1 The relative binding constants of four drugs to charcoal, silicone oil silicas and
acrylate copolymers was studied using an in-vitro
binding technique.
2 The maximum adsorption capacity (K2) was chosen as a measure of the degree of
binding and calculated by fitting to the Langmuir equation.
3 Charcoal alone was shown to be the most effective of the adsorbents chosen. The
possible use of silicone oils as an adsorbent delivery vehicle in treatment of
overdose is discussed.
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