Water-soluble chitosan and wood pulp fiber–based nonwovens were produced using wet-laying technology, and their properties were investigated for the potential application for severe hemorrhage. The pores of the wood pulp nonwovens were completely covered as the concentration of chitosan was increased. A phosphate buffer solution uptake of 997% was attained in the nonwoven loaded with chitosan concentration of 1.5 w/v%. The deposition of blood cells was found to increase with an increase in the water-soluble chitosan concentration. The blood-clotting time was found to be 170 s, making the developed nonwoven to promote blood-clotting mechanism by creating mechanical barrier to reduce the blood loss.
WuYWangFHuangY.Comparative evaluation of biological performance, biosecurity, and availability of cellulose-based absorbable hemostats. Clin Appl Thromb2018; 24: 566–574.
2.
HuZZhangDYLuST, et al. Chitosan-based composite materials for prospective hemostatic applications. Mar Drugs2018; 16: 273.
3.
PogorielovMVSikoraVZ.Chitosan as a hemostatic agent: current state. Eur J Med Ser B2015; 2: 24–33.
4.
KahyaN.Water soluble chitosan derivatives and their biological activities: a review abstract synthesis of water soluble chitosan derivatives. Polym Sci2018; 4: 1–11.
5.
XiaZWuSChenJ.Preparation of water soluble chitosan by hydrolysis using hydrogen peroxide. Int J Biol Macromol2013; 59: 242–245.
6.
DuYZhaoYDaiS, et al. Preparation of water-soluble chitosan from shrimp shell and its antibacterial activity. Innov Food Sci Emerg Technol2009; 10: 103–107.
7.
LiJDuYYangJ, et al. Preparation and characterisation of low molecular weight chitosan and chito-oligomers by a commercial enzyme. Polym Degrad Stab2005; 87: 441–448.
8.
LinHWangHXueC, et al. Preparation of chitosan oligomers by immobilized papain. Enzym Microb Technol2002; 31: 588–592.
9.
DuDXVuongBX.Study on preparation of water-soluble chitosan with varying molecular weights and its antioxidant activity. Adv Mat Sci Eng2019; 2019: 8781013.
10.
ShaoJYangYZhongQ.Studies on preparation of oligoglucosamine by oxidative degradation under microwave irradiation. Polym Degrad Stabil2003; 82: 395–398.
11.
WuQXLinDQYaoSJ.Design of chitosan and its water soluble derivatives-based drug carriers with polyelectrolyte complexes. Mar Drugs2014; 12: 6236–6253.
12.
HeJWangFWuY, et al. Preparation of the water-soluble chitosan-coated oxidized regenerated cellulose gauze. Cellulose2011; 18: 1651–1659.
13.
HeJMWuYDWangFW, et al. Hemostatic, antibacterial and degradable performance of the water-soluble chitosan-coated oxidized regenerated cellulose gauze. Fibers Polym2014; 15: 504–509.
14.
HubbeMAKoukoulasAA.Wet-laid nonwovens manufacture—chemical approaches using synthetic and cellulosic fibers. BioResources2016; 11: 5500–5552.
15.
DohSJLeeJYLimDY, et al. Manufacturing and analyses of wet-laid nonwoven consisting of carboxymethyl cellulose fibers. Fibers Polym2013; 14: 2176–2184.
16.
NohYKDuPKimIG, et al. Polymer mesh scaffold combined with cell-derived ECM for osteogenesis of human mesenchymal stem cells. Biomater Res2016; 20: 6.
17.
RampichováMKoštákováEFilováE, et al. Non-woven PGA/PVA fibrous mesh as an appropriate scaffold for chondrocyte proliferation. Physiol Res2010; 59(5): 773–781.
18.
ZhangYDengCQuB, et al. A study on wet and dry tensile properties of wood pulp/lyocell wetlace nonwovens. IOP Conf Ser Mater Sci Eng2017; 241: 12013.
19.
Giri DevVRHemamaliniT. Porous electrospun starch rich polycaprolactone blend nanofibers for severe hemorrhage. Int J Biol Macromol2018; 118: 1276–1283.
20.
RomainorANBChinSFPangSC, et al. Preparation and characterization of chitosan nanoparticles-doped cellulose films with antimicrobial property. J Nanomater2014; 2014: 710459.
21.
LiuCWangGSuiW, et al. Preparation and characterization of chitosan by a novel deacetylation approach using glycerol as green reaction solvent. ACS Sustain Chem Eng2017; 5: 4690–4698.
22.
CaiZKimJ.Characterization and electromechanical performance of cellulose-chitosan blend electro-active paper. Smart Mater Struct2008; 17: 035028.
23.
GuWLiHZhanH, et al. The interface interaction between water-soluble chitosan (DD = 50%) and peroxide bleached reed kraft pulp. J Appl Poly Sci2011; 121: 2606–2613.
