Chemical Burns make up 3% of burns center admissions and have a mortality rate that varies from 4.1 to 13%. There are over 25,000 products capable of causing chemical burns. These injuries may cause significant tissue necrosis and have the potential for systemic toxicity. This article gives an overview of the various types of chemical burns along with their management. Chemical warfare agents and extravasation injuries will also be briefly discussed.
Anderson WJ, Anderson JR1988. Hydrofluoric Acid Burns of the hand: mechanism of injury and treatment. J Hand Surgery (Am)13(1): 52—7.
2.
Arnold JL2004. Chemical Warfare Agents Emedicine.
3.
Balali-Mood M., Hefazi M.2005. The pharmacology, toxicology and medical treatment of sulphur mustard poisoning. Fundam Clin Pharmacol19(5): 297—315.
4.
Bertolini JC1992. Hydrofluoric acid: a review of toxicity. J Emerg Med10(2): 163—8.
5.
Boyce DE, Dickson WA1993. Wet Cement - A poorly recognised cause of full thickness skin burns. Injury24(9): 615—7.
6.
Brennan RJ, Waeckerle, Sharp TW, Lillibridge SR2000. National Burn Care Review, 2000. National Burn Care Review. http://www.baps.co.uk/documents/nbcr.pdf
7.
Brown D., Borschel G.2004. Michigan Manual ofPlastic Surgery .
8.
Brown VKH, Box VL, Simpson BJ1975. Decontamination procedures for skin exposed to phenolic substances. Arch Environ Health20: 1.
Chan TC, Williams SR, Clark RF1995. Formic acid burns resulting in systemic toxicity . Ann Emerg Med26(3): 383—6.
11.
Chick LR, Borah G.1990. Calcium Carbonate gel therapy for hydrofluoric acid burns of the hand. Plast ReconstructiveSurg86: 935—40.
12.
Chou TD, Lee TW et al. 2001. The management of white phosphorus burns . Burns27(5): 492—7.
13.
Clare RA, Krenzelok EP1988. Clinical burns secondary to elemental metal exposure; 2 case reports. AnnJ Emerg Med6: 355—7.
14.
Comer JB1984. Extravasation from intravenous Phenytoin. American Journal of IV therapy and clinical nutrition11: 23—2429.
15.
Conning DM, Haynes MJ1970. The dermal toxicity of phenol: an investigation of the most effective first-aid measures. Br J Ind Med27: 155.
16.
Cox K., Stuart-Harris R. et al. 1988. The management of cytotoxic drug extravasation: guidelinea drawn up by a working party for the Clinical Oncological Society Australia. Medical Journal of Australia148: 185—9.
17.
Davidson EC1927. The treatment of alkali and acid burns. Ann Surg85: 481y.
18.
Davis KG2002. Acute management of white phosphorus burns. Mil Med167(1): 83—4.
19.
Dunser MW, Ohlbauer M. et al. 2004. Critical care management of major hydrofluoric acid burns: a case report, review of the literature and recommendations for therapy. Burns30(4): 391—8.
20.
Earnest MP, Marx JA, Drury LR1983. Complications of intravenous Phenytoin for acute treatment of seizures. JAMA249(6): 7623—765.
21.
Eldad A., Wisoki M. et al. 1995. Phosphorus burns: evaluation of various modalities for primary treatment. J Burn Care Rehabil16(1): 49—55.
22.
Emergency Management of Severe Burns Manual, UK Version for the British Burns Association1996.
23.
Erdmann D., Hussman J., Kucan JO1996. Treatment of severe alkali burns. Burns22: 141—6.
Goolby TV, Lombardo FA2006. Extravasation of chemotherapeutic agents: prevention and treatment. Semin Oncol33(1): 139—43.
26.
Graudins A., Burns MJ, Aaron CK1997. Regional intravenous infusion of calcium gluconate for hydrofluoric acid burns of the upper extremity. Ann Emerg Med30(5): 604—7.
27.
Gruber RP, Laub DR, Vistnes LM1975. The effect of hydrotherapy on the clinical course and pH of experimental cutaneous chemical burns. Plast Reconstr Surg55: 200.
28.
Hagan HJ, Hastings H.1988. Extravasation of Phenytoin in the hand. J Hand Surg13A(6): 942—3.
29.
Hanna DR1992. Purple glove syndrome: a complication of IV Phenytoin . Journal of Neuroscience Nursing24(6): 341—5.
30.
Hansborough JF, Zapata-Sirivent R., Dominic W., Sullivan J., Boswick J., Wang XW1985. Hydrocarbon contact injuries. J Trauma25(3): 250—2.
31.
Hettiaratchy S., Dziewulski P.2004. ABC of burns: pathophysiology and types of burns . BMJ328(7452): 1427—9.
32.
Hodgkinson DJ, Irons GB, Williams TJ1978. Chemical burns and skin preparation solutions. Surg Gynecol Obstet147: 534—6.
33.
Holstege CP, Kirk M., Siddell FR1997. Chemical Warfare—Nerve Agent Poisoning. Crit Care Clin13(4): 923—42.
34.
Horch R., Spiker G., Stark GB1994. Phenol burns and intoxications. Burns20(1): 45—50. http://www.globalsecurity.org/military/systems/munitions/wp.htm
Landstein HN, Duman H., Seeliq D. et al. 2002. Retrospective study of the management of chemotherapeutic extravasation injury. Ann Plast Surg499(4): 369—7.
