Abstract
The effects of 6-hydroxydopamine (6-OHDA, 8 μg) retrograde selective lesions of bilateral dopaminergic pathways, projecting from the ventral tegmental area of Tsai (VTA-A10) to the hippocampal formation (HF), were studied through assessment of male Sprague-Dawley rats behavior, before and following amphetamine challenge (day 15 and day 30, respectively after 6-OHDA injections). Significant differences in locomotor and exploratory activities and motor coordination were evidenced between and within groups by one-way analysis of variance (ANOVA). These VTA-hippocampal dopaminergic pathway lesions may provide a morphological basis for the interpretation of the psychomotor deficits shown in this study.
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