Abstract
A double blind trial on a selected group of 125 adult patients investigated the effect of atropine in premedication.
The addition of atropine to premedication of pethidine and promethazine made no statistical difference in the incidence of
(a) secretory problems, cough, laryngeal spasm, and vomiting during induction and recovery,
(b) arrhythmias during induction,
(c) bradycardia during operation.
References
1.
Burton J. D. K.
(1962 ): “Effects of Dry Anaesthetic Gases on Respiratory Mucous Membrane ”, Lancet 1 , 235 .
2.
Conway C. M.
, and
Payne J. P.
(1966 ): Acta Anaes. Scand. , Suppl. 23 , 538 .
3.
Eger E. I.
(1962 ): “Atropine Scopalamine and Related Compounds ”, Anesthesiology , 23 , 538 .
4.
Embley E. H.
(1902 ): “The Causation of Death during the Administration of Chloroform ”, Brit. Med. J. , 1 , 817 .
5.
Farman J. V.
(1967 ): “Circulatory Effects of Atropine during Halothane Anaesthesia ”, Brit. J. Anaesth. 39 , 226 .
6.
Goodman L. A.
, and
Gilman A.
(1970 ): The Pharmacological Basis of Therapeutics , 4th Edition, 640 , Macmillan , New York .
7.
Holt A. T.
(1962 ): “Premedication with Atropine Should Not be Routine ”, Lancet , 2 , 984 .
8.
Jones R. E.
,
Deutsch S.
, and
Turndorf H.
(1961 ): “Effects of Atropine on Cardiac Rhythm in Conscious and Anaesthetised Man ”, Anesthesiology , 22 , 67 .
9.
Levy M.
,
Porter V. P.
, and
Coakley C. C.
(1964 ): “Premedication Without Vagal Blocking Drugs ”, Anaes. and Anal. , 43 , 33 .
10.
Middleton M. J.
,
Zitzer J. M.
, and
Urbach K. F.
(1967 ): “Is Atropine Always Necessary Before General Anaesthesia? , Anaes. and Anal. , 46 , 51 .
11.
Pontinon P. J.
(1966 ): “The Importance of the Oculocardiac Reflex during Ocular Surgery ”, Acta Ophthal. , Suppl. 86 .
12.
Shearer W. M.
(1960 ): “The Evolution of Premedication ”, Brit. J. Anaesth. , 32 , 554 .
13.
Shearer W. M.
(1961 ): “The Evolution of Premedication ”, Brit. J. Anaes. , 33 , 219 .
14.
Tonkin P. J.
,
Conway C. M.
, and
Payne J. P.
(1964 ): “Hypoxemia Due to Atropine ”, Lancet , 1 , 14 .