46.
Latenser BA, Lucktong TA2000. Anhydrous Ammonia burns: case presentation and literature review. J Burn Care Rehabil21(1 part 1): 40—2.
47.
Laurie SWS, Wilson KL et al. 1984. Intravenous extravasation injuries: the effectiveness of Hyaluronidase in their treatment. Annals ofPlastic Surgery13: 191—4.
48.
Lee RC, Astumian RD1996. The physicochemical basis of thermal and non-thermal `burns' injuries. Burns7: 509—19.
49.
Le HQ, Knudson SJ2006. Exposure to a First World War blistering agent . Emerg Med J23(4): 296—9.
50.
Martin PH, Carver N., Petros AJ1994. Use of liposuction and saline washout for the treatment of extensive subcutaneous extravasation of corrosive drugs. Br J Anaesth72(6): 702—4.
51.
Matey P., Allison KP, Sheehan TM, Gower JP2000. Chromic acid burns: early aggressive excision is the best method to prevent systemic toxicity. J Burn Care Rehabil21(3): 241—5.
52.
US Army Medical Research Institute of Chemical Defence.1995. Medical Management of chemical casualties handbook . 2nd Ed..
53.
Merat S., Perez JP, Ruttimen M. et al. 2003. Acute poisoning by chemical warfare agent: sulphur mustard. Ann Fr Anest Reanim22(2): 85.
Moran KD, O'Reilly T., Munster AM1987. Chemical burns: a 10-year experience. Am J Surg53: 652—3.
56.
Morley SE, Humzah D., McGregor JC, Gilbert PM1996. Cement-related burns. Burns22(8): 646—7.
57.
Mozingo DW, Smith AA et al. 1998. Chemical Burns; US Army Institute of Surgical Research. Journal of Trauma28(5): 642—7.
58.
Mullet T., Zoeller T.1985. Fatal hydrofluoric acid cutaneous exposure with refractory ventricular fibrillation. J Burn Care Rehabil8(3): 216—9.
59.
Murray J.1990. Cold, chemical and irradiation injuries. In: J.G. McCarthy ed. Plastic Surgery5436—51.
60.
Narayanan V., Josty IC et al. 2000. Lime burns in a professional footballer — an unusual hazard. Burns26(8): 754—6.
61.
Negi AS, Anand SC1985. A Textbook ofPhysical Chemistry .
62.
O'Brien TJ, Hanna DR1998. Incidence and clinical consequence of the purple glove syndrome in patients receiving IV Phenytoin. Neurology51(4): 1034—9.
63.
Peters WJ1984. Alkali burns from wet cement. Can Med Assoc J130: 902—3.
64.
Rao VK, Feldman PD, Dibbell DG1988. Extravasation injury to the hand by intravenous Phenytoin . J Neurosurg68: 967—9.
65.
Renz BM, Sherman R.1994. Hot tar burns: twenty-seven hospitalised cases . J Burn Care Rehabil15(4): 341—5.
66.
Seyb ST, Noordhoek L. et al. 1995. A study to determine the efficacy of treatment of hydrofluoric acid burns. J Burn Care Rebail16(3): 253—7.
67.
Smart JK1997. History of chemical and biological warfare: An American Perspective. Textbook of Military Medicine: Medicine Aspects of chemical and biological warfare. (http://www.usuhs.mil/cbw/history.htm )
68.
Steinman G.2005. Liposuction as a minimally invasive technique. Br J Anaest95(3): 355—7.
69.
Swanson, Biernan B et al. 1993. Airbags — lifesaving with toxic potential . Am J Emerg Med11: 38—9.
70.
Sykes RA1986. Chemical Burns: Retrospective review. J Burn Care Rehabil7(4): 343—7.
71.
Tambuscio A., Governa M. et al. 2006. Deep burn of the hands: early surgical management avoids the need for late revisions?Burns32(8): 1000—4. Epub Sep 1 2006.
72.
Terrill PJ, Gowar JP1990. Chromic acid burns: beware, be aggressive, be watchful . Br J Plast Surg43(6): 699—701.
73.
Tokuda Y., Kikuchi M., Takahashi O., Stein GH2005. Prehospital management of Sarin nerve gas terrorism in urban settings: 10 years after the Tokyo subway Sarin attack. Resuscitation68(2): 193—202. Epub 2005 Dec 1 Review.
74.
Trevino MA et al. 1983. Treatment of severe hydrofluoric acid exposure . J Occup Med25: 861—3.
75.
Vaglenova E.1997. Chemical Burns epidemiology. Annals of Burns and FireDisasters, Vol X: N1.
76.
Weinzweig J.1999. Plastic Surgery Secrets, 75: 389—395.
77.
Winemaker M., Douglas L., Peters W.1992. Combination alkali/thermal burns caused by ``black liquor'' in the pulp and paper industry. Burns18: 68—70.
78.
Yamauro K., Kao B.1997. Recurrent Ventricular Tachyarrythmias associated with QT prolongation following hydrofluoric burns. JClin Toxicol35(3): 311—3.
79.
Yano K., Hata Y., Matsuka O. et al. 1993. Experimental study on alkaline skin injuries — periodic changes in subcutaneous tissue pH and the effects exerted by washing . Burns4: 320—3.
