Abstract
This study examined the effects of maintaining cells in different media and the role of serum in glutamate and NMDA - induced neurotoxicity in rat cerebellar granule cells. Glutamate stimulated a concentration - dependent cell death with similar potency in cerebellar granule cells grown in BME and Neurobasal media without serum. However, the maximal cell death to glutamate and N- methyl-D-aspartate (NMDA) varied in the different media compositions. In the presence of serum, glutamate and NMDA - induced excitotoxicity was abolished, suggesting a factor(s) in serum which influences glutamate - receptor
Get full access to this article
View all access options for this article.
