A study of peripheral blood mononuclear cell phenotyping and HIV testing was performed in 39 chronic hemodialysis patients. The following abnormalities were found in comparison to a control population: 1) a lower percentage of lymphocytes in the white blood cell differential count, 2) a lower percentage of total T cells, 3) a lower percentage and absolute number of suppressor T cells and 4) a lower percentage and absolute number of B cells. Both increasing age and blood transfusions were associated with reduced helper cells.
WilsonW.E.C., KirkpatrickC.H., TalmageD.W.Suppression of immunologic responsiveness in uremia. Ann Intern Med1965; 62: 1–14.
2.
KirkpatrickC.H., WilsonW.E.C., TalmageD.W.Immunologic studies in human organ transplantation. I. Observation and characterization of suppressed cutaneous reactivity in uremia. J Exp Med1964; 119: 727–42.
3.
DamminG.J., CouchN.P., MurrayJ.E.Prolonged survival of skin homografts in uremic patients. Ann NY Acad Sci1956-57; 64: 967–76.
4.
QuadracciL.J., RingdenO., KrzymanskiM.The effect of uremia and transplantation on lymphocyte subpopulations. Kidney Int1976; 10: 179–84.
5.
Boulton-JonesJ.M., VickR., CameronJ.S., BlackP.J.Immune responses in uremia. JAMA1970; 212: 1350–54.
6.
SiddiquiJ.Y., FitzA.E., LawtonR.L., KirkendallW.M.Causes of death in patients receiving long term hemodialysis. JAMA1970; 212: 1350–54.
7.
KlatzmannD., GluckmanJ.C., ChapuisF., FoucaultC.Suppression of lymphocyte reactivity by blood transfusion in uremic patients. Transplantation1984; 38: 222–30.
8.
LenhardV., MaassenG., Grosse-WildeH., WernetP., OpelzG.Effect of blood transfusions on immunoregulatory mononuclear cells in prospective transplant recipients. Transplant Proc1983; 15: 1011–5.
9.
KlatzmannD., GluckmanJ.C., FoucaultC., BensussanA., AssogbaU., DuboustA.Blood transfusions suppress lymphocyte reactivity in uremic patients: I. Proliferative responses. Transplantation1983; 35: 332–8.
10.
KlatzmannD., BensussanA., GluckmanJ.C., FoucaultC., DaussetJ., SasportesM.Blood transfusions suppress lymphocyte reactivity in uremic patients: II. Evidence for soluble suppressor factor. Transplantation1983; 36: 337–40.
11.
GuttmannR.D., McIntyreC., PoulsenR.S.Effect of blood transfusion on the development of cytotoxic antibody and immunoregulatory lymphocyte subsets enumerated by monoclonal antibodies and FACS analysis. Transplant Proc1982; 14: 344–6.