-L-rhamnopyranosyl-(1→2)]-α-L-arabinopyranosyl)oxy]-29-hydroxyolean-12-en-28-oic acid O-α-L-rhamnopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester (2), 3β-[(O-β-D-glucuronopyranosyl-(1→3)-O-[α-L-rhamnopyranosyl-(1→2)]-α-L-arabinopyranosyl)oxy]-29-hydroxyolean-12-en-28-oic acid O-α-L-rhamnopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester (3), 3β-[(O-β-D-glucopyranosyl-(1→3)-α-L-arabinopyranosyl)oxy]-23,29-dihydroxyolean-12-en-28-oic acid O-α-L-rhamnopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester (4), and 3β-[(O-β-D-glucopyranosyl-(1→3)-O-[α-L-rhamnopyranosyl-(1→2)]-α-L-arabinopyranosyl)oxy]-23,29-dihydroxy-olean-12-en-28-oic acid O-α-L-rhamnopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester (5), respectively.
ChoiJ, JungH, LeeK, ParkH. (2005) Antinociceptive and anti-inflammatory effects on the saponin and sapogenins obtained from the stem of Akebia quinata. Journal of Medicinal Food, 8, 78–85.
2.
LiuG, ZhengJ, YuZ, ZhangJ, LinR. (2005) Study on sterols and triterpenes from the stems of Akebia quinata. Zhongyaocai, 28, 1060–1062.
3.
LiuG, MaS, ZhengJ, ZhangJ, LinR. (2007) Two new triterpenoid saponins from Akebia quinata (Thunb.) Dence. Journal of Integrative Plant Biology, 9, 196–201.
4.
MimakiY, DoiS, KurodaM, YokosukaA. (2007) Triterpene glycosides from the stem of Akebia quinata. Chemical & Pharmaceutical Bulletin, 55, 1319–1324.
